Introdução: O carcinoma espinocelular (CEC) representa 7% de todos os novos casos de câncer no mundo, sendo o carcinoma espinocelular o tipo mais frequente. Tanto o comportamento biológico quanto o crescimento dos tumores devem ser melhores entendidos, uma vez que a sobrevida dos pacientes apresentou discreta melhora nas últimas décadas. Os modelos PDX foram desenvolvidos para estudar a biologia tumoral e principalmente os mecanismos de crescimento e proliferação através da manutenção da arquitetura e microambiente tumoral do tumor original. Os retinóides possuem a capacidade de restaurar o crescimento e a diferenciação de células normais através da ação dos receptores retinóides nucleares (RARs e RXRs) que são os principais mediadores destas ações que ao sofrerem alterações na sua expressão podem levar ao desenvolvimento e manutenção de tumores. No estudo da carcinogênese o modelo PDX é uma importante ferramenta pois mantém a arquitetura e microambiente do tumor original melhorando a compreensão de algumas vias, entre estas o processo de EMT/MET, na diferenciação das células tronco tumorais e quais receptores nucleares podem estar influenciando nestas vias. Objetivos: Analisar os padrões de comportamento biológico - tempo de formação e expansão do tumor e a manutenção dos padrões histológicos e de arquitetura do tumor original - em F0 e F1 no modelo PDX (xenoenxerto derivado de paciente) das amostras de centro de tumor e epitélio adjacente em camundongos Balb C/nude e avaliar a expressão gênica dos receptores retinóides, ALDH1 e marcadores do processo de EMT/MET por RT-PCR em PDX de carcinoma espinocelular oral em comparação com a amostra dos pacientes doadores nas passagens F(0) e F(1). Método: 24 camundongos Balb C/Nude, divididos em 2 grupos TG(I) – tumor graft paciente (I) e TG(II) – tumor graft paciente (II), subdivididos em 4 grupos de 3 animais: (A) – receberam PDX do centro do tumor; (B) – receberam PDX de epitélio adjacente ao tumor (margem de segurança cirúrgica); (C) receberam PDX de um animal do grupo (A); (D) receberam PDX de um animal do grupo (B). E Após estas fases, as amostras coletadas serão avaliadas por RT-PCR para comparação das expressões gênicas entre a amostra original (CT e EA) com os PDX´s nas passagens F(0) e F(1). Resultados: formação de tumores em todos os grupos – tanto do PDX de fragmento de centro do tumor quanto do PDX do epitélio adjacente. E A expressão gênica dos parâmetros observados não diferem no tumor original e passagem F(0) significativamente diferentes em F(1) (p<0,05). Conclusões: A técnida do PDX para o CEC é possível de ser realizada em menor tempo com a implantação de apenas um fragmento do tumor. Os tumores resultantes do PDX apresentaram tamanho suficiente para novas passagens, bem como para seu 6 uso em estudos de comportamento biológico das células neoplásicas. Quanto ao epitélio adjacente ao tumor (margem de segurança cirúrgica) constatou-se a presença de células tumorais com potencial de promover o crescimento de tumores devendo portanto ser melhor observada nas ressecções. O PDX de primeira passagem F(0) é o que mais se assemelha com o tumor original sendo o melhor para testes terapêuticos e estudos da carcinogênese do CEC oral. Keywords: CECP, modelo PDX, xenoenxerto, margem de segurança cirúrgica, , receptores retinóides, microdissecção a laser. / Introduction: Squamous cell carcinoma (SCC) represents 7% of all new cases of cancer in the world, with squamous cell carcinoma being the most frequent type. Both the biological behavior and the growth of the patients should be better understood, since the patients' survival show unobtrusive improvement in the last decades. PDX models were developed to study a tumor biology and especially the mechanisms of growth and proliferation through maintenance of the architecture and tumor microenvironment of the original tumor. Retinoids have a capacity to restore normal cell growth and differentiation through the action of nuclear retinoid receptors (RARs and RXRs) that are the main mediators and maintenance actions of tumors. In the study of carcinogenesis, the PDX model is an important tool because it maintains an architecture and microenvironment of the original tumor, improving an understanding of some pathways, among