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Building a standard operating procedure for the analysis of mass spectrometry dataMalmqvist, Niklas January 2012 (has links)
Mass spectrometry (MS) is used in peptidomics to find novel endogenous peptides that may lead to the discovery of new biomarkers. Identifying endogenous peptides from MS is a time-consuming and challenging task; storing identified peptides in a database and comparing them against unknown peptides from other MS runs avoids re-doing identification. MS produce large amounts of data, making interpretation difficult. A platform for helping the identification of endogenous peptides was developed in this project, including a library application for storing peptide data. Machine learning methods were also used to try to find patterns in peptide abundance that could be correlated to a specific sample or treatment type, which can help focus the identification work on peptides of high interest.
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