In this dissertation, we first derive exact reconstuction algorithms for thermoacoustic tomography (TAT) and broadband diffraction tomography (a linearized inverse scattering problem) using derived time-reversal formulas. Then we focus on some important practical problems of TAT including the limited-view problem, the effects of acoustic heterogeneity, and fast reconstruction algorithms. In Chapter II, we propose time-reversal methods and apply them to tomography with diffrating sources. We first develop time-domain methods to time-reverse a transient scalar wave using only the field measured on an arbitrary closed surface enclosing the initial sources. Under certain conditions, a time-reversed field can be obtained with the delay-and-sum algorithm (backprojection to spheres) used in synthetic aperture imaging.Consequently, the physicalmeaningandthe validconditions of this widely used algorithm are revealed quantitatively for the first time from basic physics. Then exact reconstruction for TAT and broadband diffraction tomography is proposed by time-reversing the measured field back to the time when each source or secondary source is excited. The theoretical conclusions are supported by a numerical simulation ofthree-dimensional diffraction tomography.The extension ofour time-reversal methods to the case using Green function in a heterogeneous medium is also discussed. In Chapter III, the limited-view problem is studied for TAT. We define a "detection region," within which all points have sufficient detection views. It is explained analytically and shown numerically that the boundaries of any object inside this region can be recovered stably.Otherwise some sharp details become blurred.One can identify in advance the parts of the boundaries that will be affected if the detection view is insufficient. Computations are conducted for both numerically simulated and experimental data. The reconstructions confirm our theoretical predictions. In Chapter IV, the effects of wavefront distortions induced by acoustic heterogeneities in breast TAT are studied. Amplitude distortions are shown to be insignificant for different scales of acoustic heterogeneities. After that we consider the effects of phase distortions (errors in time-of-flight) in our numerical studies. The numerical results on the spreads of point sources and boundaries caused by the phase distortions are in good agreement with the proposed formula. We also demonstrate that the blurring of images can be compensated for by using the distribution of acoustic velocityin the tissues in the reconstructions. In Chapter V, we discuss exact and fast Fourier-domain reconstruction algorithms for TAT in planar and circular configurations.

In this dissertation, we first derive exact reconstuction algorithms for thermoacoustic tomography (TAT) and broadband diffraction tomography (a linearized inverse scattering problem) using derived time-reversal formulas. Then we focus on some important practical problems of TAT including the limited-view problem, the effects of acoustic heterogeneity, and fast reconstruction algorithms. In Chapter II, we propose time-reversal methods and apply them to tomography with diffrating sources. We first develop time-domain methods to time-reverse a transient scalar wave using only the field measured on an arbitrary closed surface enclosing the initial sources. Under certain conditions, a time-reversed field can be obtained with the delay-and-sum algorithm (backprojection to spheres) used in synthetic aperture imaging.Consequently, the physicalmeaningandthe validconditions of this widely used algorithm are revealed quantitatively for the first time from basic physics. Then exact reconstruction for TAT and broadband diffraction tomography is proposed by time-reversing the measured field back to the time when each source or secondary source is excited. The theoretical conclusions are supported by a numerical simulation ofthree-dimensional diffraction tomography.The extension ofour time-reversal methods to the case using Green function in a heterogeneous medium is also discussed. In Chapter III, the limited-view problem is studied for TAT. We define a "detection region," within which all points have sufficient detection views. It is explained analytically and shown numerically that the boundaries of any object inside this region can be recovered stably.Otherwise some sharp details become blurred.One can identify in advance the parts of the boundaries that will be affected if the detection view is insufficient. Computations are conducted for both numerically simulated and experimental data. The reconstructions confirm our theoretical predictions. In Chapter IV, the effects of wavefront distortions induced by acoustic heterogeneities in breast TAT are studied. Amplitude distortions are shown to be insignificant for different scales of acoustic heterogeneities. After that we consider the effects of phase distortions (errors in time-of-flight) in our numerical studies. The numerical results on the spreads of point sources and boundaries caused by the phase distortions are in good agreement with the proposed formula. We also demonstrate that the blurring of images can be compensated for by using the distribution of acoustic velocityin the tissues in the reconstructions. In Chapter V, we discuss exact and fast Fourier-domain reconstruction algorithms for TAT in planar and circular configurations.

京都大学 / 0048 / 新制・課程博士 / 博士(人間健康科学) / 甲第21037号 / 人健博第53号 / 新制||人健||4(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 杉本 直三, 教授 精山 明敏, 教授 安達 泰治 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DFAM

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