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The association of uric acid and plasminogen activator inhibitor-1 (PAI-1) with cardiovascular function in South African women : the POWIRS-study / I.M. PalmerPalmer, Iolanthe Marike January 2006 (has links)
Motivation: Hypertension is a fast growing health risk, leading to increased incidences of
cardiovascular dysfunction and mortality. However, the prevalence of hypertension is higher
in some ethnic populations than others. Several South African studies have found that the
African population is more susceptible to the development of hypertension, compared to the
Caucasian population. Cardiovascular dysfunction is often accompanied by elevated levels
of uric acid (UA) and plasminogen activator inhibitor-I (PAI-1) and both are factors
associated with the metabolic syndrome. A lack of data regarding the association of UA and
PAL1 with cardiovascular dysfunction in a South African context, serves as a motivation for
conducting this study.
Objective: To determine the association of UA and PAI-1 with cardiovascular dysfunction in
African and Caucasian women from South Africa.
Methodology: The manuscript presented in Chapter 2 made use of the data obtained in the
POWIRS (Profiles of Obese Women with the Insulin Resistance Syndrome) study. A group
of 102 African women and 115 Caucasian women, living in the North West Province of
South Africa, were recruited according to their body mass indexes. The groups were divided
into lean, overweight and obese according to their body mass index. Anthropometric and
cardiovascular measurements were taken and determinations were done of their blood lipid
profiles, UA. PAI-1, fasting insulin and glucose levels, HOMA-IR (homeostasis model
assessment-insulin resistance) and leptin levels. The subject's total dietary protein intake
was determined by means of a dietary questionnaire. Comparisons between the groups
were done using an independent t-test as well as a multiple analysis of covariance
(MANCOVA) whilst adjusting for certain variables. Each ethnic group was divided into UA
and PAI-1 tertiles, for comparison between the 1" and 3' tertiles. Correlation ~0efIi~ientS
were determined to show any associations between UA and PAI-1 with cardiovascular
variables as well as variables associated with the metabolic syndrome. Forward stepwise
multiple regression analyses were performed using UA and PAL1 respectively as dependent
variables.
The study was approved by the Ethics committee of the North-West University and all the
subjects gave informed consent in writing. The reader is referred to the experimental
procedure section in Chapter 2 for a more detailed description of the subjects, study
design and analytical procedures used in this dissertation.
Results and conclusion: Results from the POWIRS-study showed that despite the
African women's higher blood pressure, they had significantly lower levels of UA and PAI-I
compared to the Caucasian women. Although the Caucasian women had significantly
higher circulating levels of UA and PAI-1, they showed no sign of cardiovascular
dysfunction. The detrimental effects might, however, become more noticeable with an
increase in age. From this study it is concluded that UA and PAL1 is not associated with
the increased blood pressure in young African women. / Thesis (M.Sc. (Physiology))--North-West University, Potchefstroom Campus, 2006.
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The association of uric acid and plasminogen activator inhibitor-1 (PAI-1) with cardiovascular function in South African women : the POWIRS-study / I.M. PalmerPalmer, Iolanthe Marike January 2006 (has links)
Motivation: Hypertension is a fast growing health risk, leading to increased incidences of
cardiovascular dysfunction and mortality. However, the prevalence of hypertension is higher
in some ethnic populations than others. Several South African studies have found that the
African population is more susceptible to the development of hypertension, compared to the
Caucasian population. Cardiovascular dysfunction is often accompanied by elevated levels
of uric acid (UA) and plasminogen activator inhibitor-I (PAI-1) and both are factors
associated with the metabolic syndrome. A lack of data regarding the association of UA and
PAL1 with cardiovascular dysfunction in a South African context, serves as a motivation for
conducting this study.
Objective: To determine the association of UA and PAI-1 with cardiovascular dysfunction in
African and Caucasian women from South Africa.
