No description available.

A study was made of the effects of diphenylhydantoin (DPH) and the carrier solution on the spleen, lymph node, and thymus. DPH was injected i.p. at concentrations of 5 and 10 mg./100 gm. for 30 and 60 days. Hematologic effects observed were leucocytosis, neutrophilia, eosinophilia, and lymphopenia. Respiratory measurements of lymph node tissue slices were made using the oxygen electrode method. The carrier solution was found to cause a marked increase in oxygen consumption. A DPH effect on lymph tissue respiration was not observed. The carrier alone caused an atrophy of the lymph nodes and thymus, as well as an increase in the total body weight. Histological examination revealed that the 5 mg./100 gm. DPH injected for 60 days and the 10 mg./100 gm. DPH injected for 30 or 60 days produced a histiocytic cell type lymphoma, resembling Hodgkin's disease in the lymph node, thymus, and spleen in rats. The data indicated that DPH may not be a direct carcinogen, but it may interfere with the normal immune mechanism to produce the changes observed.

No description available.

No description available.

No description available.

Research into the cause of autism continues without any clear-cut answers. However, recent studies suggest that abnormalities of the immune system are associated with this disorder and autism results from failure of the immune system to regulate itself. Proper immune regulation requires that the host have the appropriate number and percentage of each population of lymphocytes and monocytes. These populations can be distinguished from one another with monoclonal antibodies that react with unique protein structures on the cell surface designated as the "cluster of differentiation" (CD) antigens. This investigation studied the possibility that the immune abnormalities seen in autism are due to a change in the lymphocytes or monocytes in the subjects with autism . The autistic subjects as compared to age- and sex-matched control subjects exhibited several changes in their cell populations. These included a depression of total lymphocytes, CD2+ (total T cells), CD4+ (helper T cells), and CD4+CD45RA+ (the antigen-inexperienced, suppressor inducer subset of helper T cells). Also analyzed were the siblings of the autistic subjects. A reduced percentage of CD4+ cells was seen in the male siblings as compared to unrelated males. Analyses also compared the cells of mothers and fathers of the autistic subjects with controls of mothers and fathers of normal children. No differences were seen in any of the markers used. Findings in the literature show an increase in memory cells and a decrease in naive cells as a function of age. The data gathered in these experiments uphold this concept and are consistent with the idea that CD45RA and CDw29 are maturational states of helper T cells. The quantitation of different immune markers on lymphoid cells seems to have been useful in the further characterization and investigation of the immune mechanism relevant to the syndrome of autism. Differences in some of the cell types were observed and may account for some of the immune abnormalities seen in autism. These differences may be the result or the cause of the syndrome. Further investigation seems necessary before a direct pathological link can be found between the body's immunity and autism.

No description available.

No description available.

Es tracta d'un estudi epidemiològic de les neoplàsies limfoides a Tarragona. Es donen dades d'incidència, mortalitat, supervivència i prevalença en base poblacional de les 3.258 neoplàsies limfoides del Registre de Càncer de Tarragona durant el període 1980-2004 ( 354 limfomes de Hodgkin, 1605 limfomes no-Hodgkin (LNH), 676 mielomes múltiples, 188 leucèmies limfàtiques agudes i 435 leucèmies limfàtiques cròniques). S'ha estudiat la tendència temporal de la incidència i la seva projecció a 2010 i 2015 per a cada grup de malalties. Els LNH s'han classificat histològicament d'acord amb la classificació de l'OMS de les neoplàsies hematològiques, i s'han establert comparacions internacionals. Les principals conclusions han estat que les neoplàsies limfoides a Tarragona mostren un patró epidemiològic occidentalitzat, amb una progressiva millora en la seva supervivència relativa, i que existeix, almenys parcialment, una relació temporal entre la epidèmia de la SIDA i la dels LNH. / This is an epidemiological study of lymphoid neoplasms in Tarragona, a southern region of Catalonia with a population over 800.000. It gives details of incidence, mortality, survival and prevalence in a population basis of 3,258 lymphoid malignancies recorded in the Tarragona Cancer Registry during the period 1980 to 2004 (354 Hodgkin's lymphoma, 1605 non-Hodgkin's lymphoma (NHL), 676 multiple myeloma, 188 acute lymphocytic leukemia and 435 chronic lymphocytic leukemia). We have studied the incidence time trend and its projection to 2010 and 2015 for each disease group. The NHL were classified histologically according to WHO classification of hematologic malignancies, and their relative frequency were compared internationally. The main conclusions were that the lymphoid malignancies in Tarragona show a westernized epidemiological pattern, with a progressive improvement in their relative survival and that there is at least partially, a temporal relationship between the AIDS and the NHL epidemics.

Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1998. / Erratum is pasted onto back end-paper. Bibliography: leaves 164-207.