Fumonisin B1 is the most prevalent congener of the fumonisin mycotoxins produced by Fusarium verticilliodies and is considered by many to be the most toxic. Fumonisin B1 has been classified by IARC as a class 2B carcinogen. This is primarily due to evidence suggesting increased exposure to FB1 through contaminated foodstuffs is responsible for increased incidence of esophageal cancer in regions of China and South Africa. Fumonisin B1 exposure has also been implicated in the increased incidence of neural tube defects along the Texas/Mexico border. Therefore the principal goals of this research were to 1) Identify sorbent materials that would be compatible with the chemical characteristics of fumonisin B1 and evaluate their ability to sequester the toxin using established in vitro techniques; 2) evaluate urinary FB1 as a biomarker of exposure from a fumonisin contaminated diet; 3) utilize urinary FB1 as a diagnostic tool to evaluate the efficacy of NS in reducing biomarkers of FB1 bioavailability in a Ghanaian population suspected to be co-exposed to aflatoxins and fumonisins. Isothermal analysis and an alternative animal model were examined and compared to previously published results to determine the sorbent toxin interaction activity in vitro as a predictor of in vivo efficacy. An HPLC method for detection and quantitation of urinary FB1 was developed based on methods previously adapted for primary amine and biomarker analysis. Urinary FB1 was evaluated as an HPLC detectable biomarker using a rodent model. Calcium and sodium montmorillonite clays were selected to interact with the positive charge on FB1 at low pH and sorb the molecule. Ferrihydrite was selected to interact with the negative charge on the FB1 molecule at neutral to high pH. While both polarities of sorbent were effective, montmorillonite clays demonstrated a higher capacity for sorption of FB1 than ferrihydrite. These in vitro results were confirmed in a rodent model where urinary FB1 was reduced 27% in NovaSil treated rats vs. controls. Finally, in a Ghanaian population co-exposed to aflatoxins and fumonisins, urinary FB1 was significantly reduced at 2 time points when the NovaSil treatment was compared to placebo.

<p>The Volta Basin covers most of the major food producingdistricts of Ghana. Thus said, it is considered as the foodbasket of Ghana. This perception underscores the need toprotect the basins bio-physical environment and resource base.This concern has been mirrored by several initiatives both interms of policy and planning that aim at improving themanagement of the basin’s resource base to enable itspeople depend on it in meeting their livelihoods. Like mostcommunities that lie in the lower reaches of the Volta, thepeople of the South Tongu District have been brought under theimpact of the dam. Even though no extensive study has yet beenconducted to establish the extent of the dam’s impact inthe district, it is widely believed by the locals thatlivelihoods have been impacted by environmental changes. Keycomplaints include, amongst others, tree cover depletion,decline in soil fertility, poor agricultural productivity, lowrainfall and bush fires. At the district level some steps havebeen taken in the form of projects and programmes to addresspoverty and resource management issues, while others areunderway. This study seeks to contribute to the on-goinggeneral discussion concerning poverty and environmentalmanagement in the basin by presenting some perspectives fromfour villages, namely, Torsukpo, Agbogbla, Akato and Alesikpein the South Tongu District. From two perspectives, thesecommunities are considered as homogenous: (i) they are allpredominantly<i>ewes</i>with respect to ethnic composition, and (ii)subsistence farming features as a key occupation in all thecommunities. Among the range of issues identified in thedistrict, the study discusses mainly conservation (with respectto tree planting), bush fires and co-operative management. Ittreats these issues with focuses on key socio-cultural factors.In the examination of these issues institutional matters suchas tenure are seen as central players in resource managementand are thus given attention. While information gathered hereincontributes generally to deepening knowledge on the prevailingproblems, some recommendations are also offered as possiblesteps to improving resource management and livelihoods in theDistrict.</p><p><b>Key words:</b>environment; natural resources; lower volta;local people; livelihood</p>

Texte remanié de: Dissertation Ph. D.. Titre de soutenance : A history of development in the Northern territories of the Gold Coast, 1899-1957. / Bibliogr. p. 243-254.

