61 |
Role of the hERG-channel in arrhythmia and teratogenicity studies in animal models and the human embryonic heart /Danielsson, Christian, January 2010 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2010.
|
62 |
Regeneration of Cryoinjury Induced Necrotic Heart Lesions in Zebrafish Is Associated with Epicardial Activation and Cardiomyocyte ProliferationWeidinger, Gilbert, Schnabel, Kristin, Wu, Chi-Chung, Kurth, Thomas 07 January 2016 (has links)
In mammals, myocardial cell death due to infarction results in scar formation and little regenerative response. In contrast, zebrafish have a high capacity to regenerate the heart after surgical resection of myocardial tissue. However, whether zebrafish can also regenerate lesions caused by cell death has not been tested. Here, we present a simple method for induction of necrotic lesions in the adult zebrafish heart based on cryoinjury. Despite widespread tissue death and loss of cardiomyocytes caused by these lesions, zebrafish display a robust regenerative response, which results in substantial clearing of the necrotic tissue and little scar formation. The cellular mechanisms underlying regeneration appear to be similar to those activated in response to ventricular resection. In particular, the epicardium activates a developmental gene program, proliferates and covers the lesion. Concomitantly, mature uninjured cardiomyocytes become proliferative and invade the lesion. Our injury model will be a useful tool to study the molecular mechanisms of natural heart regeneration in response to necrotic cell death.
|
63 |
Calcium regulation in coronary smooth muscle mechanisms of cardioprotection /Wamhoff, Brian R. January 2001 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2001. / "May 2001." Typescript. Vita. Includes bibliographical references (leaves 176-195). Also available on the Internet.
|
Page generated in 0.0441 seconds