Made available in DSpace on 2014-06-11T19:25:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-11-13Bitstream added on 2014-06-13T19:52:57Z : No. of bitstreams: 1 santos_ktp_me_botfm.pdf: 2016274 bytes, checksum: 10c5208275a20377aa85de57b31db871 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação para o Desenvolvimento Médico e Hospitalar (Famesp) / Os autores têm descrito a incidência de perda auditiva em torno de 25% no hipotireoidismo. Estudar a acuidade auditiva, os sintomas cocleovestibulares e os cofatores de risco no hipotireoidismo. Grupo amostral (GA, n-30), pacientes com hipotireoidismo adquirido; grupo controle (GC, n-30), voluntários, sem distúrbios da glândula tireóidea. Parâmetros: idade, gênero, tempo de diagnóstico do hipotireoidismo, comorbidades, sintomas cocleovestibulares, resultados dos exames bioquímicos e hormonais, audiometria tonal limiar, EOAet e PEATE.Todos os participantes eram do sexo feminino. Em ambos os grupos, a faixa etária predominante foi entre 31 a 50 anos. A maioria dos pacientes do GA apresentava o diagnóstico de hipotireoidismo há menos de cinco anos. As comorbidades mais freqüentes do GA foram depressão e a hipertensão. Sintomas cocleovestibulares foram mais freqüentes em GA (76,7%) contra 26,7% de GC. Valores de glicemia de jejum pouco elevados foram registrados em 40% de GA e em 10% de GC; valores, discretamente elevados de triglicérides e de colesterol foram observados em ambos os grupos. Em 22 orelhas do GA e sete do GC os limiares audiométricos estavam alterados, caracterizando perda auditiva leve e sensorioneural. As alterações observadas nas avaliações audiológicas não se relacionaram com os níveis glicêmicos, lipídicos ou hormonais. O PEATE mostrouse alterado em 10 orelhas de GA (oito dos quais com audiometria também alterada) notando-se, principalmente prolongamento de LAV. As EOAet estiveram ausentes em 12 orelhas do GA e em quatro do GC. Sintomas cocleovestibulares e alterações nos exames de audiometria tonal limiar, PEATE e EOAet foram mais freqüentes nos pacientes portadores de hipotireoidismo. / Authors have been reported incidence around 25% of hearing loss in hypothyroidism. The physiopathology, risk cofactors, and lesion sites are still unclear. To study hearing acuity, cochleovestibular symptoms, and risk co factories in hypothyroidism. GA (n-30) patients with acquired hypothyroidism; GC (n=30) controls. Parameters: age, gender, time of diagnosis, comorbidities, cochleovestibular symptoms, biochemical and hormonal exams, audiometry, BERA and TOAEs. Results: All participants were female. The predominant age in both groups was 31 to 50 years. Most GA patients had less than 5 years hypothyroidism diagnosis. The commonest GA comorbidities were depression and hypertension. Cochleovestibular symptoms were more frequent in GA (76.7% versus 26.7%). Mild elevation fasting glycemia values occurred in 40% GA and 10% GC; elevated triglyceride and cholesterol levels were observed in both groups. Altered audiometry was found in 22 GA and 7 GC ears showing mild neurosensorial hearing loss. BERA was altered in 10 GA ears (eight of which also had altered audiometry), mainly prolonged LAV. TOAEs was absent in 12 GA and 4 GC ears. Cochleovestibular symptoms and alterations in the audiometry, BERA and TOAEs exams were more frequent in hypothyroidism patients.

Class of 2006 Abstract / Background: Approximately 2% of the population has hypothyroidism, and are treated with a levothyroxine product. Unlike other medications, levothyroxine products have not been considered substitutable due to their narrow therapeutic window. Objectives: To compare the bioequivalence study findings from studies conducted by the manufacturer of Synthroid to those conducted by other investigators. Methods: Studies comparing levothyroxine product bioequivalence were found and divided according to time period, study design, and major funding party. Results: Ten studies excluded due to a change in Synthroid formulation. Six steady state studies and 3 single dose studies were left. Conclusions: Although data suggests bioequivalence between all studied levothyroxine products, there was not enough data to make a conclusion.

Hypothyroidism is the most common endocrine disease in dogs and has been shown to have a hereditary nature in many breeds. Previous studies have documented decreased fertility in bitches with experimentally-induced hypothyroidism, decreased viability at birth, increased periparturient mortality, and reduced birth weight in pups born to hypothyroid dogs. Hypothyroid women have an increased demand for exogenous thyroxine throughout gestation in order to maintain normal plasma concentrations of thyroid hormones and produce neuropsychologically normal children. This study was performed to determine if pregnancy causes a similar need for increased levothyroxine dosages in dogs to maintain a euthyroid state. Serum was harvested from blood collected from six bitches with experimentally-induced hypothyroidism that were receiving standard thyroid hormone replacement therapy and from four euthyroid control bitches. Thyroid function tests performed on these samples included total thyroxine (T4), free T4 (FT4), thyroid stimulating hormone (TSH), and 3,5,3'-triiodinine (T3). Thyroid concentrations were measured from ovluation through the end of pregnancy. All bitches whelped normal litters. Euthyroid bitches had no significant alterations in their hormone concentrations throughout pregnancy. None of the supplemented hypothyroid bitches had clinical signs of hypothyroidism throughout the study. Serum concentrations of T4 and FT4 were elevated at multiple sample points during gestation. The results from this study indicate that standard levothyroxine supplementation is adequate to maintain a euthyroid state during pregnancy in experimentally-induced hypothyroid dogs. In addition, there is no evidence that canine thyroid profiles in euthyroid dogs are altered during gestation. / Master of Science

