- About
-
The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1 to 10 of 1031 (0.049 seconds)| 1 |
The Role of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein in Viral ReplicationLi, Xuguang January 1996 (has links)
Note:
|
| 2 |
Analysis of seven leukocyte adhesion deficiency (LAD) point mutations in the integrin #beta#2 subunitScarth, Sarah L. January 1999 (has links)
No description available.
|
| 3 |
Immunoregulatory properties of polyclonal immunoglobulin for therapeutic useAlder, Louise B. A. January 1996 (has links)
No description available.
|
| 4 |
Transcriptional activation of human immunodeficiency virus type 1 by NF-κbMatthews, James Robert January 1993 (has links)
This study has analysed some of the mechanisms involved in the transcriptional activation of the human immunodeficiency virus type 1 (HIV-1) by transcriptional modulator proteins of the NF-ĸB/rel family. Initial attempts to purify a single NF-ĸB (p50-p65) heterodimer species from HeLa cells suggested that a family of proteins might contribute to ĸB motif DNA binding activity. HeLa cell ĸB motif DNA binding proteins were shown to be modified by glycosylation. Using circularly permuted DNA probes carrying a KB motif, it was shown that ĸB binding proteins induced significant DNA bending upon binding, while studies of the effects of the poly amine spermidine on purified HeLa cell ĸB motif DNA binding proteins showed it greatly stimulated their DNA binding activity. The DNA binding activity of native ĸB motif DNA binding proteins was also greatly stimulated by the reducing agent dithiothreitol. Using a cDNA encoding the p105 precursor to the NF-ĸB p50 subunit, the wild type DNA binding and dimerisation region (aa35-381) of p50, and three cysteine to serine mutants at cysteine residues (aa62, 119, and 273) conserved throughout the NF-ĸB/rel/dorsal family, were expressed in bacteria. The dissociation constant of the aa62 p50 mutant for the ĸB motif was 10-fold higher than that of the wild type p50. Also, dissociation rate constants for the aa62 mutant-KB motif complex in both the presence and absence of spermidine were anomalously high. The above changes suggested a different DNA binding specificity for the aa62 mutant - this was confirmed by oligonucleotide competition studies. Oligonucleotide protection experiments suggested the presence of a cysteine residue in the p50 DNA binding site-substrate protection experiments showed that this was cysteine 62, and that this residue is involved in redox regulation of p50 DNA binding activity.
|
| 5 |
Study of B lymphocyte subset phenotypes and clinical features of common variable immunodeficiency patients in Hong KongLo, Ching-ha., 盧靜霞. January 2009 (has links)
published_or_final_version / Pathology / Master / Master of Medical Sciences
|
| 6 |
An investigation of susceptibility of alveolar macrophages to HIV 1 infectionAlimohammadi, Azin January 2002 (has links)
No description available.
|
| 7 |
In vitro studies of SIV nef functionKarim, Shamim Akhtar January 2003 (has links)
No description available.
|
| 8 |
The analysis of the in vivo effects of the HIV-1 Nef and Tat regulatory genes using a transgenic mouse systemPennington, Daniel John January 1996 (has links)
No description available.
|
| 9 |
Induction and characterisation of antibody responses in macaques immunised with recombinant SIV antigensBergmeier, Lesley Ann January 2001 (has links)
No description available.
|
| 10 |
An investigation of mutant cell lines deficient in the expression or function of the MHC class II genesQuan, Virginia Anne January 2001 (has links)
No description available.
|
Page generated in 0.0534 seconds