Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Barbora Šmídová Supervisor: Prof. MUDr. Jaroslav Dršata, CSc. Supervisor - specialist: RNDr. Mgr. Alena Tichá, PhD. Title of diploma thesis: CHANGES OF LIPID SPECTRUM DURING BODY MASS REDUCTION IN PATIENTS WITH DIABETES MELLITUS The thesis deals with the determination of lipid parameters (plasma total fatty acids, plasma total cholesterol, lipoprotein cholesterol, plasma triglycerides, plasma cholesterol precursors (lathosterol and squalene) and markers of cholesterol absorption (β-sitosterol and campesterol)) in obese patiens with diabetes mellitus type 1 and type 2 who were tested with a seven-day fasting, followed by low-calorie diabetic diet. It is assumed that weight loss should improve insulin resistence. The aim of this work is to evaluate the lipid parameters during the body weight reduction in obese patients suffering with diabetes mellitus. Lipids were determined before and after a seven-day fasting and after one month from the beginning of fasting (in patiens with diabetes mellitus type 1 also after one year). Gas chromatography was used for the determination of fatty acids and non-cholesterol sterols and squalene. Cholesterol and triglycerides were determined by a routine...

This thesis deals with the numerical analysis state of stress diesel engine piston. Based on results of performed analyses a new pistons designed with a focus on mass reduction and consequently individual structural designs are compared with present piston.

O que se desejou investigar é se a metodologia do Design Thinking (DT) e da Teoria de Resolução de Problemas Inventivos (TRIZ) podem ser utilizadas em conjunto de maneira sinérgica na fase conceitual de um processo de desenvolvimento de produto (PDP) automotivo do tipo APQP (Advanced Product Quality Planning) com a finalidade de alavancar a criatividade na geração de ideias e, ao mesmo tempo, selecionar o melhor conceito para levar às demais fases do PDP. A presente pesquisa busca entender dentro da literatura os pontos fortes e limitações de cada uma das metodologias e, ao mesmo tempo, propõe uma forma de combiná-las à metodologia APQP. O processo proposto é então testado dentro de um projeto de redução de massa de guarnição de carroceria na região da porta de um veículo automotivo de passeio. Como ficará demonstrado, o PDP automotivo do tipo APQP, utilizando a melhoria proposta, se mostra mais eficaz ao alavancar a criatividade ao mesmo tempo que consolida uma fase de conceito dentro do APQP automotivo tradicional. Através desta pesquisa, concluiu-se que ambas as metodologias são sinérgicas e que, portanto, podem trazer melhorias para o atual processo APQP, alavancando a qualidade e assertividade da geração de ideias, bem como apoiando a seleção do melhor conceito a ser levado para as próximas fases. / This research aimed to verify whether the methodology of Design Thinking (DT) and the Theory of Inventive Problem Solving (TRIZ) could be used together synergistically in the conceptual phase of a new product development project (NPD) in the automotive industry through the also know APQP (Advanced Product Quality Planning) process. The main purpose was to leverage the creativity by generating ideas that are more qualified and, at the same time, select the best product concepts to be taken to the next phases of the NPD. This research seeks to understand within the literature the strengths and limitations of each of the methodologies and, at the same time, a proposal is made on how to integrate them into the APQP methodology. The proposed process is then tested in a project of mass reduction of the door body seal of an automotive vehicle. As shall be demonstrated, the automotive NPD, by using the improvement proposal, will become more effective by leveraging the creativity while consolidates a conceptual stage within the APQP. Through this research, it is concluded that both methodologies are synergistic and, therefore, can bring improvements for the current APQP process by leveraging the quality and assertiveness of the generation of ideas, as well as supporting to select the best concept to be taken to the next phases.

