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Characterization of the Glucocorticoid Receptor in a Rat Model of Low Back PainIbrahim, Shaimaa 14 October 2019 (has links)
No description available.
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The Effects of Neuroendocrine Stress on Larval DevelopmentKirschman, Lucas James 01 August 2017 (has links) (PDF)
Environmental stressors are ubiquitous. Animals will face a variety of natural and anthropogenic stressors throughout their life cycle. The physiological mechanisms that mediate stressful stimuli can have pleiotropic effects on life history traits, such as reproduction and development. Furthermore, these phenotypic changes can affect larger-scale ecosystem dynamics, like nutrient cycling and disease epizootics. Animals are not equally susceptible to stressors across all stages of their life cycles. Critical windows of development, common in young and developing animals, are time periods when stressors have an outsized effect and can permanently alter phenotype. Larval amphibians use a critical window in late larval development wherein activation of the hypothalamic-pituitary-adrenal/interrenal (HPA/I) axis speeds their development, allowing them to metamorphose and escape suboptimal aquatic habitat. Accelerated development comes at a cost, the glucocorticoid (GC) hormones secreted by the HPA/I axis affect other systems such as growth, immune function, metabolism, and nutrient use. In chapter two, I investigated the effects of GC hormones on metabolism, energetics, and nutrient oxidation in larval wood frogs. The results show that GC hormones increase metabolism, reduce lipid stores, and increase protein oxidation during metamorphic climax. Chapter three focuses on the effects of GC hormones on immune function and r susceptibility. I found that chronic exposure to GC hormones increased ranavirus replication in infected wood frog larvae, but did not affect survival time. This could contribute to ranavirus epizootics. Acute GC hormone exposure increased survival, possibly by activing the inflammatory response. Finally, chapter four investigates the effects of GC hormones on nutrient stoichiometry. I found that larvae treated with GC hormones had lower nitrogen to phosphorus ratios, possibly because disrupted skeletal ossification. They also had reduced phosphorus excretion, which could affect ecosystem-level processes like nutrient cycling and decomposition.
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The role of hippocampal glucocorticoid receptors in status epilepticusKraus, Kimberly 23 August 2022 (has links)
No description available.
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The Dose Dependent Response of Dexamethasone on the Genotype and Phenotype of Trabecular Meshwork CellsMount, Zachary 22 August 2022 (has links)
No description available.
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Role of Glucocorticoid Receptor and Mineralocorticoid Receptor in Controlling Amphibian MetamorphosisSterner, Zachary 23 May 2022 (has links)
No description available.
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Modulation of Folate Receptor-alpha by Glucocorticoid Receptor and Progesterone ReceptorTran, Thuyet Van 03 January 2005 (has links)
No description available.
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Differential Regulation of Glucocorticoid and Progesterone Receptor Subcellular Localization by Tetratricopeptide Repeat Domain ProteinsBanerjee, Ananya 07 May 2007 (has links)
No description available.
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Role of FKBP51 and FKBP52 in Glucocorticoid Receptor Regulated MetabolismWarrier, Manya 12 November 2008 (has links)
No description available.
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Glucocorticoid-Induced Apoptosis: The Role of Reactive Oxygen Species and the ProteasomePickle, Sarah Rachel 25 April 2005 (has links)
No description available.
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Role of the Prefrontal Glucocorticoid Receptor in Synaptic, Neuroendocrine, and Behavioral Stress AdaptationMcKlveen, Jessica M. 05 June 2015 (has links)
No description available.
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