them in the EMT / MET process, the difference in tumor stem cells and which nuclear receptors may be influencing these routes. Objectives: To analyze changes in methodology and patterns of biological behavior - time of tumor formation and expansion and maintenance of histological and architectural patterns of the original tumor - in F0 and F1 without PDX model (patient derived xenograft) tumor and adjacent epithelium in Balb C / nude mice and to evaluate the gene expression of retinoid receptors, ALDH1 and EMT / MET process markers by RT-PCR in PDX of oral squamous cell carcinoma compared to a sample of donor patients in F ( 0) and F (1). Method: 24 Balb C / Nude mice, divided into 2 groups TG (I) - patient tumor graft (I) and TG (II) - patient tumor graft (II) subdivided into 4 groups of 3 animals: (A) - received PDX from the center of the tumor; (B) - received epithelial PDX adjacent to the tumor (surgical margin of safety); (C) received PDX from one animal of group (A); (D) received PDX from one animal of group (B). E After these phases, as samples collected for RT-PCR evaluation for comparison of gene expressions between an original sample (CT and EA) with F passages of PDX F (0) and F (1). Results: tumor formation in all groups - both the PDX of the tumor center fragment and the PDX of the adjacent epithelium. E The gene expression of the observed parameters did not differ without original tumor and F (0) differential passage in F (1) (p <0.05). Conclusions: The PDX technique for CPB is possible to be performed in a shorter time with a tumor fragment implantation. Tumors resulting from PDX presented the solution for new passages, as well as for their use in studies of the biological behavior of neoplastic cells. As for the epithelium adjacent to the tumor (surgical margin of safety), a presence of tumor cells with the potential to promote the growth of tumors has been observed and should therefore be better observed in the resections. The first pass PDX F (0) is the one that most closely resembles the 8 original tumor being the best for therapeutic tests and studies of oral SCC carcinogenesis.

Introdução: O carcinoma espinocelular (CEC) representa 7% de todos os novos casos de câncer no mundo, sendo o carcinoma espinocelular o tipo mais frequente. Tanto o comportamento biológico quanto o crescimento dos tumores devem ser melhores entendidos, uma vez que a sobrevida dos pacientes apresentou discreta melhora nas últimas décadas. Os modelos PDX foram desenvolvidos para estudar a biologia tumoral e principalmente os mecanismos de crescimento e proliferação através da manutenção da arquitetura e microambiente tumoral do tumor original. Os retinóides possuem a capacidade de restaurar o crescimento e a diferenciação de células normais através da ação dos receptores retinóides nucleares (RARs e RXRs) que são os principais mediadores destas ações que ao sofrerem alterações na sua expressão podem levar ao desenvolvimento e manutenção de tumores. No estudo da carcinogênese o modelo PDX é uma importante ferramenta pois mantém a arquitetura e microambiente do tumor original melhorando a compreensão de algumas vias, entre estas o processo de EMT/MET, na diferenciação das células tronco tumorais e quais receptores nucleares podem estar influenciando nestas vias. Objetivos: Analisar os padrões de comportamento biológico - tempo de formação e expansão do tumor e a manutenção dos padrões histológicos e de arquitetura do tumor original - em F0 e F1 no modelo PDX (xenoenxerto derivado de paciente) das amostras de centro de tumor e epitélio adjacente em camundongos Balb C/nude e avaliar a expressão gênica dos receptores retinóides, ALDH1 e marcadores do processo de EMT/MET por RT-PCR em PDX de carcinoma espinocelular oral em comparação com a amostra dos pacientes doadores nas passagens F(0) e F(1). Método: 24 camundongos Balb C/Nude, divididos em 2 grupos TG(I) – tumor graft paciente (I) e TG(II) – tumor graft paciente (II), subdivididos em 4 grupos de 3 animais: (A) – receberam PDX do centro do tumor; (B) – receberam PDX de epitélio adjacente ao tumor (margem de segurança cirúrgica); (C) receberam PDX de um animal do grupo (A); (D) receberam PDX de um animal do grupo (B). E Após estas fases, as amostras coletadas