Most Small and Medium scale Enterprises (SMEs) in Ghana are notparticularly anxious about the consequences of inadequacy or lack of anyform of vulnerability management operation in their normal businesspractices. This case study research explores how a local Internet ServiceProvider (ISP) in Ghana and its local client-base can manage vulnerabilitieswith a targeted patch management practise integrated into their operations.To answer the research question “How can a SME local Internet ServiceProvider (ISP) in Accra, Ghana, assist their local customer base to integrateeffective cybersecurity vulnerability management into their operations?“,This case study comprised the Subject Matter Expert of one local ISP as well as4 other technical Subject Matter Experts of the ISP’s clients about their patchmanagement operations. This case study research revealed that most SMEs donot consider vulnerability management as a key concern in the operation oftheir organisation and therefore, proposes a way to highlight the importanceof vulnerability management whiles doing so at a cost-effective manner. Theimplications of targeted cybersecurity patch management for the local ISP andtheir client-base is also addressed by this thesis research.