Made available in DSpace on 2016-03-15T19:36:41Z (GMT). No. of bitstreams: 1 Emerson Bertaglia de Paula.pdf: 2673349 bytes, checksum: 7ced38cf4db0e9c40ec1a57cbdf6bf07 (MD5) Previous issue date: 2014-02-13 / Universidade Presbiteriana Mackenzie / McPherson shock absorber is a metallic structure that is used to link body to wheels of vehicles, most part of shock absorbers are produced using carbon steel low alloy of medium strength, because in this way it has a lowest cost. Due to the continuous change of market requirement, it is necessary that it be created an alternative to performance improvement and reduce fuel consumption and one possibility, it is reduce the weight of shock absorbers. There are many type of materials, metallic and no metallic that can reduce the weigh, however, dual phase steel shows an interesting alternative to substitute carbon steels, because dual phase steel does not change or demand new investments to current production process. Dual-phase steel has high mechanical properties that allow significant weight reductions. In this study there is a comparison between carbon steel and dual-phase steels, performed with current loads case used for approve McPherson shock absorbers and components. Components of shock absorber was analyzed by analytical and finite element methods. Result of this study showed that it is possible use dual-phase steel with a weight reduction of 10% to 24% for each component studied and a reduction of 7,23% for strut shock absorber. / Amortecedores McPherson são estruturas metálicas que servem de ligação entre a carroceria e as rodas do veículo e a grande maioria dos amortecedores produzidos mundialmente utilizam aço carbono de baixa liga e média resistência, pois desta forma apresentam um menor custo. Com as contínuas mudanças das exigências do mercado consumidor, é necessário que seja apresentado uma alternativa para a redução de massa dos amortecedores, pois somente desta forma tem-se um melhor desempenho com uma redução no consumo de combustíveis. Há diversos tipos de materiais metálicos e não metálicos que podem proporcionar esta redução de massa, porém o aço dual-phase apresenta uma interessante alternativa para substituição dos aços carbono, pois não gera modificações e investimentos significativos no atual processo produtivo. O aço dual-phase possui elevadas propriedades mecânicas possibilitando reduções significativas de massa. Neste estudo foi realizado um comparativo entre os aços carbono e o aço dual-phase em condições de carregamento normalmente utilizada para aprovação dos amortecedores McPherson. Os componentes estudados, foram analisados pelos métodos analítico e de elementos finitos, o resultado deste estudo mostra que é possível utilizar o aço dual-phase com uma redução de massa de 10% a 24% para cada componente estudado e uma redução no amortecedor estrutural de 7,23%.

O que se desejou investigar é se a metodologia do Design Thinking (DT) e da Teoria de Resolução de Problemas Inventivos (TRIZ) podem ser utilizadas em conjunto de maneira sinérgica na fase conceitual de um processo de desenvolvimento de produto (PDP) automotivo do tipo APQP (Advanced Product Quality Planning) com a finalidade de alavancar a criatividade na geração de ideias e, ao mesmo tempo, selecionar o melhor conceito para levar às demais fases do PDP. A presente pesquisa busca entender dentro da literatura os pontos fortes e limitações de cada uma das metodologias e, ao mesmo tempo, propõe uma forma de combiná-las à metodologia APQP. O processo proposto é então testado dentro de um projeto de redução de massa de guarnição de carroceria na região da porta de um veículo automotivo de passeio. Como ficará demonstrado, o PDP automotivo do tipo APQP, utilizando a melhoria proposta, se mostra mais eficaz ao alavancar a criatividade ao mesmo tempo que consolida uma fase de conceito dentro do APQP automotivo tradicional. Através desta pesquisa, concluiu-se que ambas as metodologias são sinérgicas e que, portanto, podem trazer melhorias para o atual processo APQP, alavancando a qualidade e assertividade da geração de ideias, bem como apoiando a seleção do melhor conceito a ser levado para as próximas fases. / This research aimed to verify whether the methodology of Design Thinking (DT) and the Theory of Inventive Problem Solving (TRIZ) could be used together synergistically in the conceptual phase of a new product development project (NPD) in the automotive industry through the also know APQP (Advanced Product Quality Planning) process. The main purpose was to leverage the creativity by generating ideas that are more qualified and, at the same time, select the best product concepts to be taken to the next phases of the NPD. This research seeks to understand within the literature the strengths and limitations of each of the methodologies and, at the same time, a proposal is made on how to integrate them into the APQP methodology. The proposed process is then tested in a project of mass reduction of the door body seal of an automotive vehicle. As shall be demonstrated, the automotive NPD, by using the improvement proposal, will become more effective by leveraging the creativity while consolidates a conceptual stage within the APQP. Through this research, it is concluded that both methodologies are synergistic and, therefore, can bring improvements for the current APQP process by leveraging the quality and assertiveness of the generation of ideas, as well as supporting to select the best concept to be taken to the next phases.