serão avaliadas por RT-PCR para comparação das expressões gênicas entre a amostra original (CT e EA) com os PDX´s nas passagens F(0) e F(1). Resultados: formação de tumores em todos os grupos – tanto do PDX de fragmento de centro do tumor quanto do PDX do epitélio adjacente. E A expressão gênica dos parâmetros observados não diferem no tumor original e passagem F(0) significativamente diferentes em F(1) (p<0,05). Conclusões: A técnida do PDX para o CEC é possível de ser realizada em menor tempo com a implantação de apenas um fragmento do tumor. Os tumores resultantes do PDX apresentaram tamanho suficiente para novas passagens, bem como para seu 6 uso em estudos de comportamento biológico das células neoplásicas. Quanto ao epitélio adjacente ao tumor (margem de segurança cirúrgica) constatou-se a presença de células tumorais com potencial de promover o crescimento de tumores devendo portanto ser melhor observada nas ressecções. O PDX de primeira passagem F(0) é o que mais se assemelha com o tumor original sendo o melhor para testes terapêuticos e estudos da carcinogênese do CEC oral. Keywords: CECP, modelo PDX, xenoenxerto, margem de segurança cirúrgica, , receptores retinóides, microdissecção a laser. / Introduction: Squamous cell carcinoma (SCC) represents 7% of all new cases of cancer in the world, with squamous cell carcinoma being the most frequent type. Both the biological behavior and the growth of the patients should be better understood, since the patients' survival show unobtrusive improvement in the last decades. PDX models were developed to study a tumor biology and especially the mechanisms of growth and proliferation through maintenance of the architecture and tumor microenvironment of the original tumor. Retinoids have a capacity to restore normal cell growth and differentiation through the action of nuclear retinoid receptors (RARs and RXRs) that are the main mediators and maintenance actions of tumors. In the study of carcinogenesis, the PDX model is an important tool because it maintains an architecture and microenvironment of the original tumor, improving an understanding of some pathways, among them in the EMT / MET process, the difference in tumor stem cells and which nuclear receptors may be influencing these routes. Objectives: To analyze changes in methodology and patterns of biological behavior - time of tumor formation and expansion and maintenance of histological and architectural patterns of the original tumor - in F0 and F1 without PDX model (patient derived xenograft) tumor and adjacent epithelium in Balb C / nude mice and to evaluate the gene expression of retinoid receptors, ALDH1 and EMT / MET process markers by RT-PCR in PDX of oral squamous cell carcinoma compared to a sample of donor patients in F ( 0) and F (1). Method: 24 Balb C / Nude mice, divided into 2 groups TG (I) - patient tumor graft (I) and TG (II) - patient tumor graft (II) subdivided into 4 groups of 3 animals: (A) - received PDX from the center of the tumor; (B) - received epithelial PDX adjacent to the tumor (surgical margin of safety); (C) received PDX from one animal of group (A); (D) received PDX from one animal of group (B). E After these phases, as samples collected for RT-PCR evaluation for comparison of gene expressions between an original sample (CT and EA) with F passages of PDX F (0) and F (1). Results: tumor formation in all groups - both the PDX of the tumor center fragment and the PDX of the adjacent epithelium. E The gene expression of the observed parameters did not differ without original tumor and F (0) differential passage in F (1) (p <0.05). Conclusions: The PDX technique for CPB is possible to be performed in a shorter time with a tumor fragment implantation. Tumors resulting from PDX presented the solution for new passages, as well as for their use in studies of the biological behavior of neoplastic cells. As for the epithelium adjacent to the tumor (surgical margin of safety), a presence of tumor cells with the potential to promote the growth of tumors has been observed and should therefore be better observed in the resections. The first pass PDX F (0) is the one that most closely resembles the 8 original tumor being the best for therapeutic tests and studies of oral SCC carcinogenesis.

