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We investigated the relationship between glucose tolerance and birth weight in a group of 7-year-old black South Africans on whom longitudinal anthropometric data were available. Oral glucose tolerance tests (OGTT’s) were carried out on 152 subjects and inverse correlations were found between birth weight and the total amount of insulin secreted during the first 30 minutes (r= -0.19, p=0.04) and the last 90 minutes (r= -0.19, p=0.04) of the oral glucose tolerance test and also between birth weight and the 30 minute glucose concentrations (r= -0.20, p=0.02). Children born with low birth weights but who had high weights at 7 years, had higher insulin concentrations and indices of obesity compared with those with low birth weights and low weights at 7 years of age. There were also positive correlations between weight velocity and BMI (r=0.24, p=0.02) and weight velocity and postprandial insulin levels (r=0.31, p=0.001). Thus low birth weight in conjunction with rapid childhood gains in weight especially as subcutaneous fat, produces poor glucose tolerance in 7-year-old children and may make them susceptible to the development of Type II diabetes later in life.

This study determined the effects of gestational obesity on the long-term metabolic status of the mother and if obesity management during or after pregnancy could attenuate these effects. At 120 days prior to estrus, 8 ewes received 100 percent of NRC nutrient requirements (control group) and 24 ewes had free access to feed (obesity induction). Beginning on day 42 of gestation, 8 obese ewes were restricted to 65 percent of NRC nutrient requirements. Following parturition, controls and all but one group of obese ewes were fed 100 percent of NRC nutrient requirements. At postpartum days (PPD) 1 and 150, glucose tolerance tests were administered to ewes. At both PPD1 and PPD150, obesity resulted in insulin resistance, impairment of whole-body glucose utilization, increased levels of circulating leptin, and altered profiles of amino acids in plasma; however, these effects were diminished in ewes receiving obesity management during or after gestation. Additionally at PPD150, obesity increased the circulating levels of ammonia and urea in ewes, which was prevented by realimentation to 100 percent NRC requirements. These results indicate that weight reduction in obese dams during pregnancy or after parturition can beneficially ameliorate the adverse effects of gestational obesity on the mother.

Diss. (sammanfattning) Stockholm : Karol. inst. / Titel på diss.-titelbl.: Islet glucose metabolism and insulin secretion in two animal models of glucose intolerance. Härtill 5 uppsatser.

Thesis (M.S.)--University of Toledo, 2007. / "In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 59-68.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 5 uppsatser.

Thesis (Ph.D.)--Indiana University, 2009. / Title from screen (viewed on December 9, 2009). Department of Biochemistry and Molecular Biology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Jeffrey S. Elmendorf, Peter J. Roach, Joseph T. Brozinick, Michael S. Sturek, Robert V. Considine. Includes vitae. Includes bibliographical references (leaves 97-124).

Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 5 uppsatser.

Diss. (sammanfattning) Uppsala : Univ., 2003. / Härtill 4 uppsatser.