Thesis (Ph.D)--University of Wollongong, 2003. / Typescript. Includes bibliographical references: leaf 366-409.

Thesis (Ph.D.)--Aberdeen University, 2008. / Title from web page (viewed on Apr. 14, 2009). Includes bibliographical references.

Made available in DSpace on 2014-06-11T19:27:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-12-05Bitstream added on 2014-06-13T20:47:52Z : No. of bitstreams: 1 stephan_c_me_botfm.pdf: 793749 bytes, checksum: d0bc073c8486e1bcad6fa681e03ab1c8 (MD5) / Fundação para o Desenvolvimento Médico e Hospitalar (Famesp) / O objetivo deste estudo foi avaliar a associação entre a densidade mineral óssea da coluna lombar e do fêmur e o perfil lipídico e lipoprotéico em pacientes pósmenopáusicas com osteoporose. Foram avaliadas 351 pacientes com média etária de 64,4 anos, em estudo de corte transversal. Foram analisadas as correlações entre a densidade mineral óssea da coluna lombar e as distintas variáveis do perfil lipídico e lipoprotéico. Iguais correlações também foram estudadas em relação à densidade mineral óssea do colo do fêmur. Levou-se em conta para as referidas análises o tempo de pós-menopausa e o índice de massa corporal das pacientes. Ao final, pode-se concluir pela existência de associação significativa entre os níveis plasmáticos de HDLC e a presença de osteoporose do colo do fêmur somente nas pacientes com mais de 10 anos de pós-menopausa. Estas apresentaram níveis plasmáticos de HDL-C significativamente mais elevados. Não houve associação entre a densidade mineral óssea do colo do fêmur e as demais variáveis do perfil lipídico e lipoprotéico (CT, LDL-C e TG). Também não houve associação entre a densidade mineral óssea da coluna vertebral e as variáveis analisadas do perfil lipídico e lipoprotéico (CT, LDL-C, HDL-C e TG) / The aim of this study was to analyze the association between the bone mineral density (BMD) in the lumbar spine and hip and the lipid and lipoprotein profile in post-menopause women with osteoporosis. A sectional study was performed with 351 women. Their mean age was 64,4 years. We performed a linear correlation between the lumbar spine BMD and the variables of the lipid and lipoprotein profile (CT: total cholesterol; HDL-C: high lipoprotein density; LDL-C: low lipoprotein density; TG: tryglicerides). The same procedure was done with the hip BMD. We also analized the time since menopause and bone mass index. In the end of the study we concludes that there was a significant association between HDL-C plasmatic levels in the hip only in women with more than 10 years since menopause. They had HDL-C plasmatic levels signifcantly higher. There wasnþt an association between the hip BMD and the other lipid and lipoprotein variables (CT, LDL-C,TG). Also, there wasnþt an association between the lumbar spine BMD and the lipid and lipoprotein variables (CT, HDL-C, LDl-C, TG)

