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Humans are exposed to chemicals every day in our indoor environment. Chemicals have contributed to increased prosperity but also caused negative health effects. Children are vulnerable to chemicals because of their development and they breathe and drink more in relation to their body weight. That is why it’s important to reduce chemical exposure in environment for children. Preschools have a central role when it comes to materials and products that may pose a risk for exposure. The municipality has an important role to achieve a nontoxic environment which is based on a Swedish environmental quality goal (Non-toxic environment). This study is a part of the prioritized local environmental work in the municipal of Nordmaling. An inventory has been done to find out what type of chemicals that may expose children to harmful effects in preschools of Nordmaling. Electronic as a toy, soft and smelling toys, plastic around food and drinks, foam play pads were common products found during the inventory. This materials containing phthalates, brominated flame retardants, perfluorinated compounds, bisphenol A, lead and cadmium that can expose children through leaching into the indoor environment. A guidance have been constructed to achieve a non-toxic environment based on the results from the inventory in a cost effective way. The conclusion of the report is clear, identified problem areas can quickly be accomplished with small measures and low costs. Increased awareness of harmful substances and good routines for purchases and cleaning can further reduce the exposure to chemicals in the preschools.

Ahvaz, Iran ranks as the most polluted city of the world in terms of PM10 concentrations that lead to deleterious effects on its inhabitants. This study examines diurnal, weekly, monthly and annual fluctuations of PM10 between 2009 and 2014 in Ahvaz. Health effects of PM10 levels are also assessed using the World Health Organization AirQ software. Over the study period, the mean PM10 level in Ahvaz was 249.5 mu g m(-3), with maximum and minimum values in July (420.5 mu g m(-3)) and January (154.6 mu g m(-3)), respectively. The cumulative diurnal PM10 profile exhibits a dominant peak between 08:00-11:00 (local time) with the lowest levels in the afternoon hours. While weekend PM10 levels are not significantly reduced as compared to weekdays, an anthropogenic signature is instead observed diurnally on weekdays, which exhibit higher PM10 levels between 07:00-17:00 by an average amount of 14.2 mu g m(-3) as compared to weekend days. PMio has shown a steady mean-annual decline between 2009 (315.2 mu g m(-3)) and 2014 (143.5 mu g m(-3)). The AirQ model predicts that mortality was a health outcome for a total of 3777 individuals between 2009 and 2014 (i.e., 630 per year). The results of this study motivate more aggressive strategies in Ahvaz and similarly polluted desert cities to reduce the health effects of the enormous ambient aerosol concentrations. (C) 2016 Elsevier B.V. All rights reserved.

Parabens have been used as antimicrobial preservatives in multiple different types of products for decades, however relatively recent studies have caused concern as to whether their wide-use could be potentially harmful. The following paper reviews the extensive areas of human exposure, from mother to fetus, infants via breast milk, baby and child care products through adult personal care products, and other environmental sources. The potential impacts on human health are also discussed. Parabens predominantly impact biological systems as an endocrine disruptor not only by binding to the human Estrogen Receptor directly, but increasing the availability of naturally occurring 17β-estradiol, further potentiating the effect. Alternative antimicrobial preservatives are also discussed, along with their efficacies and potential health concerns. Common alternatives found in personal care products include phenoxyethanol, methylisothiazolinone, and formaldehyde releasers. Additionally, weak organic acids and plant-derived essential oils are also used in personal care products, but tend to be added more so to food products to prevent the growth of spoilage bacteria, fungi and mold. The potential for these alternatives to replace the use of parabens in personal care products, our greatest area of exposure, is very promising. If parabens in personal care products were replaced with a safe and effective alternative, then the other areas of environmental exposure would likely be negligible to produce any harm on society. Future investigation into the nuances of the various plant-derived essential oils and effective formulations for preservation, is likely the most promising solution, due to their mostly harmless nature. Lastly, the discussion of proposed future research in order to lead to a more definitive connection between paraben exposure and adverse health effects is presented.

Fine particulate matter (PM2.5) has been associated with adverse effects on human health, but whether specific components of PM2.5 are responsible for specific health effects is still under investigation. The complex chemical composition of PM2.5 and issues such as multi-component interactions, spatial variability and sampling/instrument error further complicates this analysis. A complementary approach to examining species-specific associations is to assess associations between health outcomes and sources contributing to PM2.5, which can provide critical information to regulators to tighten controls on sources that contribute most to adverse health effects and allows for better multi-pollutant epidemiologic analyses, as the number of source-categories is typically far less than the number of PM2.5 species. This study develops and evaluates various air quality modeling approaches for determining daily source contributions to ambient PM2.5. Results from long-term air quality simulations using an emissions-based model (Models-3/CMAQ - Community Multiscale Air-Quality model) were evaluated in terms of the model's ability to simulate short-term (e.g., daily) variability in concentrations of PM2.5 components. To examine source-specific health outcomes, an extended PM2.5 source-apportionment model, CMB-LGO (Chemical Mass Balance incorporating the Lipschitz Global Optimizer) was developed and compared with results based on other approaches such as CMB, PMF (Positive Matrix Factorization), and Models-3/CMAQ in terms of simulating the daily variability of source impacts. Based on findings from spatial and temporal analyses of tracer concentrations and source impacts, PM2.5 source-apportionment results from CMB-LGO and PMF were applied in a health-study for the Atlanta area. Despite methodological differences and uncertainties in the apportionment process, good agreement was observed between the CMB-LGO and PMF based risk ratios, indicating to the usefulness of applying apportionment methods in health studies.