Introdução: O carcinoma espinocelular (CEC) representa 7% de todos os novos casos de câncer no mundo, sendo o carcinoma espinocelular o tipo mais frequente. Tanto o comportamento biológico quanto o crescimento dos tumores devem ser melhores entendidos, uma vez que a sobrevida dos pacientes apresentou discreta melhora nas últimas décadas. Os modelos PDX foram desenvolvidos para estudar a biologia tumoral e principalmente os mecanismos de crescimento e proliferação através da manutenção da arquitetura e microambiente tumoral do tumor original. Os retinóides possuem a capacidade de restaurar o crescimento e a diferenciação de células normais através da ação dos receptores retinóides nucleares (RARs e RXRs) que são os principais mediadores destas ações que ao sofrerem alterações na sua expressão podem levar ao desenvolvimento e manutenção de tumores. No estudo da carcinogênese o modelo PDX é uma importante ferramenta pois mantém a arquitetura e microambiente do tumor original melhorando a compreensão de algumas vias, entre estas o processo de EMT/MET, na diferenciação das células tronco tumorais e quais receptores nucleares podem estar influenciando nestas vias. Objetivos: Analisar os padrões de comportamento biológico - tempo de formação e expansão do tumor e a manutenção dos padrões histológicos e de arquitetura do tumor original - em F0 e F1 no modelo PDX (xenoenxerto derivado de paciente) das amostras de centro de tumor e epitélio adjacente em camundongos Balb C/nude e avaliar a expressão gênica dos receptores retinóides, ALDH1 e marcadores do processo de EMT/MET por RT-PCR em PDX de carcinoma espinocelular oral em comparação com a amostra dos pacientes doadores nas passagens F(0) e F(1). Método: 24 camundongos Balb C/Nude, divididos em 2 grupos TG(I) – tumor graft paciente (I) e TG(II) – tumor graft paciente (II), subdivididos em 4 grupos de 3 animais: (A) – receberam PDX do centro do tumor; (B) – receberam PDX de epitélio adjacente ao tumor (margem de segurança cirúrgica); (C) receberam PDX de um animal do grupo (A); (D) receberam PDX de um animal do grupo (B). E Após estas fases, as amostras coletadas serão avaliadas por RT-PCR para comparação das expressões gênicas entre a amostra original (CT e EA) com os PDX´s nas passagens F(0) e F(1). Resultados: formação de tumores em todos os grupos – tanto do PDX de fragmento de centro do tumor quanto do PDX do epitélio adjacente. E A expressão gênica dos parâmetros observados não diferem no tumor original e passagem F(0) significativamente diferentes em F(1) (p<0,05). Conclusões: A técnida do PDX para o CEC é possível de ser realizada em menor tempo com a implantação de apenas um fragmento do tumor. Os tumores resultantes do PDX apresentaram tamanho suficiente para novas passagens, bem como para seu 6 uso em estudos de comportamento biológico das células neoplásicas. Quanto ao epitélio adjacente ao tumor (margem de segurança cirúrgica) constatou-se a presença de células tumorais com potencial de promover o crescimento de tumores devendo portanto ser melhor observada nas ressecções. O PDX de primeira passagem F(0) é o que mais se assemelha com o tumor original sendo o melhor para testes terapêuticos e estudos da carcinogênese do CEC oral. Keywords: CECP, modelo PDX, xenoenxerto, margem de segurança cirúrgica, , receptores retinóides, microdissecção a laser. / Introduction: Squamous cell carcinoma (SCC) represents 7% of all new cases of cancer in the world, with squamous cell carcinoma being the most frequent type. Both the biological behavior and the growth of the patients should be better understood, since the patients' survival show unobtrusive improvement in the last decades. PDX models were developed to study a tumor biology and especially the mechanisms of growth and proliferation through maintenance of the architecture and tumor microenvironment of the original tumor. Retinoids have a capacity to restore normal cell growth and differentiation through the action of nuclear retinoid receptors (RARs and RXRs) that are the main mediators and maintenance actions of tumors. In the study of carcinogenesis, the PDX model is an important tool because it maintains an architecture and microenvironment of the original tumor, improving an understanding of some pathways, among them in the EMT / MET process, the difference in tumor stem cells and which nuclear receptors may be influencing these routes. Objectives: To analyze changes in methodology and patterns of biological behavior - time of tumor formation and expansion and maintenance of histological and architectural patterns of the original tumor - in F0 and F1 