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Class of 2009 Abstract / OBJECTIVES: The purpose of this study was to examine solutions of midazolam at a concentration of 1 mg/ml in 2 different types of IV bags while being stored under different conditions to see if they maintain stability over a one month period. METHODS: Triplicate solutions of midazolam 1 mg/ml were made in polyolefin and polyvinyl chloride IV bags and stored under refrigeration, exposed to light at room temperature, and protected from light in amber bags at room temperature. High performance liquid chromatography was used to evaluate solution stability over a 4 week period. RESULTS: All solutions remained stable with no statistically significant (p = 0.164) change in concentration from initial over the four week period. Storage condition also did not have an impact on stability and neither did type of plasticizer used. CONCLUSIONS: Solutions remain stable for longer than the manufacturer stated 24 hours and may be made in advance and stored for future use.

ABSTRACT Purpose The study was conducted to compare intralesional methylprednisolone acetate 40 mg/ml (Depo-Medrol) injection with incision and curettage in the treatment of chalazia. Method A prospective, interventional clinical study was conducted. Seventy-seven patients that met the inclusion criteria and gave informed consent were randomized to receive either intralesional methylprednisolone injection or incision and curettage. Patients were followed up at two weeks and at one month, and the treatment was repeated when indicated. Results Seventy-three patients completed the study. At two weeks, after one treatment, there was a significant difference in outcome (p = 0.002) between the two groups: 10 (27%) chalazia resolved after intralesional methylprednisolone injection and 23 (64%) after incision and curettage. At one month however, there was no statistical difference (p = 0.223) in outcome between the two groups: resolution occurred in 24 patients (65%) after intralesional methylprednisolone injection, and in 28 patients (78%) after incision and curettage. In cases that were successfully treated at one month, 58% required a second treatment with intralesional injection, which was significantly more (p = 0.020) than the 18% with incision and curettage. In both groups, the initial chalazion size and duration did not significantly influence the outcome of treatment. The average time to perform intralesional injection (39 seconds) was significantly quicker (p = 0.000) than the average time for incision and curettage (2 minutes 46 seconds). In 3 out of 37 injected patients, a slight subcutaneous methylprednisolone deposit was visible at one month. Conclusion Incision and curettage remains the gold standard in the treatment of chalazia, but intralesional methylprednisolone (Depo-Medrol) injection is an useful alternative treatment modality.

Thesis (M.S.)--Ohio State University, 2008. / Title from first page of PDF file. Includes bibliographical references (p. 16-18).

Thesis (M.S.)--University of Michigan, 1935. / Also issued in print.

Thesis (M.S.)--University of Michigan, 1935. / eContent provider-neutral record in process. Description based on print version record.

Colored photographs included. / Thesis (M.Sc.D.)--Boston University. Henry M. Goldman School of Graduate Dentistry, 1983 (Endodontics) / Bibliography: leaves 59-63. / Profound anesthesia is of paramount importance to the endodontist when treating vital cases. Many a clinician has experienced the frustration of attempting root canal therapy upon an inadequately-anesthetized “hot” mandibular tooth. Consequently, many different methods of anesthetizing lower teeth have been proposed, including; 1. Mandibular block with a lingual supplementary injection as described by Schilder[1] 2. Periodontal ligament injection devices[2,3,4] 3. Gow Gates[5-9] 4. Akinosi[10] 5. Intraosseous[11] 6. Interseptal[12] This project　studied the efficacy of the first　two methods in delivering mandibular anesthesia for endodontic purposes.　Its main objective was　to answer the question of whether an instrument such as the Ligmaject[tm] is a beneficial　addition　to　the endodontic armamentarium. Questionaires were completed by graduate endodontic students at B.U.S.G.D. 50 teeth were anesthetized using a mandibular block and lingual　supplemental injection. 63 teeth were anesthetized using the Ligmaject[tm]. Results demonstrated that the Ligmaject[tm]; 1.　Yielded faster onset　of anesthesia. 2. Provided shorter duration of anesthesia (30 min. to one hour) than the mandibular block (2-4 hours). 3. Was generally more comfortable for patients than the mandibular block.　However, the PDL-injection was extremely painful for some patients. 4. Was　less reliable　than　the mandibular block and lingual　supplemental in rendering vital mandibular teeth　totally numb. A large number Of PDL-injected teeth needed mandibular blocks in order to obtain access for the intrapulpal injections. This required additional manipulations of the patients. 5. Should not be used on undebrided areas or teeth with suppurative periodontal 1esions. 6. Has the potential for initiating periodontal damage even on healthy periodontiums as demonstrated by a case report　documented with preoperative and postoperative radiographs and photos. Preservation of the attachment　apparatus is a critical element　of any dental　discipline. Despite its advantage of shorter anesthetic duration, the use of the Ligmaject[tm] does not　seem consistent with this philosophy.

Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2006. / Härtill 4 uppsatser.