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Comparing Immune Responses to Inactivated Vaccines Against SARS-CoV-2 Between People Living With HIV and HIV-Negative Individuals: A Cross-Sectional Study in ChinaHuang, Xiaojie, Yan, Ying, Su, Bin, Xiao, Dong, Yu, Maohe, Jin, Xia, Duan, Junyi, Zhang, Xiangjun, Zheng, Shimin, Fang, Yuan, Zhang, Tong, Tang, Weiming, Wang, Lunan, Wang, Zixin, Xu, Junjie 28 January 2022 (has links)
This study compared the immunogenicity of inactivated SARS-CoV-2 vaccines between people living with HIV (PLWH) and HIV-negative individuals. We recruited 120 PLWH and 53 HIV-negative individuals aged 18-59 years who had received an inactivated SARS-CoV-2 vaccine in two Chinese cities between April and June 2021. Blood samples were tested for immunogenicity of the inactivated SARS-CoV-2 vaccines. The prevalence and severity of adverse events associated with SARS-CoV-2 vaccines were similar between PLWH and HIV-negative individuals. The seropositivity of neutralizing activity against authentic SARS-CoV-2, of the total amount of antibody (total antibody) and of S-IgG were 71.3%, 81.9%, and 92.6%, respectively, among fully vaccinated PLWH. Among all participants, PLWH had lower neutralizing activity, total antibody, S-IgG, and T-cell-specific immune response levels, compared to HIV-negative individuals, after controlling for types of vaccine, time interval between first and second dose, time after receiving the second dose, and sociodemographic factors. PLWH with a longer interval since HIV diagnosis, who received their second dose 15-28 days prior to study commencement, and who had an interval of ≥21 days between first and second dose had higher neutralizing activity levels. The immunogenicity of the inactivated SARS-CoV-2 vaccines was lower among PLWH as compared to HIV-negative individuals. Vaccination guideline specific for PLWH should be developed.
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The evaluation of the implementation of HIV-AIDS policies at school level with particular focus on discrimination and stigma amongst educatorsMokwatlo, Elizabeth Maboakae 30 June 2006 (has links)
Against the background of evidence that HIV-AIDS has had and continues to have
an enormous impact on all South African schools, a need has arisen for HIV -AIDS
policies and programmes to be effectively implemented in all schools. In this study, a
qualitative methodology was used to evaluate policy implementation in the North
West province. Data was gathered by means of field notes, observation and
interviews with management and educators. The study found that although principals
and educators are knowledgeable about HIV -AIDS, there is a tendency to
discriminate against infected educators, particularly in terms of educator workload.
This study also revealed that educators fear being accidentally exposed to HIV -AIDS
infected blood, despite the guidelines given in the National HIV -AIDS policy and the
availability of emergency first aid kits. The key thought emerging from this study is
that not all schools are able to deal effectively with HIV -AIDS and that schools
urgently need to plan or implement their own policies in this regard. School-based
HIV-AIDS policies can only be successful if they take cognisance of local contextual
issues and involve the three spheres of influence in the lives of educators and
learners, namely, the sphere of the school, the sphere of family life and the sphere of
the community. / Sociology / M.A.(Social and Behavioural Studies in HIV-AIDS)
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The evaluation of the implementation of HIV-AIDS policies at school level with particular focus on discrimination and stigma amongst educatorsMokwatlo, Elizabeth Maboakae 30 June 2006 (has links)
Against the background of evidence that HIV-AIDS has had and continues to have
an enormous impact on all South African schools, a need has arisen for HIV -AIDS
policies and programmes to be effectively implemented in all schools. In this study, a
qualitative methodology was used to evaluate policy implementation in the North
West province. Data was gathered by means of field notes, observation and
interviews with management and educators. The study found that although principals
and educators are knowledgeable about HIV -AIDS, there is a tendency to
discriminate against infected educators, particularly in terms of educator workload.
This study also revealed that educators fear being accidentally exposed to HIV -AIDS
infected blood, despite the guidelines given in the National HIV -AIDS policy and the
availability of emergency first aid kits. The key thought emerging from this study is
that not all schools are able to deal effectively with HIV -AIDS and that schools
urgently need to plan or implement their own policies in this regard. School-based
HIV-AIDS policies can only be successful if they take cognisance of local contextual
issues and involve the three spheres of influence in the lives of educators and
learners, namely, the sphere of the school, the sphere of family life and the sphere of
the community. / Sociology / M.A.(Social and Behavioural Studies in HIV-AIDS)
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