Lateral diffusion of membrane components (lipids and proteins) is an important membrane property to measure since the essential process of absorption of anti-cancer and other drugs -some of which are not soluble in lipids and therefore would not be able to penetrate the cell membrane through passive diffusion- lies on it. In particular, the procedure of diffusion into the cell cytoplasm is reliant on free volumes in the membrane (passive diffusion) as well as carrier proteins (facilitated diffusion). By enhancing the mobility of lipids and/or proteins, the possibility of the carrier protein to "encapsulate" pharmacological components maxim- izes, as a "scanning" of the proteins gets performed due to the fluid phase of a biological membrane. At the same time, the increased mobility of the lipids facilitates the passage of lipid-soluble molecules into the cell. Thus, given that the success of anticancer treatments heavily depends on their absorption by the cell, a significant enhancement of the cell mem- brane permeability (permeabilisation) is rendered vital to the applicability of the technique. For this reason, there is augmented interest in combined methods such as Nanotechnology based drug delivery that is focused on the development of optimally designed therapeutic agents along with the application of shock waves to enhance the membrane permeability to the agents. This study examines the impact of shock waves on a numerical model of a biological membrane. Cont/d.

A direction of arrival (DoA) estimation technique for broadband microwave signals is proposed using a single ultrawideband antenna. It is inspired by the sound source localization ability of a human auditory system using just one ear (monaural localization). By exploiting the incident angle-dependent frequency response of a wideband antenna, the DoA of a broadband microwave signal can be estimated. The DoA estimation accuracies are evaluated for two antenna configurations and microwave signals with different signal-to-noise ratios. Encouraging the DoA estimation performance of the proposed technique is demonstrated in both simulation and experiment.

Lateral diffusion of membrane components (lipids and proteins) is an important membrane property to measure since the essential process of absorption of anti-cancer and other drugs -some of which are not soluble in lipids and therefore would not be able to penetrate the cell membrane through passive diffusion- lies on it. In particular, the procedure of diffusion into the cell cytoplasm is reliant on free volumes in the membrane (passive diffusion) as well as carrier proteins (facilitated diffusion). By enhancing the mobility of lipids and/or proteins, the possibility of the carrier protein to "encapsulate" pharmacological components maxim- izes, as a "scanning" of the proteins gets performed due to the fluid phase of a biological membrane. At the same time, the increased mobility of the lipids facilitates the passage of lipid-soluble molecules into the cell. Thus, given that the success of anticancer treatments heavily depends on their absorption by the cell, a significant enhancement of the cell mem- brane permeability (permeabilisation) is rendered vital to the applicability of the technique. For this reason, there is augmented interest in combined methods such as Nanotechnology based drug delivery that is focused on the development of optimally designed therapeutic agents along with the application of shock waves to enhance the membrane permeability to the agents. This study examines the impact of shock waves on a numerical model of a biological membrane. Cont/d.

Laser spot welding on a stainless steel plate was investigated numerically and experimentally. A numerical method was applied to predict the dimensions of fusion zone and temperature distribution in the welding process. In the numerical approach, a three-dimensional heat source equation is used to model laser beam intensity distribution, which is assumed to be a Gaussian distribution in the radial direction and exponential decay in the penetration direction. The parameters of the pulsed Nd:YAG laser spot welding include pulse energy, pulse duration, and incident angles of laser beam. Experiments were also conducted in the study. The characteristic lengths of welded spot were measured by metallographic method, and then, the dynamical behavior of the laser welding process was visualized by a high-speed video camera. Finally, the temperature variations during the laser-spot welding process were measured by an infrared pyrometer system. It is demonstrated that the numerical results by proposed model agree well with experimental observations in predicting the characteristic lengths of welded spots. From this study, it is found that weld dimensions is a strong function of incident angles of laser beam, laser energy, and pulse duration time.