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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
81

IFN-α and β restrict JC virus replication in primary human fetal glial cells : implications for progressive multifocal leukoencephalopathy therapy / IFN-alpha and beta restrict JC virus replication in primary human fetal glial cells

Co, Juliene Kimberly G January 2006 (has links)
Thesis (M.S.)--University of Hawaii at Manoa, 2006. / Includes bibliographical references (leaves 62-69). / viii, 69 leaves, bound ill. 29 cm
82

Induktion verschiedener Aktivitätsmuster über differentielle Rezeptor-Rekrutierung von Typ I IFN

Jaks, Eva Unknown Date (has links)
Univ., Diss., 2006--Frankfurt (Main)
83

Efficacy and immunological mechanisms of type 1 interferon gene therapy in murine cytomegalovirus /

Bartlett, Emmalene J. January 2002 (has links)
Thesis (Ph.D.)--Murdoch University, 2002. / Thesis submitted to the Division of Health Sciences. Bibliography: leaves 210-245.
84

Untersuchungen zur Struktur und Dynamik des Typ-I-Interferon-Rezeptors

Strunk, Jennifer Julia. Unknown Date (has links) (PDF)
Frankfurt (Main), Universiẗat, Diss., 2008.
85

Interferon, virus vaccines and antiviral drugs /

Rodrigues, Ana Mara Lopes. January 2007 (has links)
Thesis (Ph.D.) - University of St Andrews, December 2007.
86

Genetic polymorphisms of type I interferon receptor 1 affect the susceptibility to chronic HBV infection association analysis and mechanistic investigation /

Zhou, Jie, January 2007 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.
87

Interferon kinetics and its effect on DNA vaccine induced immunity in channel catfish (Ictalurus punctatus)

Harder, Kendal Thomas, Nusbaum, Kenneth E., January 2008 (has links) (PDF)
Thesis (M.S.)--Auburn University, 2008. / Abstract. Vita. Includes bibliographical references (p. 81-91).
88

The role of innate immunity in protection against respiratory syncytial virus (RSV)

Vaghefi, Negin Gitiban. January 2006 (has links)
Thesis (Ph. D.)--Ohio State University, 2006. / Available online via OhioLINK's ETD Center; full text release delayed at author's request until 2007 Mar 10
89

Cell biology of interferon inducible GTPases

Martens, Sascha. Unknown Date (has links) (PDF)
University, Diss., 2004--Köln.
90

Avaliação da concentração de Interferon-gama em pacientes com Tuberculose pulmonar e contatos diretos, por Quantiferon TB Gold (In tube method)

Santana Filho, Eduardo Bentes 17 May 2012 (has links)
Made available in DSpace on 2015-04-11T13:54:58Z (GMT). No. of bitstreams: 1 eduardo bentes.pdf: 1682417 bytes, checksum: be32237b0a1e23a7f3225f1419caf484 (MD5) Previous issue date: 2012-05-17 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis complex species, which infect the exposed individuals, initiate an immune response with production of several cytokines, among them interferon-gamma (IFN-gamma), which is crucial for activation of cellular immune response against TB bacillus. This cytokine has been extensively studied as a possible biomarker for diagnosis of TB. In this work, we analyzed the levels of IFN-gamma in response to in vitro stimulation with ESAT-6, CFP10 and TB7.7, by QuantiFERON ®-TB Gold (In-tube method) (QTF-IT) in 155 participants: 47 patients confirmed pulmonary TB (patient group), 49 direct contacts (group contact), and 59 individuals without history or contact with TB (control group). The levels of IFN-gamma were different among the groups (p=0.0001); the highest level was observed in the patients group (median=1.43 IU/mL). In contacts group, 20/49 (40.8%) subjects were positive for the QTF-IT (median = 0.26 IU / mL), and among these positive contacts 14/20 (70.0%) exhibited high levels of IFN-gamma, (≥ 1.05 IU/mL). The performance testing of TB patients versus controls, resulted in 80.9% sensitivity (95% CI = 69.6% to 92.1%) and 93.2% specificity (95% CI = 86.8 % to 99.6%), but when the results of contacts and control group were combined, the specificity decreased to 77.8% (95% CI = 69.9% to 85.6%). Thus, according to our data, there is a distinctive profile of IFN-gamma, with higher levels in the patients group. The QTF-IT positive in contacts, especially those with high levels of IFN-gamma, should be monitored, especially those with high levels of IFN-gamma. This result may be a risk factor for developing TB disease. In addition, the QTF-IT, properly executed, can be useful in endemic areas for the diagnosis of latent and active TB (infection) when evaluated with other routine tests. / A Tuberculose (TB) é uma doença infecciosa causada por espécies do complexo Mycobacterium tuberculosis, que ao infectar os indivíduos expostos, iniciam uma resposta imunológica com produção de várias citocinas, dentre elas o Interferon-gama (IFN-gama), que é crucial para ativação da resposta imune celular contra o bacilo da TB. Esta citocina tem sido amplamente estudada como um possível biomarcador para auxiliar no diagnóstico da TB. Neste trabalho foram analisados as concentrações de IFN-gama em resposta a estímulos in vitro com ESAT-6, CFP10 e TB7.7, utilizando o QuantiFERON®-TB Gold (In-tube method) (QTF-IT), em 155 participantes, sendo: 47 pacientes com TB pulmonar confirmada (grupo paciente), 49 contatos de pacientes com TB pulmonar (grupo contato), e 59 indivíduos sem história e/ou contato com TB (grupo controle). As concentrações de IFN-gama foram diferentes entre os grupos avaliados (p=0,0001), sendo mais elevado nos pacientes com TB (Mediana = 1.43 UI/mL). Dos contatos diretos, 20/49 (40,8%) foram positivos para o QTF-IT (Mediana=0,26 UI/mL), e destes 14/20 (70,0%) apresentaram níveis elevados de IFN-gama, superior à 1,05 UI/mL. O desempenho do teste relacionando os pacientes de TB como os doentes e os controles como sadios, resultou em 80,9% de sensibilidade (IC 95% = 69,6% a 92,1%) e 93,2% de especificidade (IC 95% = 86,8% a 99,6%), mas quando os resultados dos contatos diretos foram adicionados aos controles, a especificidade reduziu para 77,8% (IC 95% = 69,9% a 85,6%). Concluiu-se que há um perfil diferenciado na produção de IFN-gama, com níveis mais elevados nos pacientes de TB ativa, e que os contatos positivos para o QTF-IT, principalmente, aqueles com altas concentrações de IFN-gama, devem ser monitorados, considerando que o perfil ou concentração elevado desta citocina, pode ser um fator de risco para o desenvolvimento da TB doença. Além disso, o QTF-IT, executado corretamente, pode ser útil em áreas endêmicas para auxiliar no diagnóstico da TB latente (infecção) e ativa, quando avaliados com outros exames de rotina.

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