Orientador: Aarão Mendes Pinto-Neto, Delio Marques Conde / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-10T01:32:05Z (GMT). No. of bitstreams: 1 Fernandes_AnaLuciaRibeiroValadares_D.pdf: 906029 bytes, checksum: 11e5aaa84cce63b6482eb194df48b4a1 (MD5) Previous issue date: 2007 / Resumo: Objetivos: Avaliar aspectos da sexualidade e seus fatores associados em mulheres de meia-idade, com 11 anos ou mais de escolaridade. Métodos: Estudo populacional de corte transversal, com questionário anônimo auto-respondido por 378 mulheres brasileiras residentes em Belo Horizonte, Minas Gerais, entre 40 e 65 anos, com 11 anos ou mais de escolaridade, no período de maio a setembro de 2005. o instrumento de avaliação baseou-se no Short Personal Experiences Questionnaire (SPEQ). O escore de sexualidade foi calculado através da análise multivariada de sete componentes: presença de fantasias sexuais, grau de desejo, freqüência de atividade sexual, satisfação nas atividades sexuais, freqüência de excitação, orgasmo e a autoclassificação da vida sexual. Considerou-se escore de sexualidade abaixo da mediana como sexualidade ruim e maior ou igual à mediana como sexualidade boa. Para se investigar os fatores associados, os dados foram analisados usando-se a análise bivariada, com aplicação dos testes qui-quadrado e exato de Fisher. Por último, a análise por regressão múltipla de Poisson foi realizada. A razão de prevalência (RP) e o respectivo intervalo de confiança de 95% (IC 95%) foram calculados. Resultados: 276 questionários foram avaliados e, destes, 219 mulheres relataram ter parceiro sexual. A mediana do escore de sexualidade foi 9,0 (variação: 2,45-13,77). A análise de regressão múltipla mostrou que a prevalência de escore de sexualidade abaixo da mediana foi maior nas mulheres com mais idade e naquelas com insônia. Ter parceiro sexual e sentir-se bem indicaram efeito protetor contra baixo escore de sexualidade. Em mulheres com parceiro sexual, a prevalência de escore abaixo da mediana foi maior nas que moravam com o parceiro, que estavam na transição menopausal ou na pós menopausa e nas hipertensas. Ter relações sexuais com penetração e satisfação com o parceiro como amante indicaram efeito protetor contra escore de sexualidade abaixo da mediana. Conclusões: Mulheres com mais idade e que relataram insônia tiveram maior chance de ter sexualidade ruim, enquanto as com parceiro sexual e que se sentiram bem tiveram maior probabilidade de apresentar sexualidade boa. No grupo de mulheres que tinham parceiro sexual, a sexualidade foi negativamente associada ao fato de residir com o parceiro, estar na transição menopausal ou pós-menopausa e ser hipertensa. A satisfação com o parceiro como amante e ter relações sexuais com penetração diminuíram a probabilidade de apresentar sexualidade baixa / Abstract: Objectives: To evaluate aspects of sexuality and associated factors in middle aged women with 11 or more years of formal education. Methods: with living in Belo Horizonte (Minas Gerais), between 4, in the period between May and September 2005. The evaluation instrument was based on the Short Personal Experíences Questíonnaíre (SPEQ). Sexuality score was calculated from the multivariate analysis of the seven components: presence of sexual fantasies, intensity of desire, frequency of sexual activities, satisfaction in sexual activities, frequency of arousal, orgasm and self-classification of sexual life. The sexuality score below the median was considered bad sexuality and equal or higher than median as good sexuality. To investigate associated factors, data were analyzed using bivariate analysis and chi-squared and Fisher's exact tests were applied. Finally, Poisson multiple regression analysis was performed. The software used was Stata 7.0. Prevalence ratios (PR) and their 95% confidence intervals (95% CI) were calculated. Results: 276 questionnaires were evaluated and from these 219 women reported having sexual partners. The median sexuality score was 9.0 (range: 2.45-13.77). Multiple regression analysis showed that the prevalence of below median scores was higher in older women and in those with insomnia. Having a sexual partner and feeling well was associated with a protective effect against a below median sexuality score. In women with sexual partner, the prevalence of below median scores was higher in women who lived with their sexual partner, were in the menopausal transition or postmenopausal and in hypertensive women. Sexual activities involving penetration and a score of 6 for satisfaction with partner as a lover were indicative of a protective effect against below median sexuality score. Conclusions: Older women and those with insomnia were more likely to have a bad sexuality, whereas the ones with a sexual partner and who felt well were more likely to have a good sexuality. In the group which had sexual partner, the sexuality of women in midlife was negatively associated with the fact of living with a sexual partner, being in the menopausal transition or postmenopausal and being hypertensive. Satisfaction with the sexual partner as a lover and having sexual activities with penetration decreased the chance of poor sexuality / Doutorado / Tocoginecologia / Mestre em Tocoginecologia

