In his projected cycle, The Voyage That Never Ends, Malcolm Lowry intended an investigation of the journey undertaken by man's unconscious as he struggles with his basic impulses towards love and destruction, and with his relationships with his fellow-man and God. Lowry designed his cycle of fiction with a structure parallel to that of Dante's Divine Comedy. While this study is also structured according to Lowry's Dantean concept, it does not simply analyse the references to Dante. Lowry's fiction is founded upon a vast and complex network of symbolic and mythic allusion, by which themes are underpinned on numerous levels. Allusions to this body of symbolic material - what is termed the "symbolic legacy" - are also incorporated into the motifs of the author's works. Thus Lowry's references are to no single tradition in literature; the symbols and myths are drawn from numerous sources including the Classical, Mystical/Cabbalistic, Christian and Romantic traditions, and from Modernist reworkings of these traditions. This study, therefore, represents an analysis of the references employed by Lowry, and the relating of the various traditions which are used as sources of allusion. While Under the Volcano contains the fullest exposition of Lowry's symbolic patterning, other works contain further evidence of his endlessly reverberating matrix of symbols. The mythopoeic drive is so strong that often several versions of the same myth or symbol are worked into his fiction. This leads to a contradictory exposition of certain thematic concerns. The antitheses established are integral to Lowry's vision of a complex world in which "civilized" man is endangering both himself and his environment and for whom there exists both the possibility of accepting the downward spiral which has been history and, simultaneously, the means to redemption, according to what he aspires to most.

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Healthcare around the world is facing strenuous times, whereby there is a need for reduced costs, improved efficiency, and effectiveness. Digitalization is a transformational phenomenon argued to solve the many problems of healthcare. As of such, this thesis studies digitalization in a healthcare setting - considering how digitalization is achieved in practice, and what elements hamper and enable sociotechnical changes required for digitalization. To study these aspects, a qualitative case study was carried out on the recently implemented mandatory electronic dental card among the dental care professionals from a Baltic country. The study allowed contributions to digitalization research by looking at the phenomenon from industry-level analysis, also revealed the elements that hamper and enable digitalization, outlined the different digitalization patterns, and argued that digitalization relies on the extent by which the new system provides value to the users without interfering with professional expertise and ethics.

