No description available.

Dependencies between program elements can reflect the architecture, design, and implementation of a software project. According a industry report, intra- and inter-module dependencies can be a significant source of latent threats to software maintainability in long-term software development, especially when the software has millions of lines of code. This thesis introduces the design and implementation of an accurate and scalable analysis tool that extracts code dependencies from large C/C++ software projects. The tool analyzes both symbol-level and module-level dependencies of a software system and provides an utilization-based dependency model. The accurate dependencies generated by the tool can be provided as the input to other software analysis suits; the results along can help developers identify potential underutilized and inconsistent dependencies in the software. Such information points to potential refactoring opportunities and assists developers with large-scale refactoring tasks.

The lake sturgeon, Acipenser fulvescens, was once abundant throughout Canada and the United States, however, high commercial harvests and habitat alterations have dramatically reduced most populations. The species was extirpated from many rivers that it once inhabited, and has been designated as threatened or endangered throughout its range. Currently, few healthy lake sturgeon populations remain and the species is receiving considerable attention with respect to its protection and recovery. Although considerable effort is underway to conserve the species, several factors, including over-harvest and habitat alteration, pollution and a general lack of understanding about lake sturgeon ecology and behavior continue to hamper recovery efforts. This thesis examined the ecology and behavior of juvenile lake sturgeon within a 41 km long impounded section of the Winnipeg River, a large river in the Canadian Shield, over a three-year period (2006 – 2008). Habitat preferences, species associations, diet, and movement were described on a seasonal basis. Biological characteristics were also described for juvenile lake sturgeon within the study area. Studies presented in this thesis are among the first conducted for juveniles of this species in the Hudson Bay drainage basin, and from large riverine environments in general. Results are important, not only for improving our understanding of lake sturgeon at the juvenile life history stage, but for facilitating further research. In particular, future research studies identified in the final chapter have the potential to enhance our understanding of factors influencing mortality during the early life history stages of the lake sturgeon, and therefore, greatly enhance recovery efforts.

Autoclave processing of large scale, one-piece structural parts made of carbon fiber-reinforced polymer composite materials is the key to decreasing manufacturing costs while at the same time increasing quality. Nonetheless, even in manufacturing simple flat parts, residual strains and stresses are unavoidable. For structural design purposes and to aid in the assembly procedures, it is desirable to have proven numerical tools that can be used to predict these residual geometrical and material properties in advance, thus avoid the costly experimental trial and error methods. A 2-D finite element-based code, COMPRO, has previously been developed in-house for predicting autoclave process-induced deformations and residual stresses in composite parts undergoing an entire cure cycle. To simulate the tool-part interaction, an important source of residual deformations/stresses, COMPRO used a non-zero thickness elastic shear layer as its only interface option. Moreover, the code did not account for the large deformations and strains and the resulting nonlinear effects that can arise during the early stages of the cure cycle when the material is rather compliant. In the present work, a contact surface employing a penalty method formulation is introduced at the tool-part interface. Its material-dependent parameters are a function of temperature, degree of cure, pressure and so forth. This makes the stick-slip condition plus separation between the part and the tool possible. The large displacements/rotations and large shear strains that develop at the early stages of the cure cycle when the resin has a very low elastic modulus provided the impetus to include a large strain/deformation option in COMPRO. A new “co-rotational stress formulation” was developed and found to provide a robust method for numerical treatment of very large deformation/strain problems involving anisotropic materials of interest here. Several verification and validation examples are used to calibrate the contact interface parameters and to demonstrate the correctness of implementation and the accuracy of the proposed method. A number of comparisons are made with exact solutions, other methods, other experiments and the same models in other commercial codes. Finally, several interesting cases are examined to explore the results of COMPRO predictions with the added options.

The abstraction provided by virtual memory is central to the operation of modern operating systems. Making the most efficient use of the available translation hardware is critical to achieving high performance. The multiple page-size support provided by almost all architectures promises considerable benefits but poses a number of implementation challenges. This thesis presents a minimally-invasive approach to transparent multiple page-size support for Itanium Linux. In particular, it examines the interaction between supporting large pages and Itanium's two inbuilt hardware page-table walkers; one being a virtual linear page-table with limited support for storing different page-size translations and the other a more flexible but higher overhead hash table based translation cache. Compared to a single-page-size kernel, a range of benchmarks show performance improvements when multiple page-sizes are available, generally large working sets that stress the TLB. However, other benchmarks are negatively impacted. Analysis shows that the increased TLB coverage, resulting from the use of large pages, frequently does not reduce TLB miss rates sufficiently to make up for the increased cost of TLB reloads. These results, which are specific to the Itanium architecture, suggest that large-page support for Itanium Linux is best enabled selectively with insight into application behaviour.