Iceland is the land-based expression of the Mid-Atlantic Ridge and is one of the most volcanically active regions of the world. Volcanic eruptions on Iceland are a source of geological hazard to humans and the environment due to the release of ash, gases and lava. The composition of the material released is determined by the chemical composition of the surrounding bedrock and the magma upwelling from the Earth’s crust. The effects of historical eruptions on Iceland have been locally devastating and of global impact. The eruption of Lakagígar in 1783-1784 is known to have been the largest eruption in historical time, and is responsible for the death of ~22 % of theIcelandic population. Skeletal fluorosis is a disease that is sometimes observed following large volcanic eruptions. Volcanic ash can travel great distances in the upper atmosphere and spread over vast areas far away from the erupting volcano. Volcanic ash can change incomposition in the atmosphere, and bring about climate-changing effects. Most notably in recent times, violent ash eruptions can also cause problems to the aviation industry, when ash enters and damages airplane engines. Iceland has many active volcanoes and needs to ensure plans for future eruptions are in place. One such measure is an evacuation plan that protects people living close to an active volcano, such as the most lively on Iceland: Hekla, Katla and Eyjafjallajökull.

Many of the factors that shape contaminant accumulation profiles in marine mammals also strongly influence fat soluble vitamin accumulation. Vitamin A and E are essential fat soluble nutrients for numerous biological processes, including reproduction, growth, endocrine and immune function. Contaminants, such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), can alter vitamin dynamics; as such these vitamins have been proposed as sensitive biomarkers of contaminant exposure in wildlife. In light of these considerations, the present thesis was aimed at better understanding the factors that influence the accumulation of lipophilic contaminants and vitamins in western Arctic beluga whales, and to determine if there was an interaction between the two. Maternal offloading to neonates during gestation reduced overall contaminant (PCBs and PBDEs) and vitamin (A and E) concentrations in reproductively active female whales. The PCB and PBDE congener pattern in mothers changed during gestation as a result of preferential transfer of light-low Log KOW congeners to the fetus. Overall, female beluga whales transferred approximately 11% of their PCB and PBDE blubber burden to their fetus. In terms of vitamins transfer, lower concentrations of tocopherols, retinol and retinyl esters were found in reproductively active females relative to males and reproductively inactive females. Metabolism was also found to be an important factor for contaminant and vitamin accumulation in beluga tissues. In a principal components analysis, PCBs clustered into metabolically-derived structure-activity groups, which separated along the first principal component according to its metabolic potential (metabolizable vs. recalcitrant). Contaminant-related up-regulation of metabolizing enzymes, including cytochrome P450, likely explained changes in the concentration and pattern of PCB and PBDE congeners, as well as hepatic, plasma, and blubber vitamin A and E. Since vitamins and lipophilic contaminants accumulated in beluga whales in the same way in relation to most biological processes, including sex, reproduction, size, condition, and feeding ecology, it was important to control and reduce the number of these confounding factors before claiming any tissue vitamin change was indeed the result of chemical exposure. In doing so, it was found that vitamin A and E homeostasis was influenced by PCBs in beluga whales, resulting in reduced hepatic storage and increased plasma and blubber concentrations. Overall, these results suggest that liver, plasma, and inner blubber vitamin A and E concentrations can be sensitive biomarkers of contaminant exposure only if major confounding effects are taken into consideration. The implications of altered vitamin dynamics on the health of beluga whales is unknown at this time; however, as Arctic marine mammals face continued stress related to climate change, increased human disturbance and emergence of infectious diseases, this study can serve as essential baseline data that can be used to monitor the health status of western Arctic beluga whales. / Graduate / 0383 / 0329 / 0768 / jpdesforges@gmail.com

The usefulness of secondary exposure and health data to improve public health in South Africa will be assessed. Given the tremendous health impact of air pollution exposure the focus of this thesis is on primary prevention, that is the identification of outdoor air pollution and the use of dirty fuels (wood, animal dung, crop residues, coal, paraffin) for cooking and heating as risk factors, whilst controlling for confounding. Hourly averaged outdoor PM10 mass, NO2, NO, SO2, O3 data (1 August 1998 - 31 July 2003) from Cape Town were analysed in a nonparametric Spearman’s Rho correlation analysis to determine the seasonal spatial correlation between the monitoring sites. Trend and descriptive analyses were conducted on the outdoor hourly and daily PM10 mass data to investigate the current and future health implications in the Khayelitsha sub-district, Cape Town. The 1998 South African Demographic and Health Survey (SADHS) data were analysed. The survey involved 13 826 individuals in 12763 households. Univariate and multivariate logistic regression analyses generated crude and adjusted odds ratios and 95% confidence intervals in order to assess the influence of dirty fuel use for cooking and heating on adult (> 15 years) respiratory health, childhood (< 59 months) respiratory health and 1-59 month mortality. It was found that outdoor air pollution is not homogenously distributed in Cape Town during all seasons. Elevated PM10 mass concentrations are frequently present in the Khayelitsha sub-district. There is a strong case for acknowledging the large public health risk arising from air pollution exposure in South Africa, despite the limitations of the 1998 SADHS data. Not much progress has been made in air pollution epidemiology in the country during this investigation due to the identified limitations. Secondary exposure and health data are thus only useful in improving public health in South Africa by supplying baseline data for trend analysis or hypotheses generation. It is recommended that the country must develop environmental public health tracking networks, which incorporates various data sources from multi-sectoral collaborative intervention projects with analytic study designs, in all major cities in the country. / Thesis (PhD)--University of Pretoria, 2006. / School of Health Systems and Public Health (SHSPH) / PhD / Unrestricted

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第22060号 / 工博第4641号 / 新制||工||1724(附属図書館) / 京都大学大学院工学研究科都市環境工学専攻 / (主査)教授 高野 裕久, 教授 米田 稔, 准教授 上田 佳代 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DFAM

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