without PDX model (patient derived xenograft) tumor and adjacent epithelium in Balb C / nude mice and to evaluate the gene expression of retinoid receptors, ALDH1 and EMT / MET process markers by RT-PCR in PDX of oral squamous cell carcinoma compared to a sample of donor patients in F ( 0) and F (1). Method: 24 Balb C / Nude mice, divided into 2 groups TG (I) - patient tumor graft (I) and TG (II) - patient tumor graft (II) subdivided into 4 groups of 3 animals: (A) - received PDX from the center of the tumor; (B) - received epithelial PDX adjacent to the tumor (surgical margin of safety); (C) received PDX from one animal of group (A); (D) received PDX from one animal of group (B). E After these phases, as samples collected for RT-PCR evaluation for comparison of gene expressions between an original sample (CT and EA) with F passages of PDX F (0) and F (1). Results: tumor formation in all groups - both the PDX of the tumor center fragment and the PDX of the adjacent epithelium. E The gene expression of the observed parameters did not differ without original tumor and F (0) differential passage in F (1) (p <0.05). Conclusions: The PDX technique for CPB is possible to be performed in a shorter time with a tumor fragment implantation. Tumors resulting from PDX presented the solution for new passages, as well as for their use in studies of the biological behavior of neoplastic cells. As for the epithelium adjacent to the tumor (surgical margin of safety), a presence of tumor cells with the potential to promote the growth of tumors has been observed and should therefore be better observed in the resections. The first pass PDX F (0) is the one that most closely resembles the 8 original tumor being the best for therapeutic tests and studies of oral SCC carcinogenesis.

A distributed approach can improve functionality of H/WQ (Hydrology and Water Quality) modeling by facilitating a way to explicitly incorporate spatial characteristics of a watershed into the model. The time-area approach, with its intuitive and inherently distributed concept, provides a simple method to simulate runoff mechanisms. This study developed a distributed model based on the time-area approach with the goal of improved utility and efficiency in H/WQ modeling. Uncertainty is always introduced into watershed modeling because of imperfect knowledge and scale dependant spatial heterogeneity and temporal variability. Uncertainty analysis can provide a modeler, policy maker, and stakeholder with reliability information, better understanding, and better communication about the modeling results. This study quantified uncertainty of the model parameter and output through uncertainty analysis in order to assess risk in watershed management. The main goal of this study was to develop a hydrology and sediment transport model capable of routing overland flow using a time-area concept and providing reliability of the modeling results in a probabilistic manner through uncertainty analysis. The HYSTAR (HYdrology and Sediment transport simulation using Time-ARea method) model incorporates a modified Curve Number (CN) method and the newly devised time-area routing method to estimate runoff. HYSTAR is capable of simulating direct runoff, base flow, soil moisture, and sediment load in a distributed manner and in an hourly time step. In the model, the modified CN and a continuity equation are used to calculate infiltration of the routed runoff as well as rainfall on every overland cell. The effective direct runoff volume is distributed over downstream areas using the newly developed routing method. A direct runoff hydrograph is constructed directly through the discrete convolution of the time-area histogram and the effective direct runoff volume map without employing a unit hydrograph. In addition, sediment transport is simulated using the routing method and the sediment transport capacity approach without using a delivery ratio. The sensitivity analysis found that the CN and root zone depth were the most critical parameters for runoff simulation with HYSTAR. The model provided acceptable performance in predicting runoff and sediment load of a subwatershed of the Owl Run Watershed (ORD) with the Nash-Sutcliffe efficiency coefficient and coefficient of determination greater than 0.5. However, it failed to reproduce runoff for a subwatershed of Polecat Creek Watershed (PCA), where data show that runoff is not immediately responsive to rainfall. Uncertainty analysis revealed that the confidence intervals of the simulated monthly runoff and sediment load corresponded to 9.7 % and 10.2 % of their averages, respectively, at