Methodology: The manuscript presented in Chapter 2 made use of the data obtained in the
POWIRS (Profiles of Obese Women with the Insulin Resistance Syndrome) study. A group
of 102 African women and 115 Caucasian women, living in the North West Province of
South Africa, were recruited according to their body mass indexes. The groups were divided
into lean, overweight and obese according to their body mass index. Anthropometric and
cardiovascular measurements were taken and determinations were done of their blood lipid
profiles, UA. PAI-1, fasting insulin and glucose levels, HOMA-IR (homeostasis model
assessment-insulin resistance) and leptin levels. The subject's total dietary protein intake
was determined by means of a dietary questionnaire. Comparisons between the groups
were done using an independent t-test as well as a multiple analysis of covariance
(MANCOVA) whilst adjusting for certain variables. Each ethnic group was divided into UA
and PAI-1 tertiles, for comparison between the 1" and 3' tertiles. Correlation ~0efIi~ientS
were determined to show any associations between UA and PAI-1 with cardiovascular
variables as well as variables associated with the metabolic syndrome. Forward stepwise
multiple regression analyses were performed using UA and PAL1 respectively as dependent
variables.
The study was approved by the Ethics committee of the North-West University and all the
subjects gave informed consent in writing. The reader is referred to the experimental
procedure section in Chapter 2 for a more detailed description of the subjects, study
design and analytical procedures used in this dissertation.
Results and conclusion: Results from the POWIRS-study showed that despite the
African women's higher blood pressure, they had significantly lower levels of UA and PAI-I
compared to the Caucasian women. Although the Caucasian women had significantly
higher circulating levels of UA and PAI-1, they showed no sign of cardiovascular
dysfunction. The detrimental effects might, however, become more noticeable with an
increase in age. From this study it is concluded that UA and PAL1 is not associated with
the increased blood pressure in young African women. / Thesis (M.Sc. (Physiology))--North-West University, Potchefstroom Campus, 2006.
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Plasminogen activator inhibitor type-1 : structure-function studies and its use as a reference for intramolecular distance measurements /Hägglöf, Peter, January 2003 (has links)
Diss. (sammanfattning) Umeå : Univ., 2004. / Härtill 4 uppsatser.
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Ozone and lung fibrosisKatre, Ashwini A. January 2009 (has links) (PDF)
Thesis (M.S.P.H.)--University of Alabama at Birmingham, 2009. / Title from PDF title page (viewed on Sept. 3, 2009). Includes bibliographical references (p. 43-48).
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Relative hypercoagulation induced by suppressed fibrinolysis after tisagenlecleucel infusion in malignant lymphoma / 悪性リンパ腫に対するチサゲンレクルユーセル投与後に見られる線溶抑制および相対的凝固亢進状態Yamasaki(Morita), Makiko 24 November 2022 (has links)
京都大学 / 新制・課程博士 / 博士(人間健康科学) / 甲第24292号 / 人健博第107号 / 新制||人健||8(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 藤井 康友, 教授 岡 昌吾, 教授 滝田 順子 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DFAM
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THE ROLE OF THE PROTEIN PHOSPHATASE 1 INHIBITOR-1 IN REGULATION OF MURINE CARDIAC PHYSIOLOGY AND PROGRESSION OF CARDIOMYOPATHYPATHAK, ANAND 03 April 2006 (has links)
No description available.
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The Role of Inhibitor-1 and Heat Shock Protein 20 in Cardiac PathophysiologyNicolaou, Persoulla January 2008 (has links)
No description available.
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In vivo- und in vitro-Funktionsanalysen von Bax Inhibitor-1 bei humanen Karzinomzellen / In vivo and in vitro functional analysis of Bax Inhibitor-1 in human carcinoma cellsKang, Tae-Won 03 May 2007 (has links)
No description available.
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Kardiale Phänotypisierung einer transgenen Mauslinie mit herzspezifischer Calcium-Calmodulin-Kinase IIδc- Überexpression auf einem Phosphatase-Inhibitor-1- Knockout-Hintergrund / Cardiac phenotyping of a transgenic mouse model with cardiac specific Ca2+/calmodulin-dependent protein kinase IIδc overexpression on a phosphatase inhibitor -1 knockout backgroundBrammen, Christina Andrea Anna 29 September 2015 (has links)
No description available.
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Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer : Roles for the α7nAChRNovotny, Ann January 2009 (has links)
No description available.
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