High school yoga programs are gaining popularity throughout the United States. The many perceived benefits of such programs among adolescent groups have shown promising outcomes. This mixed-method evaluation of a high school yoga program aims to evaluate the effects of the program on student-reported stress, resilience, and academic outcomes. Program participants include high school students in yoga classes (n = 61) and comparison classes (n = 37), who completed pre- and post-measure surveys along with social validity measures. Overall findings showed a decrease in stress levels among yoga students compared to comparison students, which approached statistical significance, no significant differences between groups on the resilience and academic measures, and high social validity among teachers and students in yoga classes. Future research should include larger sample sizes, interrater reliability for fidelity ratings of yoga practice, and compare yoga to other forms of students' physical activity.