Global ETD Search

1	Evaluation et prise en charge des anomalies foetales du rein et du tractus urinaire Ismaili, Khalid January 2006 (has links) Doctorat en Sciences médicales / info:eu-repo/semantics/nonPublished Médecine pathologie humaine Kidneys -- Abnormalities -- Diagnosis Reins -- Malformations -- Diagnostic
2	Meckelin 3 is Necessary for Photoreceptor Outer Segment Development Hudson, Scott R. 03 July 2012 (has links) Indiana University-Purdue University Indianapolis (IUPUI) / Ciliopathies with multiorgan pathology include renal cysts and eye pathology. Previous studies showed meckelin (MKS3 protein product) are crucial to cilia function and its absence in Wpk rats (with mutated rMks3 gene) causes Leber's congenital amaurosis. Retinal photoreceptors have connecting cilium that joins the inner to the outer segment and plays a role in the transport of molecules necessary for morphological and molecular development and maintenance of the outer segment process. The present study evaluated meckelin expression during normal postnatal retinal development and the consequences of mutant meckelin on photoreceptor development and survival in Wistar-Wpk/Wpk rat. Meckelin was co-expressed in photoreceptors, amacrine, Muller glia and ganglion cells in postnatal day 10 (P10) and P21 wild type retinae. Meckelin was detected in both inner and outer segments of photoreceptors. By P10, both wild type and homozygous Wpk mutant retina had all retinal cell types. In contrast, by P21, cells expressing photoreceptor-specific markers in the Wpk mutant were fewer in number with abnormal expression patterns. Cell death assays confirmed a significant amount of cells undergoing apoptosis in the outer nuclear layer of the mutant rat retina. By electron microscopy, mutant photoreceptors did not develop an outer segment process beyond a connecting cilium and rudimentary outer segment. We conclude that MKS3 is not important for formation of connecting cilium and rudimentary outer segments, but is critical for the elongation and/or maintenance of mature outer segment processes. meckelin photoreceptors cell death Photoreceptors Cell death Multiple organ failure Eye -- Pathophysiology Eye -- Diseases -- Genetic aspects Kidney, Cystic Abnormalities, Human -- Diagnosis
3	Respiratory Infections in Ambulatory Adults. Choosing the Best Treatment Perlman, P E., Ginn, D R. 01 January 1990 (has links) The diagnosis and treatment of respiratory tract infections in ambulatory adults is challenging. The prevalence of these conditions outstrips the medical profession's efficiency and effectiveness in dealing with them. However, selecting diagnostic techniques that identify causative organisms and therapeutic agents targeted to those organisms should lead to a reduction in the morbidity and mortality associated with these illnesses. adult aged ambulatory care anti-bacterial agents (therapeutic use) bronchitis (diagnosis drug therapy etiology) child common cold (diagnosis etiology prevention & control therapy) diagnosis differential epiglottitis (diagnosis) humans influenza human (diagnosis etiology prevention & control therapy) middle aged otitis media (diagnosis drug therapy) pharyngitis (diagnosis drug therapy etiology) pneumonia (diagnosis therapy) respiratory tract infections (diagnosis etiology therapy) sinusitis (diagnosis drug therapy etiology) virus diseases (complications) QCOM

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