published_or_final_version / Microbiology / Doctoral / Doctor of Philosophy

Texte remanié de: Th.--Démographie--Louvain. / Bibliogr. p. 229-244.

M.Tech. / Infantile colic typically occurs in 10-30% of infants between the ages of two weeks and sixteen weeks (Savino, 2007) and may be defined according to “Wessel’s rule of threes” which states that a diagnosis may be made when a healthy baby with no underlying disease cries for more than 3 hours a day on more than 3 days a week for a period of 3 weeks (Zwart et al., 2007). Infantile colic usually begins at two weeks of age and increases in intensity at about six weeks until around sixteen weeks where it usually resolves spontaneously (Cox & Roos, 2008). Its cause is not exactly known but a number of theories are suggestive of causes that may play a role in its development (Pauli-Pott et al., 2000), namely gastrointestinal disorders and allergies, neurological disorders, a stressful parent environment, low birth weight, maternal smoking and diet. Research has shown that the stress from colicky infants can damage early interaction of a family (Raiha et al., 2002). Studies have shown that conventional medication may prove efficacious in the treatment of infantile colic, however, a high rate of side effects are evident (Underwood, 2009). The aim of this study was to determine the effect of Magen®, a homeopathic complex on the treatment of Infantile Colic by means of an Infant Colic Questionnaire for infant and caregiver as well as a daily monitoring diary to record the amount and duration of infant crying on a daily basis. The study was approved and passed by the University of Johannesburg’s Faculty of Health Sciences Academic Ethics Committee (AEC45/02-2010) and the Higher Degrees Committee (HDC45/02-2010) on the 26th of May 2010. There were thirty participants recruited to participate in the study. The thirty participants consisted of both males and females between the ages of two weeks and ten weeks. Of the thirty participants recruited, one was recruited from the Karien Camphor Nursing Practice in Pretoria and the remaining twenty nine were recruited from the Stork’s Nest at Netcare Femina Hospital in Pretoria. Infants had to comply with Wessel’s criteria (infant that cries for more than 3 hours a day on more than 3 days a week for a period of 3 weeks). Infants already diagnosed with an underlying condition other than colic, such as gastroeosophageal reflux disease, any infection or cardiac disease were excluded from the study. The study was a randomised, double-blind placebo controlled study of six days in duration for each participant.

Dissertation (D.P.H.)--University of Michigan.

Dissertation (D.P.H.)--University of Michigan.

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No description available.

Vigabatrin (VGB) is an anti-epileptic drug used to treat children with Infantile Spasms (IS). The 3.0 flicker amplitude of the electroretinogram (ERG) is currently used to monitor visual function changes in infants on VGB. To find a more specific marker of permanent changes due to VGB, sedated ERGs were performed on 31 IS patients and 13 retinally normal controls to isolate components of the cone pathway. ERG growth curves, for each component, recorded from children with IS were generated using data recorded pre-VGB treatment and for controls. Only the cone off response (from Off bipolar cells) and cone photoreceptor sensitivity were associated with decreased flicker amplitude. Twenty nine percent of patients had an abnormal cone off response. No patient had an abnormal cone off response at baseline. No patient with an abnormal cone off response recovered normal function. The cone off response could serve as a marker VGB retinal toxicity.

Vigabatrin (VGB) is an anti-epileptic drug used to treat children with Infantile Spasms (IS). The 3.0 flicker amplitude of the electroretinogram (ERG) is currently used to monitor visual function changes in infants on VGB. To find a more specific marker of permanent changes due to VGB, sedated ERGs were performed on 31 IS patients and 13 retinally normal controls to isolate components of the cone pathway. ERG growth curves, for each component, recorded from children with IS were generated using data recorded pre-VGB treatment and for controls. Only the cone off response (from Off bipolar cells) and cone photoreceptor sensitivity were associated with decreased flicker amplitude. Twenty nine percent of patients had an abnormal cone off response. No patient had an abnormal cone off response at baseline. No patient with an abnormal cone off response recovered normal function. The cone off response could serve as a marker VGB retinal toxicity.

Mémoire d'orthophonie : Médecine : Université de Nantes : 2007. / Bibliogr.