The high incidence of long bone fractures and appreciable rate of delayed and non-union (5-10%) necessitates the development of non-invasive tools to monitor healing progression. The objective of this study was to develop a novel µCT-based measure of three-dimensional bone connectivity and to compare its ability to assess fracture callus mechanical stability to previously described measures. Bone connectivity parameters local to the failure surface were found to significantly correlate with mechanical stability, and proved superior to previously developed measures of torsional rigidity. Visualization of the failure surfaces demonstrated a consistent failure pattern indicative of the applied torsional loading, however the locations of the failure surfaces showed varying levels of fracture callus involvement. The results of this proof of concept work indicate the potential utility of bone connectivity analysis in non-invasive assessment of fracture callus stability.

Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (p. 271-291).

Abstract of Thesis (Ph. D.)--Ohio state University, 1925. / Autobiography. Autographed from type-written copy.

Thesis (M.A.)--Wheaton College Graduate School, 2001. / Abstract. Includes bibliographical references (leaves 128-143).

In this thesis I define theatrical healing as using theater to practice healing. I focus on the creative impulse for and process of two plays: Scavenger Heart and The Chronicles of Bad Ass Women. In order to define these texts within the framework of theatrical healing I start at the beginning, when and why I first came to theater, and move from there to the development and productions of these two experiments. I explain how the design of these plays was driven by a conscious, and sometimes unconscious, ambition to heal very specific afflictions. I hope this delineation places Scavenger Heart and Chronicles on two points along a trajectory of my practice in theatrical healing. / text

One of the characteristic features in Matthew’s Gospel is his emphasis of the title ‘Son of David’ in Jesus’ healings. However, there is sparse reference to the expectation of a ‘healing messiah’ in Jewish literature. Recent study has attempted to understand this issue within Jewish traditions by focusing on the shepherding motif in Ezekiel 34 (Matt 9:36; 10:6; 15:24). While this result seems convincing for some scholars, another issue may arise relating to Jesus’ healing ministry: Why does Matthew quote explicitly (Matt 8:17; 12:18-21) from Isaiah (Isa 53:4; 42:1-4), but only alludes to Ezekiel 34? This thesis will seek to demonstrate that the phenomenon of ‘healing messiah’ is a product of Matthew’s reflection upon early Jewish traditions rooted in the Old Testament as well as upon the received Christian traditions, and that the varying aspects of the depiction of Jesus in healings suggested in recent studies are, to some extent, dependent upon their methodological approaches. Through the employment of appropriate methods, a more comprehensive picture of Jesus as the healer will emerge in this thesis. The Matthean presentation of the ‘healing Son of David’ is traced to Jewish messianic expectations, which understand the establishment of justice as a function of a Davidic kingship (Isa 11:4-5; Jer 35:5; Ezek 34:16; Ps 72:1-3; cf. Pss. Sol. 17). For Matthew, the Davidic theme provides a framework to elaborate healing aspects of Jesus (as ‘servant’ and ‘shepherd’) and to emphasize the nature of his kingship, in which healings belong to a category of care for the marginalized. This depiction of Jesus contributes to the understanding of christology of Matthew’s Gospel, and also serves as a critique towards the traditional Jewish expectation of a militant Davidic messiah (cf. Pss. Sol. 17-18) as well as towards the Roman imperial rule.

