Thesis (Ph. D.)--University of Wisconsin--Madison, 1964. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 75-81).

Thesis (M.S.)--Baylor University, 2006. / Includes bibliographical references (p. 56-62).

Thesis (M.S.)--Oregon State University, 2007. / Printout. Includes bibliographical references (leaves 67-72). Also available on the World Wide Web.

Bibliography: leaves 200-214. Three structurally related compounds, 2-acetyltetrahydropyridine (ACTPY), 2-ethyltetrahydropyridine (ETPY) and N-heterocycle, 2-acetyl-1-pyrroline (ACPY), were quantified and found to be unique components of mousy wines. 35 lactic acid bacteria (LAB) were screened for the ability to produce mousy off-flavour. In addition to Lactobacillus brevis and L. cellobiosus, a diversity of LAB species, particularly heterofermentative Lactobacillus spp. and Oenococcus oeni exhibited this ability in a range of ethanolic and wine-based media. The substrates and metabolism of mousy compound formation by LAB were also investigated. A pathway for the formation of ACPY and ACTPY by heterofermentative LAB was proposed.

Made available in DSpace on 2014-06-11T19:31:36Z (GMT). No. of bitstreams: 0 Previous issue date: 1999-09-08Bitstream added on 2014-06-13T20:02:28Z : No. of bitstreams: 1 demiate_im_dr_botfca.pdf: 774637 bytes, checksum: e92983a3fd6330d2a52bcb9b1cca87aa (MD5) / A produção de fécula de mandioca fermentada e seca ao sol (polvilho azedo) em alguns países da América do Sul, citada na literatura, é um exemplo de geração da propriedade funcional denominada auto-expansão. O polvilho azedo é empregado na elaboração de produtos alimentícios em caráter comercial. Estudos da propriedade de expansão do polvilho azedo possibilitaram concluir que a exposição de fécula de mandioca tratada com ácido lático a radiação ultravioleta (UV)* é capaz de promover o aparecimento dessa propriedade. No presente trabalho propõe-se o desenvolvimento de féculas de mandioca auto-expansíveis modificadas por processo químico simplificado se comparado à obtenção do polvilho azedo ou da fécula tratada com ácido lático e irradiada com UV. Esse processo consta da oxidação da fécula de mandioca com solução de permanganato de potássio e posterior suspensão dessa fécula em solução de ácido lático. As amostras secas em estufa são lavadas para remoção do excesso de reagentes. As lavagens não... / The production of fermented and sundried cassava starch (cassava sour starch) in some countries of South America, as described in the literature, is an example of generation of the functional property denominated expansion ability (auto-expansion). In Brazil, this fermented starch is commercially employed in the production of several food products. Studies about physico-chemical characteristics of cassava sour starch indicated that UV-irradiation of lactic acid treated cassava starch* generated modified starches that expanded just as cassava sour starch. In the present work the development of chemically modified cassava starch is proposed by a chemical process less complex than that employed on the production of cassava starches presenting expansion ability (cassava sour starch or UV-irradiated lactic acid treated cassava starch). This process involves previous oxidation of native cassava starch with potassium permanganate, followed by suspension in lactic acid solution. The samples are oven-dried before or after being washed to promote the removal of excess reagents. Washings do not influence the expansion of the modified samples. Oxidized starches described in the literature form clear and low viscosity pastes and are used mainly at the textile and paper industry. Their expansion property, however, was never... (Complete abstract click electronic access below)

Made available in DSpace on 2014-06-11T19:31:37Z (GMT). No. of bitstreams: 0 Previous issue date: 1999-09-10Bitstream added on 2014-06-13T19:02:03Z : No. of bitstreams: 1 nunes_olgs_dr_botfca.pdf: 4096573 bytes, checksum: 99012f6e89c30cced07f84f9b82666c3 (MD5) / Not available

Orientador: Marney Pascoli Cereda / Coorientador: Gilvan Wosiacki / Banca: José Renato Cagnon / Banca: Marcia Miguel Castro Ferreira / Banca: Olivier Vilpoux / Banca: José Luis Agapito Fernandes / Resumo: A produção de fécula de mandioca fermentada e seca ao sol (polvilho azedo) em alguns países da América do Sul, citada na literatura, é um exemplo de geração da propriedade funcional denominada auto-expansão. O polvilho azedo é empregado na elaboração de produtos alimentícios em caráter comercial. Estudos da propriedade de expansão do polvilho azedo possibilitaram concluir que a exposição de fécula de mandioca tratada com ácido lático a radiação ultravioleta (UV)* é capaz de promover o aparecimento dessa propriedade. No presente trabalho propõe-se o desenvolvimento de féculas de mandioca auto-expansíveis modificadas por processo químico simplificado se comparado à obtenção do polvilho azedo ou da fécula tratada com ácido lático e irradiada com UV. Esse processo consta da oxidação da fécula de mandioca com solução de permanganato de potássio e posterior suspensão dessa fécula em solução de ácido lático. As amostras secas em estufa são lavadas para remoção do excesso de reagentes. As lavagens não... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The production of fermented and sundried cassava starch (cassava sour starch) in some countries of South America, as described in the literature, is an example of generation of the functional property denominated expansion ability (auto-expansion). In Brazil, this fermented starch is commercially employed in the production of several food products. Studies about physico-chemical characteristics of cassava sour starch indicated that UV-irradiation of lactic acid treated cassava starch* generated modified starches that expanded just as cassava sour starch. In the present work the development of chemically modified cassava starch is proposed by a chemical process less complex than that employed on the production of cassava starches presenting expansion ability (cassava sour starch or UV-irradiated lactic acid treated cassava starch). This process involves previous oxidation of native cassava starch with potassium permanganate, followed by suspension in lactic acid solution. The samples are oven-dried before or after being washed to promote the removal of excess reagents. Washings do not influence the expansion of the modified samples. Oxidized starches described in the literature form clear and low viscosity pastes and are used mainly at the textile and paper industry. Their expansion property, however, was never... (Complete abstract click electronic access below) / Doutor

