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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Hipoexpressão de miR-205ab e miR-218a associada ao pior prognóstico em pacientes com câncer de mama / Hypoexpression of miR-205ab and miR-218a was associated with the worst prognosis in patients with breast cancer

Paes, Juliana Fracalossi 27 September 2018 (has links)
Submitted by Franciele Moreira (francielemoreyra@gmail.com) on 2019-01-31T13:01:42Z No. of bitstreams: 2 Dissertação - Juliana Fracalossi Paes - 2018.pdf: 3499755 bytes, checksum: 913f34f36a97b5b7412e4eec7b1af1c1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2019-02-01T10:04:10Z (GMT) No. of bitstreams: 2 Dissertação - Juliana Fracalossi Paes - 2018.pdf: 3499755 bytes, checksum: 913f34f36a97b5b7412e4eec7b1af1c1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2019-02-01T10:04:10Z (GMT). No. of bitstreams: 2 Dissertação - Juliana Fracalossi Paes - 2018.pdf: 3499755 bytes, checksum: 913f34f36a97b5b7412e4eec7b1af1c1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2018-09-27 / Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG / Introduction: MicroRNAs are small molecules of single-stranded non-coding RNAs that regulate gene expression in the post-transcriptional phase and are being evaluated as prognostic and predictive markers in breast cancer. Objective: The aim of this study was to evaluate the expression of hsa-miR-205ab and hsa-miR-218a microRNAs and BRCA1 protein in breast cancer samples and their associations with the pathological and prognostic clinical aspects of tumors. Method: A group of 92 breast cancer cases was evaluated for clinical-pathological aspects, five-year survival, expression of BRCA1, hsa-miR-205ab and hsa-miR-218a. BRCA1 expression was assessed by immunohistochemistry and the quantification of the miRNAs by quantitative PCR in real time. The clinical-pathological aspects were compared in relation to the expression of BRCA1, hsa-miR- 205ab and hsa-miR-218a using the Mann-Whitney test. Survival curves were generated by the Kaplan-Meyer method and compared by the long-rank method. Results: The group of tumors comprised 56 cases of non-triple-negative breast carcinomas and 36 tumors with triple-negative phenotype. Hypoexpression of hsa-miR-205ab and hsa-miR-218a was associated with larger tumors (> 2 cm), presence of lymph node metastasis and distant metastasis, the highest histological grade, triple negative phenotype, absence of expression of BRCA1 and lower survival. (P = 0.044), more advanced stages (p = 0.005), lymph node involvement (p = 0.038), presence of distant metastasis (p = 0, 0008) and absence of BRCA1 expression (p = 0.039). Conclusion: The hypoexpression of hsa-miR-205ab and hsa-miR-218a was associated with factors of poor prognosis, absence of BRCA1 expression and the lowest survival rate in breast cancer patients evaluated in this study. / Introdução: Os microRNAs são pequenas moléculas de RNAs não-codificantes de cadeia simples, que regulam a expressão gênica na fase pós-transcricional e vem sendo avaliados como marcadores prognósticos e preditivos no câncer de mama. Objetivo: O objetivo deste estudo foi avaliar a expressão dos microRNAs hsa-miR-205ab e hsa-miR-218a e da proteína BRCA1 em amostras de câncer de mama e suas associações com os aspectos clínico patológicos e prognósticos dos tumores. Método: Um grupo de 92 casos de câncer de mama foi avaliado quanto aos aspectos clínico-patológicos, a sobrevida em cinco anos, a expressão de BRCA1, hsa-miR-205ab e hsa-miR-218a. A expressão de BRCA1 foi avaliada por imuno- histoquímica e a quantificação dos miRNAs por PCR quantitativa em tempo real. Os aspectos clínicos-patológicos foram comparados em relação à expressão de BRCA1, hsa-miR-205ab e hsa-miR-218a, utilizando o teste de Mann-Whitney. As curvas de sobrevida foram geradas pelo método de Kaplan-Meyer e comparadas pelo método de long-rank. Resultados: O grupo de tumores compreendeu 56 casos de carcinomas de mama não triplo-negativos e 36 tumores com fenótipo triplo-negativo. A hipoexpressão de hsa-miR-205ab e hsa-miR-218a foi associada aos tumores maiores (> 2 cm), à presença de metástase linfonodal e de metástase a distância, ao grau histológico mais elevado, fenótipo triplo negativo, ausência de expressão de BRCA1 e menor sobrevida. A sobrevida das pacientes em função das características clínico patológicas foi influenciada pelo fenótipo triplo-negativo (p=0,044), estádios mais avançados (p=0,005), acometimento linfonodal (p=0,038), presença de metástase à distância (p=0,0008) e ausência da expressão de BRCA1 (p=0,039). Conclusão: A hipoexpressão de hsa-miR-205ab e hsa-miR-218a foi associada aos fatores de pior prognóstico, ausência de expressão de BRCA1 e à menor sobrevida nas pacientes com câncer de mama avaliadas neste estudo.

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