Spelling suggestions: "subject:"haematopoiesis"" "subject:"haemopoietic""
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Regulation of the c myb gene by interleukin 2Lauder, Angus James January 2001 (has links)
No description available.
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Transcriptional regulation and function of the stem cell leukemia geneMurrell, Adele Meinie January 1994 (has links)
No description available.
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Studies on an eosinophil differentiation factor produced by a T-hybrid lineWarren, David John January 1985 (has links)
No description available.
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Analysis of factor-independent mutants induced by retroviral insertional mutagenesisFranz, Marie-Josee January 1994 (has links)
No description available.
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Inducible repression of MYB function in T cellsTaylor, Deborah Lisa January 1997 (has links)
No description available.
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Functional characterisation of bone marrow stromal cells and their responses to leukaemia therapyKovacs, Ian E. L. January 2000 (has links)
No description available.
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The c-Kit signalling pathway and acute non-lymphoblastic leukaemogenesisInman, Louise January 2001 (has links)
No description available.
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Expression of the HOXA gene cluster in human myeloid cell developmentKirkbride, Helen J. January 1997 (has links)
No description available.
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Molecular analysis of putative haemopoietic gene products derived from murine embryonal stem cellsBaird, Janet W. January 2001 (has links)
No description available.
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Phenotypic and functional changes in cord blood stem cell progeny after cytokine activationRamirez, Carole , Women's & Children's Health, Faculty of Medicine, UNSW January 2007 (has links)
Human umbilical cord blood, an alternate source of haematopoietic stem cells (HSC), has been successfully used to reconstitute haematopoiesis in both related and unrelated transplant recipients. However, because CB has fewer total cells (and as a consequence fewer HSC and progenitor cells) CB transplant recipients often experience delayed engraftment as compared with that seen in bone marrow or mobilized peripheral blood transplant recipients. Delayed engraftment exposes patients to an increased risk of infection and bleeding. Cytokine-mediated expansion has been investigated to improve engraftment after CB HSC transplantation as a means to expand the total cell number and both the HSC and progenitors populations. However, its effect on HSC function remains controversial. We hypothesise that if cytokine-mediated expansion promotes divisional recruitment and multilineage differentiation it causes changes in phenotype and cell cycle related gene expression which may be detrimental to the engraftment capacity of haematopoietic cells. Therefore we investigated the relationship between cell division, phenotype and engraftment potential of CB CD34+ cells following cytokine-mediated expansion. High resolution cell division tracking using the fluorescent dye CFSE was used to monitor changes as a consequence of cytokine-mediated expansion in phenotype and function in CB CD34+ cells. Cytokine-mediated expansion caused upregulation of lineage and proliferation markers and adhesion molecules and downregulation of putative stem cell markers with concomitant cell division. However, these changes in phenotype as a consequence of cytokine-mediated expansion may not reflect or be predictive of a functional change in the expanded population. Cytokine-mediated expansion of CB CD34+ also caused changes in cell cycle related gene expression of G1 phase regulators. CB CD34+ cells exhibited expression of all D cyclins, albeit at different levels and p21WAF1 was differentially expressed across CB samples. The effect of cell division on the engraftment potential as a consequence of cytokine-mediated expansion was examined in CB CD34+. Cytokine-mediated expansion of CB CD34+ cells reduced, but did not completely eliminate engraftment potential, as a proportion of the expanded and divided cell populations retained their ability to engraft the NOD-SCID mouse. Overall, this study confirms reports in the literature that cytokine-mediated expansion induces changes in the phenotype of HSC and compromises their in vivo function.
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