Indiana University-Purdue University Indianapolis (IUPUI) / An important topic in autonomous vehicle related research in recent times is road departure warning (RDW) and road keeping assistance (RKA). RDW or RKA should be able to recognize and avoid roadside objects. Standard tests are needed to evaluate the performance of RDW and RKA feature of cars from different manufacturers. To avoid damage to the cars under test and the test environment during testing, there is a need of soft, durable and reusable surrogate targets representing various real roadside objects such as curb, concrete divider and metal guardrail. These surrogate objects should have representative characteristics of real roadside objects from the point of view of various commonly used object detection sensors on the vehicles such as camera, radar and LIDAR. Transportation Active Safety Institute (TASI) at Indian University-Purdue University Indianapolis (IUPUI) is in the process of developing surrogate concrete divider, curb metal guardrail and grass that should be recognized as real roadside objects by LIDAR sensors, can be crashed without damage to the test vehicle and can be reused even after multiple crashes. The first step is to understand what the representative roadside objects should look like from the point of view of LIDAR units using laser of various wavelengths, and the next step is to design surrogate objects that successfully emulate the properties of the real roadside objects. Reflectance of an object is an important property for LIDAR detection. This thesis describes an approach for the determination of infrared reflectance property of concrete, metal guardrail and grass for different LIDAR view angles. Various samples of each of these roadside objects were evaluated. Based on these measurements, the suggested reflectance of surrogate roadside objects in the common LIDAR wavelength range of 800-1100 nm is specified. Finally, the design of surrogate roadside objects that satisfy these requirements is described, and the infrared reflectance of these surrogate objects are compared to the suggested reflectance bounds for different LIDAR view angles.

Over the last several years questions about the strength of structural lumber have been raised. The purpose of this study was to examine the relationship between physically measured wood properties using Near Infrared spectroscopy. Physical properties were determined from (2 x 4 x 2 in.) cut samples. Destructive mechanical testing was performed on 744; 8 feet long, No.2 grade 2x4’s. Diffuse reflectance NIR spectra was collected from the cross-sectional face of each block using FOSS NIR Systems Inc. Model 5000 scanning spectrometer. Calibrations were then created between measured properties and NIR estimates. Density, specific gravity, latewood percentage, MOE and MOR had coefficient of determinations of 0.78, 0.56, 0.02, 0.56, and 0.48 respectively. The low correlation is likely caused by the grade of lumber. Because No.2 lumber has considerable knots, they were the determining factor in strength and stiffness; these results would likely not be similar in a higher grade lumber.

Hubble Space Telescope images of the Orion nebula taken with the Wide-Field Camera have revealed subarcsecond structure in several dozen objects which are apparently ionized externally from nearby stars. We have obtained near-IR images and IR polarimetry of the Orion region to search for correlations with the WFC objects. We find that all of the ultracompact WFC objects are associated with IR features of some sort, and that some are associated with strongly polarized IR emission. The object with strongest polarization also shows small IR "lobes". In addition, we find some previously unreported sources, showing polarized IR emission, outside the field of the HST images, which we believe may be the same sorts of object. We note that the object with strongest polarization has a double-lobed appearance in the K band image.