M.Tech. (Homoeopathy) / The climacteric describes the ongoing changes and symptoms, of the phase or transition period that may last 15-20 years in a woman's lifecycle, when ovarian function and hormonal production declines. Menopause is the permanent cessation of the menses, identified retrospectively after one year without menses and occurs within this period of climacteric (Bernstein et al. 1996). The most common symptoms of climacteric include hot flushes, night sweats, sleep disturbances, nervousness, depressive moods, feelings of vertigo, inability to concentration, joint pain, headache and heart palpitations. The most commonly used allopathic medication to palliate these symptoms is hormone replacement therapy (HRT). There are adverse side effects and risks associated with this treatment and not all women feel better on HR.T (Stoppard, 2001). The aim of this research study was to determine the efficacy of the Homoeopathic complexes Dr Reckeweg RI0® and R20® (Homoeopathic complexes) in relieving the symptoms of the climacteric. The methodology and Ethics were accepted by Higher Degrees Committee and Academic Ethics Committee on the 25 August 2008 (Ethical clearance no: 40/08). Participants were recruited by advertisements (Appendix A) at the University of Johannesburg, in health food shops and in pharmacies. This was a double blind, placebo controlled study involving thirty-two participants who were divided into two matched groups based on the severity of the menopausal symptoms. Volunteers were selected . using the exclusion and inclusion criteria. Volunteers meeting the inclusion criteria completed the information and consent form (Appendix B), and a patient profile and case history (Appendix C) were taken. The participants were randomly allocated to an experimental or control group, and given sets of medication (Remedy A and B, 50ml bottles) to take for a period of eight weeks (Appendix D). The participants took 10 drops of Remedy A (R10® or placebo) in the morning and Remedy B (R20® or placebo) at night. The participants were requested to complete the abbreviated Kupperman Menopause Index (KMI) weekly. The abbreviated KMI (Appendix E) scores were added...

Dissertation submitted in partial compliance with the requirements for the Master's Diploma in Technology in the Department of Homoeopathy at Technikon Natal, 1994. / The object of the present research trial was to evaluate the efficacy of a single homoeopathic medication, Cholesterinum, in the ninth atcenuation (9CH) in the treatment of hypercholesterolaemia. Special attention was paid to its effect on total choles~erol (TC) levels and the high-density lipoprotein cholesterol/ low-density lipoprotein cholesterol (HDL-C/LDL-C) ratio. / M

M.Tech. / Menopause refers to the natural cessation of the menstrual cycle at the end of the reproductive years, and is usually defined retrospectively after twelve consecutive months of amenorrhoea. Climacteric is the term used to describe the life period surrounding menopause. It begins with physiological changes that mark the transition between the reproductive and post-reproductive years (Lewis and Bernstein, 1996). The mean age of menopause is 51 years, with a normal range from 45 to 56 years (Chamberlain and Malvern, 1996). There are many symptoms associated with menopause, including hot flushes and night sweats, headaches, sleep difficulties, vaginal dryness and loss of libido, urinary problems, joint and muscle pains, depression, irritability, and poor memory and concentration. Long-term risks and effects include osteoporosis and coronary heart disease (MacGregor, 2000). The aim of this study was to determine the efficacy of the homoeopathic similimum in the treatment of climacteric symptoms. The research study was advertised in local newspapers, pharmacies, and on the Doornfontein campus of the University of Johannesburg in order to recruit volunteers for the study. All volunteers were required to complete a Suitability Criteria Questionnaire. Following this, ten participants were selected who met the inclusion criteria. The study involved four homoeopathic consultations for each participant over a period of three months. During the first consultation a consent form was completed, the procedures of the research were explained to the participant, a full case history was taken, and a physical examination was performed. According to each participant’s individualized physical, mental and emotional symptoms ascertained from the case history, the researcher determined a suitable similimum remedy. A similimum remedy can be defined as the single remedy that fits the symptom picture (Digby, 1997). The abbreviated Kupperman Menopause Index was completed by each participant at the beginning of the treatment, and then at four-weekly intervals for the duration of the twelve week trial. The results were then transferred to the participants’ main Kupperman Menopause Index and compared, thus determining the effect of the homoeopathic similimum in treating climacteric symptoms.

