Global ETD Search

21	L-carnitine palmitoyltransferases Derrick, Jeremy Paul January 1988 (has links) No description available. 572 Hepatic fatty acid oxidation
22	Function of tissue inhibitor of metalloproteinase-1 in liver fibrosis Pickering, Judith Ann January 1998 (has links) No description available. 615.1 Transgenics; Hepatic stellate cell
23	Investigation into bone matrix proteins of selected teleost fish Lehane, David Bernard January 1997 (has links) No description available. 572
24	TGF-β expression in solid organ transplantation : a comparative study between cyclosporin A and Tacrolimus Mohamed, Mostafa A. S. January 2000 (has links) No description available. 610
25	A Novel Gene Rogdi Regulates Proliferation, Migration and Activation of Rat Hepatic Stellate Cells Liu, Ren-Chao 09 September 2009 (has links) Rogdi was a novel gene with unknown function. According to GeneBank database, the gene is located on chromsome 10q12 and the length of coding regeion is 864 bp that encods 287 animo acids. Earlier studies in our laboratory showed that human ROGDI influenced rate of cell proliferaion in HeLa, Hep3B and NIH3T3 cells. In addition, we found Rogdi protien was up-regulated in fibrotic livers. Following various types of injury to liver, quiescent hepatic stellate cells (HSCs) transform to activated phenotype, leading to exprssion of £\-SMA, increasing rate of cell proliferation and depositing of extracellular matrix. In this study, we found that Rogdi protein was up-regulated in activated HSCs isolated and cultured from rat livers. By either overexpression or RNA interference of Rogdi, we found that Rogdi affected rate of HSCs proliferation, and expressions of £\-SMA and collagen type I. Expression of Rogdi protein was induced after PDGF treatment of rat HSCs. Additionally, we found that Rogdi was involved in MAPK and PI3K/Akt pathways. Furthermore, using wound healing assay and migration assay, Rogdi was found to regulate migration of activated HSCs. hepatic stellate cells fibrotic liver
26	Studies on the induction of hepatic xenobiotic metabolising enzymes in rodents : Relevance to nodule formation Collins, M. A. January 1985 (has links) No description available. 572 Rodent hepatic nodule formation
27	Increase of glucose and lactate output and decrease of flow by human anaphylatoxin C3a but not C5a in perfused rat liver Püschel, Gerhard P., Oppermann, Martin, Muschol, Waldemar, Götze, Otto, Jungermann, Kurt January 1989 (has links) The complement fragments C3a and C5a were purified from zymosan-activated human serum by column chromatographic procedures after the bulk of the proteins had been removed by acidic polyethylene glycol precipitation. In the isolated in situ perfused rat liver C3a increased glucose and lactate output and reduced flow. Its effects were enhanced in the presence of the carboxypeptidase inhibitor DL-mercaptomethyl-3-guanidinoethylthio-propanoic acid (MERGETPA) and abolished by preincubation of the anaphylatoxin with carboxypeptidase B or with Fab fragments of an anti-C3a monoclonal antibody. The C3a effects were partially inhibited by the thromboxane antagonist BM13505. C5a had no effect. It is concluded that locally but not systemically produced C3a may play an important role in the regulation of local metabolism and hemodynamics during inflammatory processes in the liver. Hepatic glucose balance Hepatic lactate balance Hepatic hemodynamics Complement system Anaphylatoxin Life sciences
28	Phospholipase D1 : a possible role in nucleotide-mediated hepatic stellate cell contraction Benitez-Rajal, Joaquin January 2001 (has links) No description available. 572
29	Analysis of local T cell responses in experimental visceral leishmaniasis Sanchez-Silva, Martin Antonio January 2000 (has links) No description available. 610
30	Investigation into the potential of tissue-specific promoters for gene supplementation therapy Trainer, Alison H. January 1999 (has links) No description available. 572.8

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