Akademisk avhandling--Gothenburg. / Bibliography: p. 69-74.

Hyperbaric Oxygenation Therapy (HBOT) has a successive history for treating very specific groups of physical conditions. Research by Neubauer and colleagues states that HBOT's ability to increase cerebral metabolism in the brain regenerates dormant neural tissue (Neubauer, Gottlieb, & Pevsner 1994). According to this research, the increase of cerebral metabolism levels restores mental capacity from the neurological insult. Despite promise, uncertainty exists as to whether this is a viable treatment option for people suffering from neural damage. The research results for this experiment will examine the effect of HBOT on cerebral metabolism levels in adults and pediatrics with chronic neurological problems. Fifty individuals diagnosed as having a neurological impairment whom met criteria for the study were analyzed from an archival data set. Criterion required chronic impairment, baseline SPECT, followed by HBOT exposures, and a post SPECT scan. Statistical analyses consisted of a Pearson correlation that examined pre-metabolism rates with total change, a Pearson correlation that examined total change and number of treatments, and a one way ANOVA analysis that examined cerebral metabolism change in patients under 18 and over 18. Results indicated change

This study investigated the effects of hyperbaric oxygen (HBO) therapy on acute ankle injuries and determined if HBO therapy shortened time to recovery, decreased edema and pain, and increased range of motion and strength of the ankle. Subjects were randomly assigned to either an experimental (HBO) group (n = 4) or a control group (n = 4). All subjects received the same standardized physical therapy for lateral ankle sprains at the McGill Sport Medicine Clinic. The HBO group received 5 consecutive HBO treatments at 2.5 ATA for 90 minutes starting within 24 hours post injury. The control group received no HBO treatments. All subjects were evaluated by a physician within 24 hours of injury. All subjects suffered a second-degree lateral ankle sprain. Pain, range of motion, strength, volume displacement, and function were evaluated on the day of injury (Day 1), on Day 6 post injury, and on the day of return to play (Day RTP). There was no significant difference in time to return to play. However, the HBO group (25.5 +/- 11.6 days) did return 31% faster than the control group (36.8 +/- 19.4 days). There were no differences found between groups on the variables. There was a decrease in pain found over time (Day 1 was 57 mm, Day 6 was 18.5 mm, and Day RTP was 7 mm). The results of this study suggest that with treatment of HBO there is no effect on ankle sprains for return to play or improved function.

Thesis Ph. D.)(Chemical Engineering)--University of Pretoria, 2003. / Title from opening screen (viewed Oct. 06, 2004). Summaries in English and Afrikaans. Includes bibliographical references (leaves 144-151).

Thesis (Ph. D.)--University of Chicago, Dept. of Radiology, August 2000. / Includes bibliographical references. Also available on the Internet.

No description available.

Thesis--Copenhagen University. / Summary in Danish. Includes bibliographical references (p. 96-120).

Thesis--Copenhagen University. / Summary in Danish. Includes bibliographical references (p. 96-120).

