There is extensive research on depression and interpersonal problems, but research has not addressed these concepts in relation to mutuality and human motivation. Therefore, the purpose of the current study is to consider the associations between intimacy motivation and mutuality of closest relationships and how, when combined, the two connect to depressive experiences and the occurrence of interpersonal problems. Of the 7 original hypotheses suggested, 2 were supported while 5 were not. Perhaps the most interesting finding, and certainly the one with the most practical application, came from the two supported hypotheses. The analyses show that interpersonal problem subtypes are associated with specific depressive subtypes by operationalizing the demand/withdraw pattern of conflict. The exploratory findings also suggest a possible mediation of gender and depression by mutuality.