Global ETD Search

41	Effects of anti-DNA antibodies and mycophenolic acid on inflammatory and fibrotic processes in proximal tubular epithelial cells and the implications in the pathogenesis of lupus nephritis Ng, Yee-ching, Claudia. January 2009 (has links) Thesis (Ph. D.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 188-245). Also available in print.
42	Comparison of mycophenolate mofetil and cyclophosphamide on inflammatory and fibrotic processes in the pathogenesis of lupusnephritis: animal and in vitro studies Zhang, Qing, 張清 January 2009 (has links) published_or_final_version / Medicine / Doctoral / Doctor of Philosophy Immunosuppressive agents. Fibrosis. Lupus nephritis - Chemotherapy. Lupus nephritis - Animal models.
43	Effects of anti-DNA antibodies and mycophenolic acid on inflammatory and fibrotic processes in proximal tubular epithelial cells and theimplications in the pathogenesis of lupus nephritis Ng, Yee-ching, Claudia., 吳綺菁. January 2009 (has links) published_or_final_version / Medicine / Doctoral / Doctor of Philosophy DNA antibodies. Immunosuppressive agents. Epithelial cells. Fibrosis. Lupus nephritis - Pathogenesis.
44	The in vivo mechanism of actions of mycophenolate mofetil: insights from murine models of allograft rejection,endotoxemia, ischemia reperfusion injury and lupus nephritis Lui, Sing-leung., 雷聲亮. January 2003 (has links) published_or_final_version / abstract / toc / Medicine / Master / Doctor of Medicine Immunosuppressive agents. Graft rejection. Reperfusion injury. Lupus nephritis.
45	A study of cyclophosphamide on dextran sulfate sodium-induced ulcerative colitis in mice Li, Siu-ming, Ian., 李紹銘. January 2004 (has links) published_or_final_version / Medical Sciences / Master / Master of Medical Sciences Immunosuppressive agents. Ulcerative colitis - Chemotherapy. Mice as laboratory animals.
46	Effects of anti-DNA antibodies on pleural mesothelial cells: in vitro studies to explore thepathogenetic mechanism of pulmonary lupus Guo, Hong, 郭紅 January 2003 (has links) The Best M.Phil Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize, 2001-2003. / published_or_final_version / abstract / toc / Medicine / Master / Master of Philosophy DNA antibodies. Lupus - Genetic aspects. Cytokines. Immunosuppressive agents.
47	The cytotoxic effects of T-2 toxin on normal human lymphocytes. Moodley, Therishnee. January 1998 (has links) T -2 toxin is an immunosuppressive mycotoxin that has been conjoined with several symptoms and diseases as early as the turn of the century, but whose mechanisms of action are still being investigated. Accordingly, this study was an attempt to determine the cytotoxic effects of T -2 toxin on normal human lymphocytes in vitro, with particular emphasis on mitochondrial viability, cellular and nuclear morphology as well as the localisation of the subcellular sites of toxin interaction. The cytotoxicity of T -2 toxin was assessed with the use of a methylthiazol tetrazolium (MTT) assay. This assay targeted the succinate dehydrogenase activity of the lymphocytic mitochondria, over a range of concentrations of T-2 toxin at various incubation times. The morphology of treated lymphocytes was analysed with the use of transmission electron microscopy and the localisation of the toxin was accomplished via immunocytochemistry. DNA fragmentation studies formed an integral part of the analyses. The cytotoxicity assay indicated that not only was cell viability inversely proportional to both the dose and exposure time, but that the eftects of the different doses were only evident at prolonged incubation times (12-24 hours). The electron microscopy studies showed that T-2 toxin (1,56 ug/ml) induced apoptosis (cell suicide) in normal human lymphocytes. This was determined by the observation of chromatin condensation and nuclear disintegration within the toxin treated lymphocytes. Apoptosis seemed to occur independently of mitochondrial damage at 6 hours of exposure to T-2 toxin. The presence of polyribosomes within the treated lymphocytes indicated that protein synthesis was not inhibited. Anti-T-2 toxin conjugated gold label was present in all areas of damage, particularly within the nuclei of the T-2 toxin treated lymphocytes. The DNA fragmentation results showed that T-2 toxin induced fragmentation in lymphocytes, the extent of which was directly proportional to the exposure time. It appears that the early signs of T-2 toxin induced apoptosis in normal human lymphocytes can be determined by damage to the nucleus. / Thesis (M.Med.)-University of Natal, Durban, 1998. T-Lymphocytes. Mycotoxins. Immunosuppressive agents. Toxins. Theses--Medicine.
48	An in vitro investigation of the anti-inflammatory and immunosuppressive effects of the synthetic contraceptives medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A) / Kriek, W. J. January 2005 (has links) Thesis (MScMed)--University of Stellenbosch, 2005. / Bibliography. Also available via the Internet.
49	Posttransplantation bone disease : the effect of immunosuppressive drugs on bone: clinical and experimental studies / Abdelhadi, Mohamed Mohamed, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 5 uppsatser.
50	The immunosuppressive effects of Triptolide and Rapamycin on mouse model of cardiac transplantation Liu, Yan, January 2007 (has links) Thesis (Ph. D.)--University of Hong Kong, 2008.

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