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IFN-α and β restrict JC virus replication in primary human fetal glial cells : implications for progressive multifocal leukoencephalopathy therapy / IFN-alpha and beta restrict JC virus replication in primary human fetal glial cellsCo, Juliene Kimberly G January 2006 (has links)
Thesis (M.S.)--University of Hawaii at Manoa, 2006. / Includes bibliographical references (leaves 62-69). / viii, 69 leaves, bound ill. 29 cm
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Induktion verschiedener Aktivitätsmuster über differentielle Rezeptor-Rekrutierung von Typ I IFNJaks, Eva Unknown Date (has links)
Univ., Diss., 2006--Frankfurt (Main)
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Efficacy and immunological mechanisms of type 1 interferon gene therapy in murine cytomegalovirus /Bartlett, Emmalene J. January 2002 (has links)
Thesis (Ph.D.)--Murdoch University, 2002. / Thesis submitted to the Division of Health Sciences. Bibliography: leaves 210-245.
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Untersuchungen zur Struktur und Dynamik des Typ-I-Interferon-RezeptorsStrunk, Jennifer Julia. Unknown Date (has links) (PDF)
Frankfurt (Main), Universiẗat, Diss., 2008.
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Interferon, virus vaccines and antiviral drugs /Rodrigues, Ana Mara Lopes. January 2007 (has links)
Thesis (Ph.D.) - University of St Andrews, December 2007.
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Genetic polymorphisms of type I interferon receptor 1 affect the susceptibility to chronic HBV infection association analysis and mechanistic investigation /Zhou, Jie, January 2007 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.
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Interferon kinetics and its effect on DNA vaccine induced immunity in channel catfish (Ictalurus punctatus)Harder, Kendal Thomas, Nusbaum, Kenneth E., January 2008 (has links) (PDF)
Thesis (M.S.)--Auburn University, 2008. / Abstract. Vita. Includes bibliographical references (p. 81-91).
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The role of innate immunity in protection against respiratory syncytial virus (RSV)Vaghefi, Negin Gitiban. January 2006 (has links)
Thesis (Ph. D.)--Ohio State University, 2006. / Available online via OhioLINK's ETD Center; full text release delayed at author's request until 2007 Mar 10
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Cell biology of interferon inducible GTPasesMartens, Sascha. Unknown Date (has links) (PDF)
University, Diss., 2004--Köln.
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Avaliação da concentração de Interferon-gama em pacientes com Tuberculose pulmonar e contatos diretos, por Quantiferon TB Gold (In tube method)Santana Filho, Eduardo Bentes 17 May 2012 (has links)
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Previous issue date: 2012-05-17 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis complex species, which infect the exposed individuals, initiate an immune response with production of several cytokines, among them interferon-gamma (IFN-gamma), which is crucial for activation of cellular immune response against TB bacillus. This cytokine has been extensively studied as a possible biomarker for diagnosis of TB. In this work, we analyzed the levels of IFN-gamma in response to in vitro stimulation with ESAT-6, CFP10 and TB7.7, by QuantiFERON ®-TB Gold (In-tube method) (QTF-IT) in 155 participants: 47 patients confirmed pulmonary TB (patient group), 49 direct contacts (group contact), and 59 individuals without history or contact with TB (control group). The levels of IFN-gamma were different among the groups (p=0.0001); the highest level was observed in the patients group (median=1.43 IU/mL). In contacts group, 20/49 (40.8%) subjects were positive for the QTF-IT (median = 0.26 IU / mL), and among these positive contacts 14/20 (70.0%) exhibited high levels of IFN-gamma, (≥ 1.05 IU/mL). The performance testing of TB patients versus controls, resulted in 80.9% sensitivity (95% CI = 69.6% to 92.1%) and 93.2% specificity (95% CI = 86.8 % to 99.6%), but when the results of contacts and control group were combined, the specificity decreased to 77.8% (95% CI = 69.9% to 85.6%). Thus, according to our data, there is a distinctive profile of IFN-gamma, with higher levels in the patients group. The QTF-IT positive in contacts, especially those with high levels of IFN-gamma, should be monitored, especially those with high levels of IFN-gamma. This result may be a risk factor for developing TB disease. In addition, the QTF-IT, properly executed, can be useful in endemic areas for the diagnosis of latent and active TB (infection) when evaluated with other routine tests. / A Tuberculose (TB) é uma doença infecciosa causada por espécies do complexo Mycobacterium tuberculosis, que ao infectar os indivíduos expostos, iniciam uma resposta imunológica com produção de várias citocinas, dentre elas o Interferon-gama (IFN-gama), que é crucial para ativação da resposta imune celular contra o bacilo da TB. Esta citocina tem sido amplamente estudada como um possível biomarcador para auxiliar no diagnóstico da TB. Neste trabalho foram analisados as concentrações de IFN-gama em resposta a estímulos in vitro com ESAT-6, CFP10 e TB7.7, utilizando o QuantiFERON®-TB Gold (In-tube method) (QTF-IT), em 155 participantes, sendo: 47 pacientes com TB pulmonar confirmada (grupo paciente), 49 contatos de pacientes com TB pulmonar (grupo contato), e 59 indivíduos sem história e/ou contato com TB (grupo controle). As concentrações de IFN-gama foram diferentes entre os grupos avaliados (p=0,0001), sendo mais elevado nos pacientes com TB (Mediana = 1.43 UI/mL). Dos contatos diretos, 20/49 (40,8%) foram positivos para o QTF-IT (Mediana=0,26 UI/mL), e destes 14/20 (70,0%) apresentaram níveis elevados de IFN-gama, superior à 1,05 UI/mL. O desempenho do teste relacionando os pacientes de TB como os doentes e os controles como sadios, resultou em 80,9% de sensibilidade (IC 95% = 69,6% a 92,1%) e 93,2% de especificidade (IC 95% = 86,8% a 99,6%), mas quando os resultados dos contatos diretos foram adicionados aos controles, a especificidade reduziu para 77,8% (IC 95% = 69,9% a 85,6%). Concluiu-se que há um perfil diferenciado na produção de IFN-gama, com níveis mais elevados nos pacientes de TB ativa, e que os contatos positivos para o QTF-IT, principalmente, aqueles com altas concentrações de IFN-gama, devem ser monitorados, considerando que o perfil ou concentração elevado desta citocina, pode ser um fator de risco para o desenvolvimento da TB doença. Além disso, o QTF-IT, executado corretamente, pode ser útil em áreas endêmicas para auxiliar no diagnóstico da TB latente (infecção) e ativa, quando avaliados com outros exames de rotina.
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