Philosophiae Doctor - PhD / The progressive development of scintillator detectors has made it possible to perform direct electronic lifetime determination up to a few hundred nanoseconds. The 2" by 2" LaBr3:Ce detectors provide a combination of excellent time resolution and good energy resolution. Recently a fast timing array has been commissioned at iThemba LABS, Cape Town consisting of eight 2" by 2" LaBr3:Ce detectors. Test measurements using radioactive sources produced at the laboratory were conducted. Six 2" by 2" LaBr3:Ce detectors were coupled to the AFRODITE array as their rst in-beam experiment. AFRODITE consisted of eight HPGe clover detectors as well as two 3.5" x 8" LaBr3:Ce detectors. A particle telescope was used to select the desired reaction channels. The reactions of interest 45Sc(p,d)44Sc and 45Sc(p, )42Ca were carried out at a beam energy of 27 MeV. The current analysis also investigates the rare earth nucleus 150Gd which was populated through 150Sm( ,4n)150Gd at a beam energy of 48 MeV.

This first detailed description of the pathology of tuberculosis, caused by Mycobacterium tuberculosis in springbok is reported. The springbok were part of a semi free-ranging herd kept on the grounds of iThemba Laboratory for Accelerator Based Science (LABS) in the Kuils River district of the Western Cape Province, South Africa. Of the 33 animals sampled, two animals had tuberculosis lesions. Mycobacterium tuberculosis was isolated from these two animals, as well as an animal that did not show tuberculosis pathology. The index case was an adult ewe that was presented for necropsy in a severely weakened condition. The ewe showed advanced miliary tuberculosis with marked macroscopic lesions in the lungs, pleura and respiratory lymph nodes. Limited sampling was done but microscopic tuberculosis lesions were found in almost all the organs sampled, and acid-fast bacilli were generally numerous. Six healthy rams were culled nine months later and a pilot study indicated miliary tuberculosis lesions in one ram, which again were macroscopically most prominent in the lungs, pleura and respiratory lymph nodes. Macroscopic lesions were also noted in the sternal, iliac, prefemoral and retropharyngeal lymph nodes. Microscopy in this animal revealed lesions in the macroscopically affected organs as well as numerous other lymph nodes, and suspected lesions occurred in the testicle and colon. Acid-fast bacilli were scarce to moderate in affected organs. Because of the miliary nature of the lesions in both affected animals, the route of infection could not be established conclusively. The lesions in most affected organs of both animals resembled classical tuberculous granulomas, viz. central caseous necrosis, with various degrees of calcification, surrounded by various numbers macrophages, epithelioid cells, multinucleated giant cells and lymphoplasmacells, and mild to moderate fibrous encapsulation. Necrotic lesions in the spleen, liver and kidney of the ewe were more disseminate and coagulative. A main study conducted on healthy culled animals 19 months after the pilot study failed to find any animal with tuberculosis lesions in the group of 25 sampled. These animals were all negative for mycobacteria via mycobacterial culture. The Interferon-gamma (INFg) assay was performed on all the animals of the pilot and main study but failed to identify the culture-positive animals and showed one false-positive reaction. / Dissertation (MMedVet (Pathology))--University of Pretoria, 2007. / Paraclinical Sciences / unrestricted

>Magister Scientiae - MSc / It is well known, that there is a severe lack of information available pertaining to neutron rich nuclei, specifically of those nuclei with mass numbers ≥ 60. These neutron rich nuclei are not easy to access in current experimental facilities or be produced with sufficient yield to allow for it to be studied. In order to expand our understanding of nuclear physics by studying the properties and characteristics of these nuclei, the development of new facilities producing Radioactive-ion Beams (RIBs) is required. The applications for RIBs are wide, allowing for deeper investigations into the properties of nuclei, their interactions and the manner in which they were formed in the early universe. Additionally, there are various interdisciplinary fields such as medicine, biology and material science in which RIBs can be utilized as a driving mechanism for new research and technological innovation. The iThemba Laboratory for Accelerator Based Sciences (iThemba LABS), South Africa, has proposed a new facility for the production and acceleration of radioactive-ion beams (RIBs). The RIB Project is to be developed in sequential phases and would produce a range of neutron-rich isotopes for low-energy materials science and nuclear physics research. Of specific interest, is the production of the Helium-6 isotope (6He), for its potential applications in various areas of nuclear physics research. The aim of this research work was to design, model and optimise a RIB production target capable of producing high intensity 6He beams, guided by the characteristics of the primary proton beam available for use at iThemba LABS. This research work/design study is however limited, due to the absence of experimentally measured and verified 6He cross section data for proton induced reactions on the proposed target materials (Graphite and Boron Carbide). However, best-estimate approaches were adopted through the use of validated computer codes. Additionally, all 6He yield results are presented as in-target yields, as this study did not cover the diffusion (isotope release) efficiency of the target systems in question. Three RIB production targets types were investigated using Graphite, Boron Carbide and Beryllium Oxide as potential target materials. Following numerous optimisation processes, a Boron Carbide RIB target was converged upon, proving to be suitable for the production of high intensity 6He beams at iThemba LABS, by meeting the material thermal and mechanical limiting criteria for operation. This target system was found to produce an in-target 6He yield rate of 2 ~ 3 x 1011 6He/s, considered sufficient for experimental application at iThemba LABS.

Doctor Educationis / The progressive development of scintillator detectors has made it possible to perform direct electronic lifetime determination up to a few hundred nanoseconds. The 2” by 2” LaBr3:Ce detectors provide a combination of excellent time resolution and good energy resolution. Recently a fast timing array has been commissioned at iThemba LABS, Cape Town consisting of eight 2” by 2” LaBr3:Ce detectors. Test measurements using radioactive sources produced at the laboratory were conducted. Six 2” by 2” LaBr3:Ce detectors were coupled to the AFRODITE array as their first in-beam experiment. AFRODITE consisted of eight HPGe clover detectors as well as two 3.5” x 8” LaBr3:Ce detectors. A particle telescope was used to select the desired reaction channels. The reactions of interest 45Sc(p,d)44Sc and 45Sc(p,α) 42Ca were carried out at a beam energy of 27 MeV. The current analysis also investigates the rare earth nucleus 150Gd which was populated through 150Sm(α,4n)150Gd at a beam energy of 48 MeV. Through these reactions, excited states that have lifetimes which are apt for the characterization of the 2” by 2” LaBr3:Ce detectors were populated. Various techniques such as the slope method and the centroid shift method have been employed to extract the lifetimes of excited states. Lifetimes that were previously measured for 44Sc and 42Ca were measured again in this work. New lifetimes were obtained 44Sc and 150Gd. Shell Model calculation were done to compare experimental and theoretical results. All these endeavours will seek to unveil the quadrupole moment of nuclei and their intrinsic behaviour.