M.Tech. / Menopause is defined as the physiological cessation of menses due to decreased ovarian function and is established when the menses have not occurred for a year, usually occurring at a median age of 50.8 years. The period around the menopause is a time of transition that can contribute to both emotional and physical symptoms. The purpose of the study was to determine the efficacy of the homoeopathically prepared remedy Lachesis in the treatment of the symptoms of the menopause in women whose symptoms match the symptom picture of Lachesis. Thirty female volunteers between the ages of sixty and sixty years were recruited from the Johannesburg and Potchefstroom areas. This was a single-blind study and the participants did not know if they were in the control or experimental group. The participants were required to complete an Abbreviated Kupperman Index on a weekly basis throughout the four week trial period. The Experimental group experienced a 58.27% overall decrease in average Kupperman score, compared to 28.65% of the Control group. The P-value of the total response of the trial is 0.2110, therefore there is not a significant statistical difference between the two groups over the total trial period. Although there was not a statistically significant difference for the total response between the two groups there was statistically significant differences between the two groups for the following individual symptoms: profuse sweating, depressive moods and the inability to concentrate.

Approximately 1% of women will experience menopause before the age of 40, a condition known as premature ovarian failure (POF). The goal of this thesis was to identify genetic causes of POF by examining a number of candidate factors in POF patients and control women. Carriers of FMR1 premutations (55-200 CGG repeats) are known to be at increased risk of POF. A higher prevalence of alleles between 35-54 repeats was found among POF patients (p=0.01), suggesting that risk for POF may extend outside the classic premutation range. There was no evidence for any difference in FMRI promoter methylation or gene expression between cases and controls. Allele distributions of gene polymorphisms in the androgen receptor (AR), estrogen receptor (ß, sex hormone binding globulin, and FSH receptor genes did not differ between POF patients and controls. However, haplotype at the estrogen receptor a gene, ESRI, was found to be associated with POF in a simple dominant manner (RR=9.7; 95% CI=2.6-35.6). Although the functional effect of this haplotype could not be confirmed, it may confer a more active promoter that influences risk by increasing the rate of follicular atresia. X-chromosome inactivation (XCI) skewing can indicate an abnormal X chromosome and may therefore be increased in POF patients. There was no increase in skewed XCI >90% in patients with secondary amenorrhea, however, there was a significant increase in 4 POF patients with primary amenorrhea (p=0.001). No X-chromosome abnormalities were detectable by high resolution DNA microarray, and skewed XCI may be explained by a trisomic rescue event causing reduced follicular pool. Age-related chromosome factors were assessed to determine if POF patients demonstrate an increased rate of cellular aging. With age, XCI skewing and AR methylation increase and telomere length decreases. There was no difference in skewing or methylation between patients and controls. Surprisingly telomere length was increased in POF patients (p=0.04), a finding that may be explained by abnormal estrogen exposure. Genotype at the longevity-associated APOE gene was not associated with POF. In conclusion, these findings have illuminated several new areas of research in this field and provide background for future research into POF pathogenesis. / Medicine, Faculty of / Medical Genetics, Department of / Graduate

Despite the universality, inevitability and normalcy of menopause, little is known of women's experiences. In particular, little or nothing is known of the meaning women attach to menopause. Despite (or because of) this lack of information, a controversy currently exists as to how women can best negotiate menopause, and as to the risks or benefits of hormone replacement theory. Research methodology was guided by recent studies on women's unique ways of knowing, valuing and construction of meaning. Menopause was explored within the framework of a group format with five postmenopausal coresearchers over a nine-week period. The women narrated their stories, listened to the stories of the other group members, reflected on their experiences and discussed those they had in common. Individual follow-up interviews were conducted 3 months later during which the coresearchers validated the transcript and offered additional perspectives. Despite widely varying experiences of menopause, 20 common threads were located. This study details a strong developmental and transitional component to the coresearchers' menopausal experiences, as well as the impact of a menstrual taboo and negative stereotype. / Education, Faculty of / Educational and Counselling Psychology, and Special Education (ECPS), Department of / Graduate