Activities aimed at treating and/or monitoring the healing of wounds consume many nursing hours. However, most of the treatments used by nurses in caring for wounds are best classified as "reports of techniques" and are not based on research. Though no single initiator or promoter of wound healing has been isolated, epidermal growth factor (EGF), a naturally occurring polypeptide, has been reported to promote epidermal growth in vitro. In vivo, the application of EGF has been reported to increase proliferation and differentiation of epidermal tissue in newborn mice and to enhance the healing of corneal wounds in rabbits. Originally found in the submaxillary gland of male mice, EGF has now been found in the urine of humans. No reports have documented the in vivo effects of application of EGF to epidermal wounds of animals to determine if it will promote wound healing. The purposes of this study were to further elucidate the physiological and perhaps therapeutic function of EGF and to evaluate the feasibility in terms of availability, cost, and manageability of the pig as an animal model for controlled investigation of clinical nursing problems. Wound healing is a composite phenomenon of distinct yet interrelated phases: epithelialization, contraction, and fibrous healing. The reepithelialization of the wound is the result of migration of epidermal cells adjacent to the wound edge and differentiation of the new cells. Because of the risks and ethics involved in repeated biopsy of human wounds and the prematurity of use of EGF in humans, the specific problem this study was designed to answer is: Does the topical application of mouse epidermal growth factor (mEGF) increase the rate of healing of epidermal wounds in the domestic pig? An experimental design was used to test four hypotheses. Three of the hypotheses related to the process of wound healing were: (1) Topical application of 40 ng of mEGF will increase migration of keratinocytes over the wound. (2) Topical application of 40 ng of mEGF will increase the mitotic index. (3) Topical application of 40 ng of mEGF will increase the differentiation of keratinocytes over the wound. A fourth hypothesis, topical application of 40 ng of mEGF will increase the protein/DNA ratio in keratinocytes adjacent to and covering the wound, was tested since EGF is reported to be a potent mitogen increasing DNA synthesis and increasing intracellular protein. Using a modification of the Winter method, 82 wounds were created on the backs of ten young Yorkshire mix pigs in order to simulate the healing of two wounds over time. Mouse EGF was applied every two hours for six hours then every six hours for 48 hours (total of 54 hours) and 0.9 percent sodium chloride was applied to the control wounds in identical fashion. Tissue obtained from randomly assigned timed biopsises were examined histologically for the migration, mitosis, and differentiation of the keratinocytes. In addition, a portion of each biopsy was utilized for determination of protein/DNA ratio. Dependent t-tests of means showed no statistically significant differences between mEGF treated experimental and control wounds. Therefore, none of the hypotheses were supported. Graphic presentation of the data does indicate differences at specific points especially in the first 18-48 hours post-wounding. The pig was found to be a satisfactory model for controlled studies since the epidermal tissue is similar and the animals are relatively inexpensive, readily available, and become domesticated or relatively easy to handle in a short period of time.

Multiple traumas, including sexual vulnerabilities, sexual abuse, and sexualized violence, remain substantially higher among Indigenous peoples in Canada than among non-Indigenous peoples. These trends are rooted in a colonial history that includes systemic racism, a deprivation of lands and culture and other intergenerational traumas. Mental health sequelae following sexual vulnerabilities such as abuse and violence may include mood disorders, low self-worth, posttraumatic stress and a range of issues related to anxiety—yet Western mental health services are typically under-used by Indigenous peoples managing these issues. Indigenous mental health and healing services are explored as a more culturally appropriate and successful alternative for Indigenous clients experiencing multiple traumas.

Multiple traumas, including sexual vulnerabilities, sexual abuse, and sexualized violence, remain substantially higher among Indigenous peoples in Canada than among non-Indigenous peoples. These trends are rooted in a colonial history that includes systemic racism, a deprivation of lands and culture and other intergenerational traumas. Mental health sequelae following sexual vulnerabilities such as abuse and violence may include mood disorders, low self-worth, posttraumatic stress and a range of issues related to anxiety—yet Western mental health services are typically under-used by Indigenous peoples managing these issues. Indigenous mental health and healing services are explored as a more culturally appropriate and successful alternative for Indigenous clients experiencing multiple traumas.

This thesis demonstrates the effect of micro-damage healing on stress and displacement fields in the vicinity of a crack tip in the material that tend to self-heal. The micro-damage healing model is modeled by incorporating time-dependent traction within the crack faces. This time-dependent traction occurs in a small zone referred to as healing process zone. The effect of the micro-damage healing on crack propagation in elastic media is investigated by deriving analytical relations for Stress Intensity Factor (SIF) when micro-damage healing mechanism is in effect. It is shown that the larger values of both healing process zone and bonding strength decrease the value of SIF near the crack tip. In order to clearly capture this phenomenon, a novel technique based on complex variables is used to derive the equations to calculate the stress and displacement fields in elastic media. Using the third correspondence principle, which is suitable in analyzing the crack shortening (healing phenomenon), the corresponding results of stress and displacement fields in elastic media are converted into viscoelastic media. Since asphalt has time-dependent material properties, the viscoelastic result is more accurate than the elastic. It is shown that an increase in the value of both healing process zone and bonding strength results in a decrease in the stress and displacement fields near the crack tip. Finally, the effect of using different coefficients in defining the bonding strength and relaxation time is evaluated. Asphalt concrete pavements are concurrently subjected to mechanical and environmental loading conditions during their service life. Applied mechanical and environmental loadings gradually degrade properties of asphalt concrete pavements. However, under specific conditions, asphalt concrete has the potential to heal and regain part of its strength. Identifying a model for the healing process is crucial. This proposed model is not dependent on the test methods that empower its usage in computational modeling. Moreover, this research considers both effects of instantaneous healing (a result of wetting) and time-dependent bond strength (a result of molecular diffusion between the crack faces), using the complex-variable method. Schapery (1989) considered only instantaneous healing and regarded it as the total bond strength. Therefore, considering both effects of instantaneous and time-dependent bond-strength makes this model superior with respect to the analogous model. It is hoped that this research provides insight on the healing mechanism at micro-scale.