261 |
Structural basis of RhoA activation by leukemia-associated RhoGEFKristelly, Romana, 1972- 28 August 2008 (has links)
Not available / text
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262 |
Study of gene promoter methylation in acute promyelocytic leukaemiaChim, Chor-sang, James., 詹楚生 January 2002 (has links)
published_or_final_version / abstract / toc / Medicine / Master / Doctor of Medicine
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263 |
Generation and functional characterization of dendritic cells from bone marrow of patients with leukaemia diseases and various haemato-oncological conditionsChan, Shing, 陳誠 January 2002 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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264 |
The combined effect of Chinese medicinal extract polysaccharide peptide (PSP) and the chemotherapeutic agents-cytarabine, doxorubicinand etoposide in human leukemic cells and normal human T-lymphocytesHui, Pui-yan., 許珮茵. January 2003 (has links)
published_or_final_version / abstract / toc / Zoology / Master / Master of Philosophy
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265 |
Pharmacokinetics of homoharringtonine in Chinese leukemia patients李富榮, Lee, Foo-wing. January 1990 (has links)
published_or_final_version / Biochemistry / Master / Master of Philosophy
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266 |
Clonal rearrangement of T-cell receptor delta gene in hematological malignancies and applications in detection of minimal residualdisease陳衛, Chan, Wai. January 1995 (has links)
published_or_final_version / Medicine / Master / Master of Philosophy
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267 |
Studies of the cell cycle and regulatory processes in the mouse leukemia cell L5178YBiehl, Ruth Berneice Ludtke January 1979 (has links)
No description available.
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268 |
The effect of three polycyclic aromatic hydrocarbons on Friend virus leukemia in BALB/c miceKiehn, Winifred Kiger, 1942- January 1967 (has links)
No description available.
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269 |
The influence of 7, 12-dimethylbanz(a) anthracene on virus titer and spleen weight in Friend virus leukemiaReilly, Christopher Aloysius, 1942- January 1966 (has links)
No description available.
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270 |
Identification of differentially expressed genes in AHI-1-mediated leukemic transformation in cutaneous t-cell lymphomaKennah, Erin 11 1900 (has links)
The oncogene Ahi-1 was recently identified through provirus insertional mutagenesis in murine leukemias and lymphomas. Its involvement in human leukemogenesis is demonstrated by gross perturbations in its expression in several leukemic cells lines, particularly in cutaneous T-cell lymphoma (CTCL) cell lines (Hut 78 and Hut 102). Hut 78 is derived from a patient with Sezary syndrome, a common leukemic variant of the human CTCL mycosis fungoides. Aberrant expression of AHI-1 mRNA and protein has been found in CD4⁺CD7⁻ leukemic Sezary cells from patients with Sezary syndrome. Moreover, stable suppression of AHI-1 using retroviral-mediated RNA interference in Hut 78 cells inhibits their transforming activity in vitro and in vivo. In an effort to identify genes involved in AHI-1-mediated leukemic transformation in CTCL, microarray analysis was performed to compare six RNA samples from AHI-1 suppressed Hut 78/sh4 cells to five samples from Hut 78 control cells. Limma and dChip analyses identified 218 and 95 differentially expressed genes, respectively, using a fold change criteria of > or < 2 and a p-value threshold of ≤ 0.01. After evaluation of both analyses, 21 genes were selected based upon interesting structural and functional information, specificity to hematopoietic cells or T-cells, and previous connections to cancer. Expression patterns of these 21 genes were validated by qRT-PCR with p-values < 0.05 ranging from 1.97 x 10⁻¹⁰ to 6.55 x 10⁻³, with the exception of BRDG1 at 5.88 x 10⁻². The observed up-regulation of both BIN1 and HCK in AHI-1 suppressed Hut 78/sh4 cells as compared to control cells further confirmed at the protein level. The tumor suppressor BIN1 is known to physically interact with c-MYC, which also exhibits differential protein expression in these cells. Characterization of BIN1 identified 4 isoforms all of which contain exon 10 and demonstrate alternative splicing of exons 12A and 13. Additionally, qRT-PCR results from primary Sezary samples indicate there is clinical significance in the expression changes detected for BIN1, HCK, REPS2, BRDG1, NKG7 and SPIB. These findings identify several new differentially expressed genes that may play critical roles in AHI-1-mediated leukemic transformation of human CTCL cells.
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