Dissertation submitted in compliance with the requirements for the Master's Degree in Technology: Homoeopathy, Technikon Natal, 1999. / The action of homoeopathic medicine on physiological processes is poorly understood. It is hypothesized that homoeopathic potencies of Sarcolactic acid could have an effect in increasing the metabolism of lactate in the body, lowering its concentration change due to exercise, and thus reduce exercise fatigue. There is a need to investigate whether a homoeopathic remedy made from a physiological chemical can influence the action of this chemical in the body. Much has been done on the influence of homoeopathy on toxins, and their detrimental effects, but little is known of its effects 0(1 metabolic by-products and the influence of hqmoeopathy on their regulation / M

Thesis advisor: Jeffery A. Byers / This dissertation discusses the development of a family of iron complexes and their role in the synthesis of degradable polymers. Chapter one will introduce the different areas of redox-switchable polymerization. In chapter two the synthesis of block copolymers containing a polyester and polyether block is presented. The application redox-switchable polymerization to form a copolymer with two fundamentally distinct backbone functionalities and their characterization is discussed. In chapter three the synthesis of a degradable cross-linked polymer through a novel redox-triggered cross linking event is summarized. In chapter four, a detailed mechanistic study of iron-complex catalyzed epoxide polymerization is examined and a unique mechanistic scheme is proposed. Lastly, in chapter five the synthesis and characterization of a formally iron(I) complex is presented. This complex shows remarkable catalytic activity towards ring-opening polymerization. / Thesis (PhD) — Boston College, 2018. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry.

Sexually transmitted infections (STIs) such as gonorrhea, herpes simplex virus 2 (HSV 2), hepatitis C, human papilloma viruses (HPV) and human immunodeficiency virus type 1 (HIV) are a global health concern affecting millions of lives. Although extensive efforts have been geared towards prevention and treatment of STIs, little progress has been achieved. Recently, efforts to develop microbicides have been focused on the commensal bacterial species that comprise the vaginal microbiome and their role in immunity and disease pathogenesis. The lower FRT which includes the cervix and vagina has endogenous bacterial species that are supported by the mucosal epithelium. Lactobaccilli are the dominant endogenous bacterial species in the vagina of most women; lactobacilli convert glycogen to lactic acid (LA) which maintains a low pH environment in the vagina and serves as a deterrent to infectious organisms. The purpose of this research project was to determine the effects of LA on vaginal integrity and inflammation in a vaginal epithelial cell (VEC) tissue model, and on the ability of the broadly neutralizing anti-HIV antibody, VRCO1, to inactivate HIV in vitro. Effects of LA exposure on the viability and integrity of vaginal epithelium were determined by histology, MTT assay and measurement of transepithelial electric resistance (TEER). In addition, an enzyme-linked immunosorbent assay (ELISA) was used to measure concentrations of cytokines secreted by the VEC epithelial cells in response to different doses of LA. Using TLR agonists to simulate infection in the VEC model, we tested the hypothesis that LA has anti-inflammatory properties that modulate immune responses of the vaginal epithelium. We assessed the effect of LA on the neutralization activity of the anti-HIV-1 monoclonal antibody VRCO1 in the TZM-bl HIV neutralization assay. Tissue morphology and integrity were not affected by exposure to LA. Low concentrations of IL-1β and RANTES were expressed by VEC tissues in response to L-LA treatment. VEC tissues expressed significantly elevated concentrations of IL-1RA (p<0.0001), an anti-inflammatory cytokine, in response to LA regardless of incubation time and LA doses. In addition, treatment of VEC tissues with Poly I: C in the presence of LA dampened upregulated expression of IL-1β, TNF-alpha and IL-6 in response to the TLR 3 agonist. LA also elicited significantly higher IL-1RA concentrations when apically added to the TLR agonist-treated VEC tissues. These data suggest that LA elicits an anti-inflammatory response in the vaginal epithelium. LA acidic conditions as low as pH 3.5 did not affect the ability of VRC01, to prevent HIV infection. We found that LA, at concentrations present in vaginal secretions of normal women, inhibited the inflammatory response to a TLR agonist, possibly due to upregulated Il-1RA synthesis. In addition, the functionality of VRCO1 in an acidic milieu was not diminished, providing evidence that antibodies can function in the low pH vaginal environment. This report highlights the potential use of LA in the vagina as a microbicide due to its virucidal activity and anti-inflammatory properties. It also indicates that monoclonal antibody-based vaginal microbicides will not be neutralized by LA. There is still a need to elucidate the exact mechanisms by which LA confers immuno-modulatory properties within the female reproductive tract.