Introduction Krypton-81m is a radioactive gas with a half-life of 13 s, and found to be useful in many applications in nuclear medicine, particularly for lung perfusion studies and ventilations. Due to high demands for 81mKr, we have developed an automated Krypton system to be installed in one of the Cyclotron’s beamlines at King Faisal Specialist Hospital and Research Centre (KFSH&RC) and to deliver large activity of the radioactive gas. Material and Methods The effective cross section of producing 81Rb is between 15 and 30 MeV [1]. Therefore, range and stopping power of the effective cross section were calculated with respect to gas density of 0.0185 g/cm3. This value is equivalent to gas density at 5.0 bars at room temperature. SRIM calculations resulted in a range of 589 mm. However, due to limitation in fabricating such long target chamber, the target length is chosen to be 250 mm. Attached to the end of target body is a special water circulating flange ‘back-pool’, its purpose is to absorb the rest of the energy and protons Bragg peak. The target body is made of Aluminum with the inner part being electroplated with nickel. The target body is of conical shape. The target body is electrically isolated from other parts to allow accurate beam current reading. Full access to the target loading/unloading steps is made through touch screen technology (FIG. 2) for user access. Additionally, the target control system is designed to be protected through chain of interlock steps. The production cycle of 81Rb is explained as follow. Target is evacuated to approximately 10−3 mbar before being filled with natKr at pressure of 5 bars. At the end of bombardment, recovery of natKr is done via cryogenic vessel. Finally, the radioactivity is washed with KCl and pushed to Hotcells through the nitrogen gas for chemistry processing. Irradiation time was approximately 30 min. Results and Conclusion Experimental results clearly showed a fairly good activity of 81mKr as shown in TABLE 1. In all experiments, the radionuclidic purity of 81mKr was above 99.59%. 79mKr and 79Kr were also measured with a percentage of, respectively, 0.34 and 0.07 %. Special attention has to be drawn to last experiment where the yield significantly in-creased, due to the period where the KCl left inside the target (10 min) before pushing the solution to the Hotcells