Providing molecular fingerprint information, vibrational spectroscopy is a powerful tool for chemical analysis. In the mid-infrared window, FT-IR spectroscopy and microscopy have been routinely used for sample characterization. In the near-IR window, near-infrared spectroscopy has been widely used for tissue analysis and for the detection of lipids in the arterial walls. Yet, these traditional linear spectroscopies have intrinsic limitations. FT-IR spectroscopy suffers from a poor spatial resolution and strong water absorption for the study of living systems. Near-infrared spectroscopy avoids water absorption, yet it suffers from a poor, millimeter-scale spatial resolution in tissue analysis. My thesis focuses on breaking these limitations through photoacoustic and photothermal detection approaches. The first part of my thesis is on improving the spatial resolution in catheter-based intravascular photoacoustic (IVPA) imaging. By near-infrared excitation of lipids and acoustic detection, IVPA allows depth-resolved identification of lipid-laden atherosclerotic plaque. Thus far, most IVPA endoscopes use multimode fibers, which do not allow tight focusing of photons. Recent experiments on pulse propagation in multimode graded-index fibers have shown a nonlinear improvement in beam quality. Here, we harness this nonlinear phenomenon for the fiber-delivery of nanosecond laser pulses. We built a photoacoustic catheter 1.4 mm outer diameter, offering a lateral resolution as fine as 30 μm within a depth range of 2.5 mm. Such resolution is one order of magnitude better than current multi-mode fiber-based intravascular photoacoustic catheters. At the same time, the delivered pulse energy can reach as high as 20 μJ, which is two orders of magnitude higher than that of an optical resolution photoacoustic endoscope built with single-mode fiber. These improvements are expected to promote the biomedical application of photoacoustic endoscopes which require both high resolution and high pulse energy. Based on the technical advances, my thesis work further demonstrated longitudinal imaging of the same plaque in the same living animal. Recently developed mid-infrared photothermal (MIP) microscopy overcomes the limitations in FT-IR microscopy by probing the IR absorption-induced photothermal effect using visible light. MIP microscopy yields sub-micrometer spatial resolution with high spectral fidelity and much-reduced water background. The second part of my thesis work pushes the physical limits of MIP microscopy in aspects of detection sensitivity and imaging speed using two approaches. First, taking advantage of the interference scattering effect, the scattering signal from the sample can be greatly enhanced. Together with the relatively large infrared absorption coefficient, the sensitivity of the infrared spectrum is greatly improved, and single virus detection is achieved. Second, by using fluorescence as a thermo-sensitive probe, the temperature raise by infrared absorption can be retrieved in a more efficient way and much higher imaging speed and sensitivity are thus accomplished.

Abstract Background: The discovery of brown adipose tissue (BAT) in adults has sparked interest in its role as a therapeutic target in metabolic disorders. Preliminary studies have indicated that infrared thermography may be a promising way to quantify this thermogenic organ, which in humans is located primarily in the supraclavicular area and is activated by cold. However, ways to standardize infrared thermography methodology and to ensure measurements are reproducible have not been established. Objective: This study aims to establish a standardized and reproducible protocol to measure a thermal response to cold in the supraclavicular area. Method: In phase 1 of the study, thermal images of the supraclavicular area were taken on 3 occasions in 28 healthy adult males with mean age 23.95 ±5.87 years and mean BMI 25.20 ±3.93 kg/m2 who demonstrated a 100kcal/d increase in energy expenditure when exposed to 12ºC; a temperature known to increase BAT activity without shivering. During the first and second visits, participants were acclimated for 1 hour at 32ºC and room temperature (20-23ºC) respectively, followed by a 1 hour period of torso cold exposure at 12ºC using a cooling blanket. The third visit consisted of taking thermal images at room temperature over two hours. Body composition was measured with DEXA scanner. In phase 2, 3 trials of 32ºC acclimation followed by 12ºC cold exposure (32ºC-cold) were studied in 14 healthy adult males (mean age 20.93 ±2.4 years and mean BMI 23.55 ±3.15 kg/m2) for repeatability. The outdoor temperature on the morning of each visit was recorded from the website http://climate.weather.gc.ca in both phases. Results: In phase 1 the supraclavicular temperature stabilized after 45 minutes of acclimation at 32ºC and then rose abruptly with cooling, plateauing at 10 minutes. The change in supraclavicular temperature in response to cooling was greater after 32ºC compared to room temperature acclimation (0.22 ±0.19 vs 0.13±0.17ºC, p=0.053). There was no relation between outdoor temperature on the morning of the visit and the 32°C-cold thermal response (r=-0.18, p=0.14). The 32ºC-cold thermal response did not correlate with cervical and supraclavicular fat in 25 young males with BMI between 19.3-32.3 kg/m2 (r=-0.26, p=0.21). In phase 2, the thermal response after 32ºC acclimation was reproducible [intraclass correlation coefficient of 0.69 (0.14-0.72)]. Conclusion: Acclimation at 32ºC produces a greater and earlier response to cold in the supraclavicular area than room temperature acclimation. The thermal response after 32ºC acclimation is reproducible and unlikely to be affected by outdoor temperature and subcutaneous fat in the neck. These data suggest that the use of infrared thermography using the 32ºC-cold protocol may be effective for detecting the metabolic activity of brown adipose tissue. / Thesis / Master of Science (MSc)

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