Global ETD Search

31	The Roles of the Phosphatases of Regenerating Liver (PRLs) in Oncology and Normal Physiology Frederick Georges Bernard Nguele Meke (16671573) 03 August 2023 (has links) <p> </p> <p>The phosphatases of regenerating liver are a subfamily of protein tyrosine phosphatases that consist of PRL1, PRL2 and PRL3. The overexpression of PRLs promote cell proliferation, migration and invasion and contribute to tumorigenesis and metastasis to aggravate survival outcome. Although there is increasing interest in understanding the implication of these phosphatases in tumor development, currently, limited knowledge is available about their mechanism of action and the efficacy of PRL inhibition in <em>in vivo</em> tumor models, the tumor extrinsic role of PRLs that allow them to impact tumor development, as well as <em>in vivo</em> physiological function of PRLs that could implicate them in diseases other than cancer. The work presented here aims to address these limitations.</p> <p><br></p> Signal transduction Tumour immunology Haematological tumours Solid tumours Phosphatase of regenerating liver Tp53 PTEN tumor microenviroment (TME) tumor immunogenic microenvironment tumor vasculature formation T cell activation Dendritic cell Obesity mitochondrial function-related genes Tp53 deficiency mouse models syngeneic MC38 mouse model