Thesis (Ph. D.)--Ohio University, June, 1987. / Title from PDF t.p.

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 6 uppsatser.

Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1998? / Bibliography: leaves 206-254.

Thesis (Ph. D.)--Lehigh University, 1999. / Includes vita. Includes bibliographical references.

Thesis (Ph. D.)--Virginia Polytechnic Institute and State University, 1990. / Vita. Abstract. Includes bibliographical references (leaves 354-365). Also available via the Internet

Thesis (Ph. D.)--University of Wisconsin--Madison, 1984. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 142-154).

No description available.

The populations of cells which infiltrate tissue allografts in W mutant mice and their non-mutant littermates were investigated using the light and electron microscopes. Initially, thyroid allografts were attempted but this tissue proved unsatisfactory for comparative studies and skin was used instead. The cells infiltrating the skin grafts were isolated enzymatically and characterized using the light microscope. In addition, cells in epon sections of skin grafts were identified using the electron miscroscope. The frequency of the various cell types isolated from grafts in mutant mice differed significantly from that of cells isolated from grafts in non-mutant mice. The electron microscope studies indicated that the cell types infiltrating skin allografts are the same in both mutant and non-mutant hosts. / Science, Faculty of / Zoology, Department of / Graduate

Hematopoietic stem cell transplant was developed as a curative therapy to treat onco-hematological diseases and recently indications for this therapy have expanded to include solid tumors, hemoglobinopathies and other genetic diseases and disorders. Two major types of hematopoietic stem cell transplant have been developed. Autologous transplants aim to deliver a massive dose of radiation and/or chemotherapy that is capable of ablating the hematopoietic stem cells in the bone marrow. The patient is then "rescued" from this lethal dose of treatment by an infusion of their own hematopoietic stem cells. Allogeneic transplants are designed to either functionally replace a cell class, or an enzyme or biological function absent in the patient, or to consolidate a remission in a onco-hematological disease via the graft-versus-tumor effect . Two of the largest causes of non-relapse mortality from an allogeneic hematopoietic stem cell transplant are acute and chronic graft-versus-host disease, in which immune cells derived from the graft recognize normal host tissue as foreign and attack these tissues. A host of biomarkers for acute graft versus host disease have been identified, but there is almost none for chronic graft versus host disease. Herein, a methodology to discover and validate a biomarker(s) for the most common organ system affected by chronic graft versus host disease is proposed.

No description available.