No description available.

No description available.

This thesis is based around detailed analysis of an assemblage of newly excavated material from the Paphos Theatre site in SW Cyprus. Before presenting the new work, the academic context into which it must fit is investigated. This process of re-evaluating past work sets up a framework within which the new material would be expected to fit. In fact, research on Late Roman Cyprus is not as advanced as might be expected after over seventy years of excavation. This is most particularly the case for fundamental principles like typology and chronology for the local ceramics and glass. A review of past and current excavations shows that the typology of Cypriot Red Slip ware is widely used around the Eastern Mediterranean as a dating tool for deposits containing this distinctive Fine ware. This makes it essential that it be confirmed to be a reliable and substantially correct construct. Unfortunately, a re-analysis of the foundations of the Cypriot red Slip ware typology and chronology reveals many uncertainties and establishes the necessity for new material from secure deposits to help refine current typologies. The artefact assemblage from Area Three at the Paphos Theatre provides just such an opportunity. A combination of a series of sealed deposits, a high density of artifacts and identifiable coins has enabled a comprehensive study to be achieved. A major collapse, probably an earthquake, sealed a paved street and drainage system in the trenches and this episode can be pinpointed to around the mid to late fifth century by the coin evidence. Most interesting is the fact that the dating suggested by the coins does not match the dating usually assigned to the associated pottery and glass. After establishing the reliability of the coin evidence, the study of the other artefacts offers new ideas about the dating and typology of the local Cypriot Red Slip ware, Cooking ware, Lamps and Glass. In fact an analysis of all the pottery from the site suggests that the chronology of Cypriot Red Slip ware and Cooking ware in particular needs to be pushed back to focus on a floruit in the fourth and fifth centuries. This is at least one hundred years earlier than current typologies that focus on the mid sixth to seventh centuries. This analysis provides some reliable fixed points, for both local pottery and glass, earlier in the Late Roman sequence upon which future work can be built.

Thesis (Ph. D.)--Universität Hamburg, 1986. / Vita. Includes bibliographical references (p. 346-365). Also issued in print.

Thesis (Ph. D.)--Universität Hamburg, 1986. / Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (p. 346-365).

Proefschrift--Leyden. / "Bijlagen" (dated 1423-1432): p. [91]-160. Includes bibliographical references (p. viii-xiii).

Thesis (Ph. D.)--University of Hong Kong, 2002. / Includes bibliographical references (leaves 91-107).

Thesis (Ph.D.)--University of Hong Kong, 2002. / Includes bibliographical references (leaves 91-107) Also available in print.

Thesis (doctoral)--Uppsala University, 1987. / Includes bibliographical references (p. 230-238).

Orientador: Lígia Maria Suppo Souza Rugolo / Resumo: A sepse neonatal tardia é importante causa de morbidade e mortalidade em recém-nascidos prematuros. Os sinais e sintomas são inespecíficos, o que dificulta o diagnóstico. As citocinas são potentes mediadores inflamatórios que desempenham importante papel na patogênese da infecção. Níveis séricos aumentados de citocinas são observados durante infecções. A Interleucina 8 (IL-8) tem função de atrair e ativar neutrófilos, mantendo o processo inflamatório. O objetivo deste estudo foi determinar os níveis séricos e urinários da IL-8 em recém-nascidos prematuros com sepse tardia confirmada por culturas (sangue, urina ou líquor) ou associada com meningite, e avaliar se os níveis urinários de IL-8 podem ser utilizados como teste diagnóstico da sepse neonatal tardia. Amostras de sangue e urina foram coletadas de 36 RN prematuros com suspeita clínica de sepse tardia e os exames foram repetidos após 48 horas do início do estudo. Os valores séricos e urinários da IL-8 foram determinados pelo método de ELISA e a IL-8 urinária foi ajustada pelo valor da creatinina urinária. Dois grupos foram constituídos: Grupo séptico: 19 RN com sepse confirmada por culturas ou associada a meningite, idade gestacional (IG) de 31 ± 2,5 semanas, peso de nascimento (PN) de 1350 ± 420g, idade pós-natal (IPN) de 9,7 ± 5,3 dias e Grupo não infectado: 17 RN nos quais o diagnóstico de sepse foi excluído, IG 31 ± 2,1 sem, PN 1510 ± 380g, IPN 6,9 ± 4,1 dias. A mediana dos níveis séricos da IL-8 não diferiu estatisticamente entre os grupos séptico e não infectado (929 x 624 pg/ml; p=0,079) mas os níveis urinários (IL-8 ur/cr) foram significativamente maiores no grupo séptico (249 x 41,7; p<0,001). O ponto de corte ótimo da IL-8 sérica foi de 304 pg/ml com sensibilidade de 84% (IC 95%: 60 a 95%) e especificidade de 47% (IC 95%: 23 a 72%)... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Late onset sepsis (LOS) is an important cause of morbidity and mortality in preterm infants. However, the diagnosis of LOS is difficult. Elevated serum levels of cytokines have been found during infections and this plays a critical role in the pathogenesis of infections. Interleukin 8 (IL-8) attracts and activates neutrophils which is crucial for the maintenance of the inflamatory process. The aim of this study was to determine serum and urine IL-8 levels in preterm infants with clinical LOS and positive culture (blood, urine ou cerebrospinal fluid) or meningitis and to evaluate if IL-8 levels can be a useful test for the diagnosis of LOS. Blood and urine were obtained from 36 premature babies with clinical signs of LOS and the collection of the samples were repeated after two days. Serum and urine IL-8 levels were determined by ELISA and the urine IL-8 concentration was corrected with the urine creatinine level. Nineteen preterm infants with sepsis (positive cultures or meningitis) - LOS Group: gestational age (GA) 31 ± 2.5wk, Birth Weight (BW) 1.35 ± 0.42 Kg, postnatal age(PNA) 9.7 ± 5.3 days and 17 noninfected - Control Group: GA 31 ± 2.1wk, BW 1.51 ± 0.38, PNA 6.9 ± 4.1 days, were studied. The medium serum IL-8 levels were not statistically different between groups (LOS vs Control, 929 x 624 pg/ml; p=0,079) but urine IL-8 levels were significantly higher in the LOS group when compared with the noninfected (249 x 41,7 p<0,001). The optimal cut-off point was 304pg/ml for serum IL8 with 84% sensitivity (95% CI: 60-95%) and 47% specificity (95% CI: 23-72%). The cut-off point for urine IL-8 was 89 with 100% sensitivity (95% CI: 82-100%) and 100% specificity (95%CI:81-100%). Two days after of clinical signs of LOS, urine IL-8 levels decreased in LOS group (p<0,001). The decrease in serum IL-8 levels in the LOS group was not statistically different (p=0,123)... (Complete abstract, click electronic address below) / Doutor