This diploma thesis describes the problems of the engine block and crankcase. As a one of the most imprortant and first part of this task is creating a 3D simulation model of a engine block and calculating load forces of engine block. The simulation and evaluation of the solution are calculated by using method finite element, software Ansys. The conclusion and ending point of the od the diploma thesis construction desing of stiffness increase.

Made available in DSpace on 2016-03-15T19:36:37Z (GMT). No. of bitstreams: 1 Kyosuke Siqueira Saito.pdf: 4273063 bytes, checksum: 72ef7d0c147daede5763573276e7efda (MD5) Previous issue date: 2013-02-15 / Universidade Presbiteriana Mackenzie / The development of new commercial vehicles have as one of its major goals increase the operational energetic efficiency or fuel consumption decrease. The vehicle´s mass reduction is one of the most direct ways to achieve this goal. The vehicle´s axles usually have its structure made of ferrous materials due to its high strength and low cost. Alternative materials with lower density and higher strength are continuosly researched and developed. Among these materials the aluminum compared with ferrous materials appears as an interesting alternative to replace ferrous alloys in some applications. The aluminum have its density significantly smaller than ferrous materials opening possibilities to significant mass reductions. In this study were performed an evaluation through the comparison of aluminum alloys and ferrous materials on different load conditions and were presented the replacement gains for each load situation. It was evaluated possibility to replace ferrous materials with aluminum alloys on commercial vehicles rear axle structures through finite element analysis as a step on a new product validation. The study results show that is possible to use the aluminum in commercial vehicle axles with mass reduction ranging from 1,1% to 61,0% without loss of structural properties. / O desenvolvimento de novos veículos comerciais tem como um de seus objetivos principais o aumento da eficiência energética operacional ou redução do consumo de combustível. A redução da massa dos veículos é uma das estratégias mais diretas para o alcance deste objetivo. Os eixos de veículos tradicionalmente têm sua estrutura feita de materiais ferrosos devido à sua alta resistência e baixo custo. Materiais alternativos de mais baixa densidade e alta resistência são pesquisados e desenvolvidos continuamente. Dentre esses materiais, o alumínio, comparado com materiais ferrosos tem-se mostrado uma alternativa interessante para a substituição de ligas ferrosas para algumas aplicações. O alumínio possui uma densidade muito inferior a dos ferrosos abrindo a possibilidade de ganhos significativos de massa. Neste estudo foi feito uma avaliação através da comparação entre ligas de alumínio e materiais ferrosos em diferentes condições de carregamento e apresentado os ganhos da substituição em cada condição de carregamento. Foi avaliada a possibilidade de substituir materiais ferrosos por ligas de alumínio na estrutura de eixos traseiros de veículos comerciais através de uma análise por elementos finitos como uma etapa da validação de um novo produto. Os resultados do estudo mostram que é possível usar o alumínio na estrutura de eixos de veículos comerciais com redução de massa variando de 1,1% a 61,0% sem perda de características estruturais.

This diploma thesis applies to the light-weight itself of a connecting rod of a mass-produced tractor-engine. As a one of the most important and first part of this task is creating a 3D simulation model of a connecting rod. The strenght calculation is following skip factor of the light-weight, the exact calculated dimension of relieve is providing by means of an engine imbalance including the connecting rod. The outcome data of research are instrumental to the new relieve and strengthen 3D design. The conclusion and ending point of the diploma thesis evaluate results.