Indiana University-Purdue University Indianapolis (IUPUI) / This study was undertaken to histologically evaluate orthodontic tooth movement in hypothyroid and in normal Macaque speciosa monkeys. The experimental animals were rendered hypothyroid by radiosurgically altering the thyroid gland. A clinically acceptable orthodontic force was delivered to the anterior teeth of the monkeys. After the desired movement, a histologic investigation was made to correlate tissue responses with pressure, tension and root resorption. There was no significant difference among the three experimental animals. Likewise, there was no significant difference between the control animal and the three experimental animals. Osteoblastic and osteoclastic activity occurred to a comparable degree in both the experimental and control animals and was within normal limits for the amount of orthodontic tooth movement achieved. Root resorption was evident in both orthodontically treated and non-treated teeth in both the experimental and control animals. The root resorption observed was not significantly different, quantitatively or strategically, between the experimental and the control animals. Repair of root resorption was evident in both the experimental and control animals.

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Thesis (M.S.)--Bowling Green State University, 2009. / Document formatted into pages; contains vii, 44 p. : ill. Includes bibliographical references.

Resumo: Os autores têm descrito a incidência de perda auditiva em torno de 25% no hipotireoidismo. Estudar a acuidade auditiva, os sintomas cocleovestibulares e os cofatores de risco no hipotireoidismo. Grupo amostral (GA, n-30), pacientes com hipotireoidismo adquirido; grupo controle (GC, n-30), voluntários, sem distúrbios da glândula tireóidea. Parâmetros: idade, gênero, tempo de diagnóstico do hipotireoidismo, comorbidades, sintomas cocleovestibulares, resultados dos exames bioquímicos e hormonais, audiometria tonal limiar, EOAet e PEATE.Todos os participantes eram do sexo feminino. Em ambos os grupos, a faixa etária predominante foi entre 31 a 50 anos. A maioria dos pacientes do GA apresentava o diagnóstico de hipotireoidismo há menos de cinco anos. As comorbidades mais freqüentes do GA foram depressão e a hipertensão. Sintomas cocleovestibulares foram mais freqüentes em GA (76,7%) contra 26,7% de GC. Valores de glicemia de jejum pouco elevados foram registrados em 40% de GA e em 10% de GC; valores, discretamente elevados de triglicérides e de colesterol foram observados em ambos os grupos. Em 22 orelhas do GA e sete do GC os limiares audiométricos estavam alterados, caracterizando perda auditiva leve e sensorioneural. As alterações observadas nas avaliações audiológicas não se relacionaram com os níveis glicêmicos, lipídicos ou hormonais. O PEATE mostrouse alterado em 10 orelhas de GA (oito dos quais com audiometria também alterada) notando-se, principalmente prolongamento de LAV. As EOAet estiveram ausentes em 12 orelhas do GA e em quatro do GC. Sintomas cocleovestibulares e alterações nos exames de audiometria tonal limiar, PEATE e EOAet foram mais freqüentes nos pacientes portadores de hipotireoidismo. / Abstract: Authors have been reported incidence around 25% of hearing loss in hypothyroidism. The physiopathology, risk cofactors, and lesion sites are still unclear. To study hearing acuity, cochleovestibular symptoms, and risk co factories in hypothyroidism. GA (n-30) patients with acquired hypothyroidism; GC (n=30) controls. Parameters: age, gender, time of diagnosis, comorbidities, cochleovestibular symptoms, biochemical and hormonal exams, audiometry, BERA and TOAEs. Results: All participants were female. The predominant age in both groups was 31 to 50 years. Most GA patients had less than 5 years hypothyroidism diagnosis. The commonest GA comorbidities were depression and hypertension. Cochleovestibular symptoms were more frequent in GA (76.7% versus 26.7%). Mild elevation fasting glycemia values occurred in 40% GA and 10% GC; elevated triglyceride and cholesterol levels were observed in both groups. Altered audiometry was found in 22 GA and 7 GC ears showing mild neurosensorial hearing loss. BERA was altered in 10 GA ears (eight of which also had altered audiometry), mainly prolonged LAV. TOAEs was absent in 12 GA and 4 GC ears. Cochleovestibular symptoms and alterations in the audiometry, BERA and TOAEs exams were more frequent in hypothyroidism patients. / Orientador: Regina Helena Garcia Martins / Coorientador: Glaucia M. F. S. Mazeto / Banca: Onivaldo Bretan / Banca: Marco Aurélio Bottino / Mestre

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