a significance level of 0.05. In addition, the average ranges of variation created by the Digital Elevation Model (DEM) and National Land Cover Data (NLCD) errors in the simulated monthly runoff and sediment load were equivalent to 7.5 % and 15.9 % of the average of their calibrated values, respectively. Based on the uncertainty analysis results, the Margin of Safety (MOS) of Total Maximum Daily Load (TMDL) were explicitly quantified as corresponding to 7.0 % and 21.3 % of the average of the simulated runoff and sediment load for ORD at significance level of 0.05. In conclusion, the HYSTAR model provided a new way to explicitly simulate runoff and sediment load of a watershed in a distributed manner. The approach developed here retains the simplicity of a unit hydrograph approach without employing numerical methods. Uncertainty analysis found that parameter uncertainty had greater impact on the model output than did expected Geographic Information System (GIS) data errors. In addition, the impact of the topographic data error on the model output was greater than was that of the land cover data error. Finally, this study provided a proof that a 5 to 10 % MOS that many TMDL studies consider underestimates modeling uncertainty. / Ph. D.

Indiana University-Purdue University Indianapolis (IUPUI) / In a multifidelity structural design process, depending on the required analysis, different levels of structural models are needed. Within the aerospace design, analysis and optimization community, there is an increasing demand for automatic generation of parametric feature tree (build recipe) attributed multidisciplinary models. Currently, this is mainly done by creating separate models for different disciplines such as mid-surface model for aeroelasticity, outer-mold line for aerodynamics and CFD, and built-up element model for structural analysis. Since all of these models are built independently, any changes in design parameters require updates on all the models which is inefficient, time-consuming and prone to deficiencies. In this research, Engineering Sketch Pad (ESP) is used to create attribution and maintain consistency between structural models with different fidelity levels. It provides the user with the ability to interact with a configuration by building and/or modifying the design parameters and feature tree that define the configuration. ESP is based an open-source constructive solid modeler, named OpenCSM, which is built upon the OpenCASCADE geometry kernel and the EGADS geometry generation system. The use of OpenCSM as part of the AFRL’s CAPS project on Computational Aircraft Prototype Syntheses for automatic commercial and fighter jet models is demonstrated. The rapid generation of parametric aircraft structural models proposed and developed in this work will benefit the aerospace industry with coming up with efficient, fast and robust multidisciplinary design standardization of aircraft structures. Metallic aircraft wings are usually not optimized to their fullest potential due to shortage of development time. With roughly \$1000 worth of potential fuel savings per pound of weight reduction over the operational life of an aircraft, airlines are trying to minimize the weight of aircraft structures. A stiffness based strategy is used to map the nodal data of the lower-order fidelity structural models onto the higher-order ones. A simple multi-fidelity analysis process for a parametric wing is used to demonstrate the advantage of the approach. The loads on the wing are applied from a stick model as is done in the industry. C program is created to connect the parametric design software ESP, analysis software Nastran, load file and design configuration file in CSV format. This problem gets compounded when it comes to optimization of composite wings. In this study, a multi-level optimization strategy to optimize the weight of a composite transport aircraft wing is proposed. The part is assumed to initially have some arbitrary number of composite super plies. Super plies are a concept consisting of a set of plies all arranged in the same direction. The thickness and orientation angles of the super plies are optimized. Then, each ply undergoes topometry optimization to obtain the areas of each super ply taking the least load so that it could be cut and removed. Each of the super plies are then optimized for the thickness and orientation angles of the sub plies. The work presented on this paper is part of a project done for Air Force Research Laboratory (AFRL) connecting the parametric geometry modeler (ESP) with the finite element solver (Nastran).

