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1	Transgenic Overexpression of CTRP3 Does Not Prevent Alcohol Induced Hepatic Steatosis in Female Mice Thomas, Kristy L., Root, Callie L., Peterson, Jonathan M. 01 January 2022 (has links) Alcoholic liver disease (ALD) is one of the leading causes of morbidity and mortality from hepatic complications. C1q/TNF-related protein 3 (CTRP3) is an adiponectin paralog and, in male mice, increased levels of circulating CTRP3 prevents ALD. Therefore, the purpose of this study was to replicate the observed hepatoprotective effect of elevated circulating CTRP3 levels in female mice. Twelve-week-old female wildtype and CTRP3 overexpressing transgenic mice were fed the Lieber-DeCarli alcohol-containing liquid diet (5% vol/vol) for 6 weeks. Unlike the previous study with male mice, CTRP3 overexpression provided no attenuation to alcohol-induced hepatic lipid accumulation, cytokine production, or overall mortality. In conclusion, there appears to be a clear sex-specific effect of CTRP3 in response to alcohol consumption that needs to be explored further. adipokines (genetics metabolism) adiponectin (metabolism) animals diet high-fat (adverse effects) ethanol (adverse effects metabolism) fatty liver (chemically induced genetics physiopathology) fatty liver alcoholic (metabolism) female gene expression (genetics) lipid metabolism (drug effects) liver (metabolism pathology) male mice mice inbred C57BL mice transgenic obesity (metabolism) tumor necrosis factors (genetics metabolism) Health Sciences

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Transgenic Overexpression of CTRP3 Does Not Prevent Alcohol Induced Hepatic Steatosis in Female Mice