In this study, we used E. coli strain BL21 (DE3) to express the recombinant protein his-tag streptavidin. To find out the optimal production conditions, we studied on the culture conditions, medium composition, induction conditions and the timing of induction. In the purification processes we tried to find out the difference between hydrophobic column and affinity column. We also tested the effect of heat treatment on the crude extract to increase the recombinant protein yield. The results showed that when cultured in LB medium, the optimal culture conditions of recombinant protein expression are 37¢XC, pH 6.0 to 7.0, and the induction temperature is 37¢XC. The best induction time is at late log phase or the early stationary phase when OD600 values reached to the ranged of 1.1 to 1.8. The inducer, IPTG concentration is 0.1 mM, which can also replaced with 2 mM lactose. The best production medium is TB medium. When cultured in 5 liters fermentor with optimal culture and induction condition, the highest recombinant protein yield could be 81.1 mg /L. To improve the purification process, we used a affinity chromatography. The purified high homogeneous recombinant protein had a high biotin binding activity up to 14 U / mg, and the recovery yield could be as high as 97% in comparing with the hydrophobic column was only 51%. When we treated the crude extract with 75 ¢J for 10 min, the biotin binding activity was 14.1 U / mg, but the recovery rate decreased to 64 %.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / The âMinha Casa Minha Vidaâ (MCMV), which aims to reduce the housing deficit, launched its second phase, with a bold goal to hire two million housing units by the year 2014. While this economic environment encouraged companies in the Construction Industry, they were not adequately prepared to absorb the new demands. To reach them, we need to implement innovations in traditional processes of design and construction of this type of housing, increasing productivity, but without loss of quality of the products generated. The projects related to housing construction have become increasingly complex, and has increased the number of projects needed to better execution of the work, causing serious problems of compatibility and rework. In view of the peculiar characteristics of the enterprises of Social Housing (HIS), the profit margins offered by these are greatly reduced, forcing companies to pursue lower production costs and execution time of compression, in order to minimize the incidence of fixed costs. It is worth noting that the initial stages of development, such as program and project are those that present the greatest opportunities for intervention and value. In some countries, especially the United States, these problems have been minimized through approaches such as Integrated Project Delivery (IPD) and the use of design tools such as the Building Information Modeling (BIM). In turn, the vast majority of projects in Brazil, especially the HIS, are not designed with this in mind integration. Within this context, the aim of this work is to propose guidelines for increasing the level of integrated management for design firms that operate in MCMV (range 0-3 minimum wages), based on the principles of IPD. This is a qualitative study with an exploratory-descriptive and research strategy used was the multiple case study, divided into four phases: literature review, exploratory stage, stage of conducting case studies and step analyzes and propositions . Therefore, we carried out a survey to contextualize the partial results of the program and analyze the role of each of the major players involved. There was a peculiarity in the state of CearÃ: the Sinduscon-Ce provides companies affiliated three types of architectural design, installations and structures (reference projects). We investigated how was the design process of these types and the level of integration between professionals. The main tool for data collection were semi-structured interviews with the designers, with the representative of Box and Sinduscon. Based on these data, we carried out a cross-sectional analysis of business and design, as well as a diagnosis of these assumptions with respect to the IPD. We also propose an adaptation of the principles of IPD directed to designers Finally, the main contribution of this work is to propose guidelines for increasing the level of integrated management between designers working in MCMV, relating them to the principles of IPD . / O Programa Minha Casa Minha Vida (MCMV), que tem por finalidade reduzir o dÃficit habitacional brasileiro, lanÃou sua segunda fase, com uma meta ousada de contratar dois milhÃes de unidades habitacionais atà o ano de 2014. Ao mesmo tempo em que este cenÃrio econÃmico incentivava as empresas da IndÃstria da ConstruÃÃo Civil, estas nÃo estavam adequadamente preparadas para absorver as novas demandas. Para alcanÃÃ-las, à preciso implementar inovaÃÃes nos processos tradicionais de projeto e construÃÃo deste tipo de moradia, aumentando a produtividade, porÃm sem prejuÃzo de qualidade dos produtos gerados. Os projetos ligados à construÃÃo habitacional tÃm se tornado cada vez mais complexos, bem como tem aumentado a quantidade de projetos necessÃrios a uma melhor execuÃÃo da obra, provocando sÃrios problemas de compatibilizaÃÃo e retrabalho. Em face das caracterÃsticas peculiares dos empreendimentos de HabitaÃÃo de Interesse Social (HIS), as margens de lucro proporcionadas por estes sÃo bastante reduzidas, forÃando as empresas a perseguirem menores custos de produÃÃo e a compressÃo dos prazos de execuÃÃo, como forma de minimizar a incidÃncia de custos fixos. Cabe ressaltar ainda que as etapas iniciais do empreendimento, tais como o programa e o projeto, sÃo as que apresentam as maiores oportunidades de intervenÃÃo e agregaÃÃo de valor. Em alguns paÃses, principalmente nos Estados Unidos, estes problemas tÃm sido minimizados atravÃs de abordagens como o Integrated Project Delivery (IPD) e do uso de ferramentas de projeto tais como o Building Information Modeling (BIM). Por sua vez, a grande maioria dos empreendimentos brasileiros, especialmente os de HIS, nÃo sÃo desenvolvidos dentro deste espÃrito de integraÃÃo. Dentro deste contexto, o objetivo deste trabalho à propor diretrizes para aumentar o nÃvel de gestÃo integrada em empresas de projeto que atuam no programa MCMV (faixa de 0-3 salÃrios mÃnimos), com base nos princÃpios do IPD. Trata-se de um estudo qualitativo, com carÃter exploratÃrio-descritivo, e a estratÃgia de pesquisa utilizada foi o estudo de caso mÃltiplo, dividida em quatro fases: pesquisa bibliogrÃfica, etapa exploratÃria, etapa de conduÃÃo dos estudos de caso e etapa de anÃlises e proposiÃÃes. Para tanto, realizou-se um levantamento para contextualizar os resultados parciais do referido programa e analisar o papel de cada um dos principais agentes envolvidos. Verificou-se uma particularidade no estado do CearÃ: o Sinduscon-Ce disponibiliza Ãs empresas filiadas trÃs tipologias de projeto de arquitetura, instalaÃÃes e estruturas (projetos de referÃncia). Investigou-se como se deu o processo de projeto destas tipologias e qual o nÃvel de integraÃÃo entre os profissionais. A principal ferramenta para a coleta de dados foram as entrevistas semiestruturadas com os projetistas, com representante da Caixa e do Sinduscon. Com base nesses dados, realizou-se uma anÃlise cruzada das empresas e projeto, assim como um diagnÃstico destas com relaÃÃo aos postulados do IPD. PropÃe-se ainda uma adaptaÃÃo dos princÃpios do IPD direcionada para os projetistas Por fim, a principal contribuiÃÃo deste trabalho à a proposiÃÃo de diretrizes para aumentar o nÃvel de gestÃo integrada entre os projetistas que atuam no programa MCMV, relacionando-as aos princÃpios do IPD.

Cílem této diplomové práce bylo nastudovat problematiku klasifikačních systémů v nemocnicích, které sledují především hospodářské požadavky hospitalizace. Následně bylo navrženo a naprogramováno webové rozhraní v prostředí Caché Server Pages (CSP), které poskytuje přístup k databázi CLINICOM. Pomocí webového rozhraní, je možno provádět klasifikaci pacientů do tříd MDC (Major Diagnostic Category), archivaci dat, výpočet DRG a další vybrané úkony. Webovou aplikaci by mohli využívat technicko-hospodářští pracovníci nemocnic a klinik jako jednoduchou pomůcku při své práci, respektive jako učební pomůcka biomedicínských oborů pří výuce zdravotnických informačních a klasifikačních systémů.

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