Thesis (Ph. D.)--University of Alberta, 2010. / Title from pdf file main screen (viewed on January 12, 2010). "A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Political Science, University of Alberta." "Spring 2010." Includes bibliographical references.

Thesis (Ph. D.)--University of Alberta, 2010. / Title from pdf file main screen (viewed on January 12, 2010). "A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Political Science, University of Alberta." "Spring 2010." Includes bibliographical references.

Thesis--Freiburg i. B. / Includes bibliographical references (p. 262-272).

A revision of the author's Thesis (Ph. D.)--Cambridge University, 1970. / Reprint. Originally published: Marriage among the matrilineal elite. London ; New York : Cambridge University Press, 1974.(Cambridge studies in social anthropology ; no. 8). Includes bibliographical references (p. 166-177) and index.

Thesis--Göteborg. / Extra t.p. with thesis statement inserted. Includes bibliographical references (p. i-iii).

The Domestic Violence Act was passed in Ghana in 2007 marking a shift in the legal recourse available to survivors of intimate partner violence. The goal of my research is to identify the social, cultural, and legal changes that have occurred in Accra, Ghana and the surrounding areas since the passage of the DV Act. While in Ghana I spoke with men and women who were involved in the struggle to get the bill passed, as well as NGO employees and government officials who have seen men and women utilize the legal rights that the bill provides. I wanted to learn as much as I could about the cultural complexities of Ghana that continue to make the eradication of intimate partner violence so difficult. In the end, I hope that my research will add to a growing understanding of what is most lacking in the fight to attenuate the deleterious effects of intimate partner violence, so that advocates will be better able to truly implement the DVA’s emancipatory qualities. I also hope that the study will be a catalyst to promote continued education and invigorate activism. Methodologically, I used qualitative research tenets, utilizing in depth interviews and emergent coding. Results show how socio-culturally informed gendered attitudes and norms heavily impact the implementation of and enforcement of legal frameworks within communities. Findings also aid in a better understanding of the factors that surround violence against women in Ghana, and help explain how such factors are interrelated and mutually reinforcing. / text

The performance and operation of privatisation in the water sector in developing countries typically diverges from that proposed within the rationalising theoretical framework. There is a broad literature that considers the various aspects of such performance and operation, from the nature of outcomes typically characterised by dispute and renegotiation, to the implications for consumers. It is the purpose of this thesis to analyse the underlying factors that contribute to this typical dispute and renegotiation process, utilising the theoretical rationale for the programme, and its associated weakness and assumptions, as an explanatory framework. Through this analysis it is possible to expose and identify the particular aspects of private sector participation (PSP), the contracts established and administration thereof, which contribute to such problematic implementation. The utilisation of such a framework further permits the identification of likely implications for the functioning of PSP where implemented prospectively. The examination of these connections is performed in a case study environment, with privatisation of water services in Ghana providing the context. The Ghanaian experience shows significant deficiencies in contract design that entail considerable delays and disputes between parties, with contractual deficiencies intensifying the already inevitable role of institutional intervention. Conceptions of water as a merit good and human right, problematic commercial viability, and an incoherent implementation with local contextual variation all further contribute to the contradictory environment of the water sector in Ghana. Theoretical weaknesses, inconsistencies and problematic assumptions are manifest in the sector and contribute to divergence in performance, and where ideological commitment to the programme is evident, this divergence is exaggerated. Theoretical validity for sector policy is therefore questionable, with consequences of increased distortion in risk transfer, significant concessions to the private sector, and the increased role of institutions. This process, it is proposed, threatens the functioning of the programme where implemented, with regulation undermined, inherent and acknowledged renegotiation and dispute, paralleled by a failure to provide sufficient capacity and structure to sector institutions.