Spear phishing attacks pose an ongoing threat to organizational cybersecurity, requiring effective response measures. This study examines measures that can be implemented by Swedish organizations to respond to successful spear phishing attacks, focusing on technical solutions and cybersecurity frameworks. Through 14 semi-structured interviews with incident response teams and cybersecurity professionals, insights were gathered on the effectiveness of these measures as well as the challenges that may be faced in complying with them. The results indicate the presence of two primary response measures: technical solutions used during and after the successful attack. In addition, cybersecurity frameworks play a critical role in guiding organizations in countering successful spear phishing attacks. While the results provide valuable insight, their effectiveness varies depending on the challenges the organization may face in complying with measures. This study underscores the importance of comprehensive and effective measures to respond to successful spear phishing attacks and improve organizational resilience to evolving cyber threats.