Pelningumo siekimas yra pagrindinis verslo įmonės tikslas, dažnai lemiantis vadovų pasirinkimą sprendžiant problemas susijusias su pardavimo kainomis, įvairiomis išlaidomis. Pelno-išlaidų-veiklos apimties vertinimas teikia apibendrinantį planavimo proceso vaizdą ir išlaidų kitimo supratimą, todėl gauta informacija yra nepakeičiama, siekiant užtikrinti racionalų įmonės valdymą. Šio darbo tikslas – išanalizavus pelno-išlaidų-veiklos apimties metodologiją, atlikti įmonės pelno-išlaidų-veiklos apimties vertinimą ir sudaryti modelį, leidžiantį efektyviai planuoti ir analizuoti įmonės kaštų, veiklos apimties ir pelno ryšį. Taigi, šio darbo objektas-įmonės pelningumas, jo priklausomybė nuo įmonės pajamų, kaštų ir veiklos apimties. Siekiant įgyvendinti darbo tikslą, keliami tokie uždaviniai: išanalizuoti pelno-išlaidų-veiklos apimties vertinimo metodologiją, suformuoti prielaidas pelno-išlaidų-veiklos apimties vertinimo modeliavimui, atlikti įmonės pelno-išlaidų-veiklos apimties vertinimą, bei sudaryti pelno-išlaidų-veiklos apimties vertinimo modelį. Darbą sudaro trys pagrindinės dalys: metodologinė, analitinė ir rezultatų. Pirmojoje darbo dalyje nagrinėjami pelno-išlaidų-veiklos apimties vertinimo metodologijos aspektai-pateikiamos analizės prielaidos, vertinimo reikšmė ir galimybės. Antrasis darbo skyrius apima prielaidų pelno-išlaidų-veiklos apimties vertinimo modeliavimui analizę: tiriami ir lyginami pelno-išlaidų-veiklos apimties vertinimo modeliavimo metodai, bei pateikiama... [toliau žr. visą tekstą] / The main purpose of business enterprise is striving for profitability and this purpose usually decides the head‘s of enterprise choice when he tackles the problems about prices of sales and different expenses. Cost-volume-profit evaluation gives resumptive view about planning process and understanding of costs range so given information is irreplaceable because of trying to ensure rational management. The purpose of this work is to do cost-volume-profit evaluation and make a model according the analysis of cost-volume-profit methodology. This model will let to plan and analyse enterprise‘s cost, activity‘s size and profit‘s relation in effective way. So the object of this work is the profitability of an enterprise, its dependence from enterprises revenue, cost and activity‘s volume. In purpose to realize work‘s aim there are these objectives: to analyse cost-volume-profit evaluation methodology, to structure presumptions for cost-volume-profit evaluation modeling, to do enterprises cost-volume-profit evaluation and to make cost-volume-profit evaluation model. Three main parts makes this work: methodological, analytical, results. In the first part of this work there is an analyses of cost-volume-profit evaluation methodology‘s aspects, there are analysis presumptions, evaluations mean and possibilities. The second part includes presumptions analysis to cost-volume-profit evaluation modeling: here are researched and compared cost-volume-profit evaluation modeling methods and is... [to full text]