Procurou-se confirmar a existência de alterações estruturais em corpos carotídeos de ratos expostos à hiperóxia que pudessem explicar a atenuação da resposta fisiológica à hipóxia nessas condições descrita na literatura. Também testamos a hipótese de haver um desvio de fluxo sanguíneo para os capilares intraglômicos em situações de hiperoxigenação hiperbárica.15 ratos machos Wistar adultos foram divididos em 3 grupos e expostos a 2,4 ATA por 6 horas, a 3,0 ATA por 6 horas e a ar ambiente (grupo controle). Os resultados obtidos através de análise histológica e morfométrica mostraram: a) nenhuma alteração da arquitetura dos corpos carotídeos, mas as células expostas à dose mais elevada apresentaram-se com citoplasma desarranjado, confirmado pela microscopia eletrônica; b) um aumento significativo da densidade volumétrica de capilares preenchidos por hemácias, mas não do estroma intersticial, no grupo exposto à dose mais elevada de O2 c) uma vasoconstricção significativa das arteríolas maiores em todas as doses de oxigênio empregadas no estudo e das arteríolas menores na dose mais elevada de O2; d) variações significativas na proporção das variantes de células glômicas no grupo exposto a menor dose de O2; e) mitocôndrias com poucas cristas, tanto nas células glômicas quanto nas terminações nervosas, embora nas primeiras apresentem-se bem deformadas; f) proliferação membranosa citoplasmática com aumento de REG e Golgi nas células glômicas e sustentaculares. Esses resultados sugerem um desvio do fluxo dos vasos mais calibrosos em direção aos capilares intraglômicos, confirmando nossa hipótese inicial e indicam que o oxigênio, dependendo da dose utilizada, exerce um efeito tóxico importante sobre os corpos carotídeos, com alterações significativas da ultraestrutura das células glômicas e terminações nervosas. / We sough to confirm the existence of structural alterations in rat carotid bodies exposed to hyperoxia that could explain the attenuation of the ventilatory hypoxic drive (HD) by hyperoxic conditions described in the literature. We also tested the hypothesis of there being a deviation of blood flow toward intraglomic capillaries in situations of hyperbaric oxygenation (HBO).15 adult male Wistar rats were divided in 3 groups and exposed to O2 at 2.4 ATA for 6 hours, at 3.0 ATA for 6 hours and to air at 1.0 ATA (control group). The results obtained through histological and morphometric analysis showed: a) no alteration in the architecture of the carotid bodies, but the cytoplasm of the cells exposed to the highest dose were disarranged, a feature confirmed by electron microscopy; b) a significant increase in volume density of capillaries filled out by red blood cells but not of interstitial stroma in the group exposed to O2 at the highest dose; c) a significant vasoconstriction of larger arterioles in all doses of oxygen employed in the study and of smaller arterioles at the highest dose of O2; d) significant variations in the proportion of glomic cell variants in the group exposed to the lowest dose of O2; e) mitochondria with few cristae, so in glomic cells as in nerve-endings, although in the former they were very deformed; f) cytoplasmic membranous proliferation with an increase of endoplasmic reticulum and Golgi apparatus in glomic and sustentacular cells. These results suggest a deviation of blood flow from more calibrated vessel toward intraglomic capillaries, confirming our initial hypothesis and indicate that oxygen, depending on the dose used, exerts an important toxic effect on rat carotid body with significant alterations of glomic cell and nerve-endings ultrastructure.

O objetivo deste trabalho foi avaliar os efeitos do monossialogangliosídio (GM1), da câmara de oxigenoterapia hiperbárica e de ambos no tratamento da lesão medular experimental em ratos. Trinta e dois ratos Wistar com lesão medular foram divididos em 4 grupos: um grupo recebeu o monossialogangliosídio (GM1), um segundo foi submetido à oxigenoterapia hiperbárica, um terceiro recebeu os dois tratamentos e um quarto não recebeu tratamento (controle). Não houve diferença significativa entre os grupos na análise histológica, em todas as variáveis (necrose, hemorragia, hiperemia e degeneração cística, p>0,06). Também não houve nenhuma diferença na comparação entre os lados direito e esquerdo nos testes funcionais (p>0,06 para todos). Não foram encontradas diferenças nos testes motores, na comparação entre os grupos após 2, 7 21 e 28 dias de lesão medular. Mas, na avaliação após 14 dias, o Grupo 3, o qual recebeu a terapia combinada, mostrou um escore BBB significantemente maior que os outros grupos (p=0,015). Na avaliação de 28 dias, houve uma tendência dos Grupos 1 (GM1) e 3 (terapia combinada) apresentarem um escore BBB maior que o do Grupo 4 (controle), embora sem significância estatística (p=0,057). Concluiu-se que, quanto aos índices motores, a utilização do GM-1 tem efeito benéfico, embora sem diferença estatisticamente significante e que o efeito benéfico do GM-1 é antecipado através da utilização concomitante da oxigênio terapia hiperbárica. / The objectives were to evaluate the effect of GM1 ganglioside, hyperbaric oxygen, and both in combination, in the treatment of experimental spinal cord lesions in rats. Thirty-two Wistar rats with spinal cord lesions were divided into four groups: one group received GM1 ganglioside, one was submitted to hyperbaric oxygen therapy, the third received both treatments, and the fourth received no treatment (control). There were no significant differences between the groups in the histological analysis, for any of the variables (necrosis, hemorrhage, hyperemia, cystic degeneration, p > 0.06). Neither were there any significant differences in the comparison of left and right sides in the functional tests (p > 0.06 for all). No significant differences were found in the locomotor ratings, in the comparison of groups at 2 days, 7 days, 21 days and 28 days after the surgical procedure. However, in the evaluation on day 14, Group 3, which received the combined therapy, showed a significantly higher BBB score than the other groups (p = 0.015). In the evaluation on day 28, there was a trend to Group 1 (GM1) and 3 (combined therapy) showed a higher BBB score than the group 4 (control), but with no significance (p=0,057). In conclusion, the is a benefit in the use of GM1 ganglioside, but with no significance and the therapeutic effect of GM1 in locomotor evaluation of rats submitted to spinal cord lesion is anticipated by hyperbaric oxygen therapy.