Thesis (Ph. D.)--University of Wisconsin--Madison, 1980. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 397-405).

Thesis (M.Ed.)--Regis University, Denver, Colo., 2006. / Title from PDF title page (viewed on Sept. 14, 2006). Includes bibliographical references.

Thesis (M.Ed.)--Regis University, Denver, Colo., 2006. / Title from PDF title page (viewed on Nov. 20, 2006). Includes bibliographical references.

Deliberative democracy and conflict management models have been given increasing attention for their potential consistency and similarities, which is useful knowledge given the opened possibilities of interdisciplinary work. I argue that this debate ought to be broadened to include how conflict transformation and a pragmatic strand of deliberative democracy are aligned with regard to orientation to conflict. First, I offer an account of why conflict transformation’s key values should be seen as valuable for democratic theory to emulate. Second, I show how a pragmatic strand of deliberative democracy is consistent and similar with respect to those key values. Together, these build a framework which offers the ability for practitioners and theorists to pursue interdisciplinary work between two particular strands of deliberative democracy and conflict management which to date have not been given adequate attention.

No description available.

Pas de résumé en français / Primary central nervous system lymphomas (PCNSL) are very aggressive malignancies with poor survival rate even with treatments (survival median is 44 months). This disease affects immune cells (lymphocytes) and forms diffuse and non-surgically removable tumor in the central nervous system. High-dose chemotherapy and radiotherapy are the common treatments with severe side effects. New therapeutic approaches are required for increasing treatment efficiency. We focused on primary intraocular lymphomas (PIOL) and primary cerebral lymphomas (PCL), which are subtypes of PCNSL. PIOL and PCL cells have a high propensity to migrate and form metastases in the brain and in the controlateral eye in the case of PIOL, and in the eye in the PCL case. However, metastatic dissemation mechanisms remain unclear. The objective of the present work was to study the effects of innovative treatments of B-cell lymphoma on primary tumor, on metastases, and on circulating tumor cells in PIOL and PCL immunocompetent syngeneic murine models of lymphomas using non-invasive in vivo imaging methods. We studied the effects of Ublituximab, a glycoengineered anti-CD20 monoclonal antibody (mAb), and CpG-ODN, a TLR-9 agonist, in mouse models. We showed that Ublituximab exhibits significant anti-tumor effect in PIOL and PCL, while CpG showed significant anti-tumor effect in PCL. We monitored the tumor burden and metastases using innovating non-invasive optical imaging or cell detection methods: bioluminescence imaging (BLI) and in vivo flow cytometer (IVFC). BLI was used to locate metastasis and to quantify tumor burden. We indeed developed a bioluminescence-based tumor burden quantification method that reduces user-dependence, allows comparisons between experiments, reveals statistical relevance, and which is easy to use. An IVFC device was set up to investigate the role of circulating tumor cells (CTCs) in PIOL and PCL. This fluorescence-based technique allows detection of CTCs by analyzing the cells flowing in blood vessels. However we had to overcome the problem of autofluorescence and tissue absorption. Two approaches were studied in parallel: a elaborating new cell line expressing far red fluorescent proteins, modulating the excitation light of an IVFC device to give the cell a unique signature therefore enhancing sensitivity, increasing signal to noise ratio. The modulated excitation IVFC allowed us to calculate the velocity of cells, and infer their position in blood vessel phantoms. The analysis of treatment effects on tumor burden, metastases and CTCs in PIOL and PCL could help understanding lymphoma metastatic dissemination and contribute to treatment follow-up, thus allowing design of new therapeutic approaches with increased efficacy.

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Interdisciplinary Science, 1982. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE / Includes bibliographical references. / by Paul Curtis Watkins. / M.S.

Through investigating my installation, performance, video and collaborative practice, Honeymoons builds connections between timelessness in repetition, the sacred potentials of pop culture, the animation of matter and the relationship of the body to space. Central to these relationships are questions about the function of the erotic in a mediated world. How can a sensual experience help us to define what is real, what has value?

Indiana University-Purdue University Indianapolis (IUPUI) / Hospital costs are the largest contributor to US health expenditures, making them a common target for cost containment policies. Policies that reduce fragmentation in health care and related systems could increase the value of these expenditures while improving outcomes. Efforts to address fragmentation of health care services, such as Accountable Care Organizations, have typically been enacted at the scale of health systems. However, coordination within health care facilities should also be explored. In three essays, I analyze the role of coordination in several forms. First, I examine the introduction of interdisciplinary care teams within a hospital. This analysis features care coordination within a health care facility with the potential to reduce resource utilization through improved communication between team members and between patients and their care providers. I find that care coordination reduced length of stay for some patients while maintaining care quality. This combination results in higher value care for patients and hospitals. Second, I explore whether these interdisciplinary care teams impact resource utilization and patient flow throughout the hospital. The primary outcome is reduction in patient transfers to the ICU. Here, care coordination includes interdisciplinary teams as well as coordination between interdisciplinary teams and intensivists in ICUs. Findings from this analysis suggest that ICU transfers were unaffected by care coordination. Finally, I examine coordination on a larger scale. I leverage data from a national database of trauma patients to compare mortality among adolescent patients with isolated traumatic brain injury between adult trauma centers and pediatric trauma centers. Previous work has shown that younger pediatric patients with this injury benefit from treatment at pediatric trauma centers. However, it is unclear whether this benefit extends to older pediatric patients on the cusp of adulthood. I find that, after adjusting for differences in injury severity, adolescent patients have no difference in mortality risk when treated at adult or pediatric trauma centers. This finding supports the current regionalized model of trauma care where severely injured patients are taken to the nearest trauma center, regardless of designation as pediatric or adult. / 2023-07-01

No description available.