The current project is to develop a transient expression system for Chinese Hamster Ovary (CHO) cells based on autonomous replication and retention of plasmid DNA. The expression system, named Epi-CHO comprises (1) a recombinant CHO-K1 cell line encoding the Polyoma (Py) virus large T-Antigen (PyLT-Ag), and (2) a DNA expression vector, pPy/EBV encoding the Py Origin (PyOri) for autonomous replication and encoding the Epstein-Barr virus (EBV), Nuclear Antigen-1 (EBNA-1) and EBV Origin of replication (OriP) for plasmid retention. The CHO-K1 cell line expressing PyLT-Ag, named CHO-T was adapted to suspension growth in serum-free media (EXCELL-302) to facilitate large scale transient transfection and recombinant (r) protein production. PyLT-Ag-expressed in CHO-T supported replication of PyOri-containing plasmids and enhanced growth and r- protein production. A scalable cationic lipid based transfection was optimised for CHO-T cells using LipofectAMINE-2000??. Destabilised Enhanced Green Fluorescence Protein (D2EGFP) and Human Growth Hormone (HGH) were used as reporter proteins to demonstrate transgene expression and productivity. Transfection of CHO-T cells with the vector pPy/EBV encoding D2EGFP showed prolonged and enhanced EGFP expression, and transfection with pPy/EBV encoding HGH resulted in a final concentration of 75 mg/L of HGH in culture supernatant 11 days following transfection.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1970. / Typescript. Vita. Description based on print version record. Includes bibliographical references.

Thesis (doctoral)--Rheinische Friedrich-Wilhelms-Universität Bonn, 1996. / Includes bibliographical references (p. 121).

La radiogoniométrie consiste à mesurer l’angle d’incidence de signaux électromagnétiques. Elle a pour applications principales le contrôle du spectre et la guerre électronique. Dans le domaine des réseaux d’antennes pour la radiogoniométrie, de nouvelles problématiques sont apparues alors que les algorithmes de traitement d’antenne se perfectionnent. Ces dernières concernent la largeur de bande, la compacité et la diversité de polarisation. De précédents travaux ont initié la démarche de conception de telles antennes et réseaux pour la radiogoniométrie. L’objectif de ce travail de recherche a consiste en premier lieu a proposer une antenne de dimensions réduites opérant dans les bandes V/UHF et présentant une diversité de polarisation. Par la suite, il s’est agi de concevoir un réseau fonctionnel de radiogoniométrie intégrant l’antenne développe. Une antenne planaire de dimensions 150mm x 150mm (λ/4 x λ/4) a alors été conçue et réalisée entre 500 MHz et 3000 MHz. Sa mise en réseau permet des performances angulaires de l’ordre de 2° et moins sur la même bande pour des dimensions de 260mm (diamètre) x 150mm (hauteur) soit λ/2,3 x λ/4. Par la même occasion, un absorbant de faible épaisseur (25mm soit λ/24) a été développé et mesuré. Il permet une augmentation du rapport avant/arrière d’au moins 10dB de l’antenne développe sur sa bande de fonctionnement. / Radio direction finding (DF) allows for the measurement of the direction of arrival of incoming electromagnetic signals. Its main applications include spectrum monitoring and electronic warfare. DF antennas and arrays are subject to new problematics (bandwidth, compactness and polarization diversity) while DF algorithms have kept on improving. Previous works have initiated the design of such antennas and arrays. This work aims at designing an antenna with reduced dimensions for the VHF and UHF frequency bands and with a polarization diversity. This antenna shall then be integrated in a functional DF array. For this purpose, a planar antenna has been designed and measured in the 500-3000 MHz frequency band. Its final dimensions are 150mm x 150mm (λ/4 x λ/4). This antenna has then been integrated in the final DF array whose accuracy on the same frequency band is of the order of 2° for a final size of 260mm (diameter) x 150mm (height), that is λ/2,3 x λ/4. This study has also allowed for the design of a low-profile absorber (with a height of 25mm, that is λ/24 at its lowest frequency of operation). An increase of 10dB in the front to back ratio of the proposed antenna has been enabled by this absorber on its whole frequency band.

It has long been known that the presence of wood in rivers plays a vital biological and functional role and that a reciprocal relationship exists between woody material and the geomorphology of rivers. Fluvial wood studies, however, are rarely ongoing through time in order to ascertain long-term wood patterns within complete drainage networks. This dissertation addresses the temporal lag in fluvial wood patterns throughout four watersheds in the Oregon Coast Range by recreating a field dataset first collected in 1979 and then again in 1998. Statistical and spatial analysis of stream morphometric data at designated transects throughout the watersheds in addition to analysis of log step and log jam inventories provide insight into significant changes that have occurred over a thirty year interval at a multi-basin scale. These watersheds are located in areas that have been impacted by years of timber harvesting in the mid-twentieth century, however, clearcutting has been on the decline since the early 1980s. This research investigates the impacts that the legacy of clearcutting and subsequent afforestation has had on the abundance and volume of fluvial wood in the stream networks of these four watersheds. I digitized historical aerial imagery to determine the amounts of clearcutting in the basins over time. I integrated this variable with channel morphometric variables to assess predictors of wood abundance and volume through multiple regression analysis. Results show that the stream that has been the most affected by clearcutting has lower volumes of wood than measured in 1979 or 1998. Residence times of wood are short in these watersheds and wood abundance and volume was highly impacted by the debris flows that occurred during the Storm of 1996, prior to the 1998 data collection. There are statistically significant changes that have occurred in the stream morphology among the four watersheds. This dissertation also tests a method of detecting fluvial wood through airborne lidar analysis. This method provides an alternative to field surveys in areas of even the most extreme tree canopy cover.