The presentation describes the development of a new mountain bicycle pedal with a special magnetic safety locking mechanism by means of the finite element method (FEM). It starts with a description of the predecessor mountain bike pedal “Enduro” from magped GmbH and sets out the development objectives for the new pedal named “Enduro2”. The complete development activities like load determination and load assumptions, FEM analysis of the initial draft, subsequent optimization steps for strength improvement and mass reduction, bearing design and analysis, and prototype testing are described. The presentation ends with a chapter about creating computer generated images for marketing material of the pedal. The presentation is structured as follows: 1. Introduction: -Description of the predecessor mountain bike pedal “Enduro1” by magped GmbH -The magnetic safety locking mechanism -Overview of the magped GmbH product portfolio -Short magped GmbH company presentation -Development objectives and initial design draft of the successor pedal model “Enduro2” 2. Determination of the load cases for design & optimization: -Loads for bicycle pedals acc. to DIN ISO 4210 -Chosen load cases and qualification test program 3. Strength analysis and weight optimization of the pedal axis: -Pre-optimization steps -Optimized shape: Theoretical consideration of the pedal axis -Optimized design description -Obtained mass reduction -User tips for shape / notch stress optimization -Comparison with the axis of a competitor 4. Strength analysis and weight optimization of the pedal body: -Challenges in pedal body design -Computed load cases -Design result and mass savings 5. Bearing design and analysis: -Sliding bearing layout -Ball bearing layout: Bearing forces computation by FEM due to over-determined system -Description of the Creo Simulate FEM model -Bal bearing life span 6. Product testing: -Test program performed by the zedler-institute -Testing of the first test batch of pedals with hollow bored axis -Testing of the first test batch of pedals without hollow bored axis 7. Realized mass savings: -Magped Enduro1 and Enduro2 on the balance and comparison with the magped Gravel pedal 8. Creation of marketing material for the final product: -Still image creation -Photorealistic rendering containing FEM loading sequences / Der Vortrag beschreibt die Entwicklung eines neuen Mountainbike-Pedals mit einer speziellen magnetischen Sicherheitsverriegelung mittels der Finite-Elemente-Methode (FEM). Er beginnt mit einer Beschreibung des Vorgänger-Mountainbike-Pedals 'Enduro' der magped GmbH und legt die Entwicklungsziele für das neue Pedal mit dem Namen 'Enduro2' dar. Die gesamten Entwicklungsaktivitäten wie Lastermittlung und Lastannahmen, FEM-Analyse des ersten Entwurfs, nachfolgende Optimierungsschritte zur Festigkeitsverbesserung und Massenreduzierung, Lagerauslegung und -analyse sowie Prototypentests werden beschrieben. Die Präsentation endet mit einem Kapitel über die Erstellung computergenerierter Bilder für die Verwendung in Marketingmaterial des Pedals. Gliederung des Vortrages: 1. Einleitung: -Beschreibung des Vorgänger-Mountainbike-Pedals 'Enduro1' der magped GmbH -Die magnetische Sicherheitsverriegelung des Pedals -Überblick über das Produktportfolio der magped GmbH -Kurze Firmenpräsentation der magped GmbH -Entwicklungsziele und erster Designentwurf des Nachfolgemodells 'Enduro2' 2. Ermittlung der Lastfälle für Design & Optimierung: -Belastungsfälle für Fahrradpedale nach DIN ISO 4210 -Ausgewählte Lastfälle und Qualifikations-Testprogramm 3. Festigkeitsanalyse und Gewichtsoptimierung der Pedalachse: -Vor-Optimierungsschritte -Optimierte Form: Theoretische Betrachtung der Pedalachse -Beschreibung der optimierten Form -Erzielte Massenreduzierung -Anwendertipps zur Form- / Kerbspannungsoptimierung -Vergleich mit der Achse eines Wettbewerbers 4. Festigkeitsanalyse und Gewichtsoptimierung des Pedalkörpers: -Herausforderungen bei der Konstruktion von Pedalkörpern -Berechnete Lastfälle -Konstruktionsergebnis und Gewichtseinsparung 5. Lagerkonstruktion und -analyse: -Auslegung der Gleitlager -Auslegung der Kugellager: Berechnung der Lagerkräfte durch die FEM aufgrund des statisch überbestimmten Systems -Beschreibung des Creo Simulate FEM-Modells -Lebensdauer der Kugellager 6. Produktprüfung: -Testprogramm, durchgeführt durch das zedler-Institut -Erprobung der ersten Versuchscharge von Pedalen mit hohlgebohrter Achse -Prüfung der ersten Versuchscharge von Pedalen ohne hohlgebohrte Achse 7. Realisierte Masseneinsparung: -Magped Enduro1 und Enduro2 auf der Waage und Vergleich mit dem magped Gravel-Pedal 8. Erstellung von Marketingmaterial für das Endprodukt: -Erstellung von computergenerierten Fotos -Fotorealistisches Rendering mit FEM-Belastungssequenzen