Global ETD Search

1	Catalytic activity and maturation of the metalloprotease-disintegrin protein, MDC9 / Atherton, Ruth Elizabeth. January 1999 (has links) Thesis (Ph. D.)--Cornell University, January, 1999. / Vita. Includes bibliographical references (leaves 138-149).
2	Metalloproteinases in development and disease / Zhou, Zhongjun, January 2004 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.
3	On the contribution of MMP-2 and MMP-9 to the postnatal cerebellar corticogenesis Ayoub, Albert E., January 2003 (has links) Thesis (Ph. D.)--West Virginia University, 2003. / Title from document title page. Document formatted into pages; contains viii, 153 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 107-135).
4	Structure-function characterization of Xenopus laevis ADAMs / Smith, Katherine Marie. January 2002 (has links) Thesis (Ph. D.)--University of Virginia, 2002. / Includes bibliographical references (leaves 153-174). Also available online through Digital Dissertations.
5	The ADAMs : a novel family of cell surface proteins with adhesive and protease activity / Garton, Kyle Justin. January 2002 (has links) Thesis (Ph. D.)--University of Washington, 2002. / Vita. Includes bibliographical references (leaves 189-230).
6	Choroidal neovascularization (CNV) : clinical and experimental aspects / Berglin, Lennart, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / CD-ROM i ficka. Härtill 5 uppsatser.
7	Studies of cell migration and matrix protease production in human lung cancer cell lines / Bredin, Cecilia G., January 2004 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.
8	MMP-10 is overexpressed, proteolytically active and a potential target for therapeutic intervention in human lung carcinomas Gill, Jason H., Kirwan, Ian G., Seargent, Jill M., Martin, Sandie W., Tijani, S., Anikin, V.A., Mearns, A.J., Bibby, Michael C., Anthoney, Alan, Loadman, Paul January 2004 (has links) No / Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor development and expansion. This study analysed MMP-10 protein expression and activity in human lung tumors of various grade, stage, and type to address the relationship between MMP-10 and tumor characteristics and to evaluate MMP-10 as a therapeutic target in non small cell lung carcinoma (NSCLC). Unlike the majority of MMPs, MMP-10 was located in the tumor mass as opposed to tumor stroma. MMP-10 protein was observed at low levels in normal human lung tissues and at significantly higher levels in all types of NSCLC. No correlation was observed between MMP-10 protein expression and tumor type, stage, or lymph node invasion. To discriminate between active and inactive forms of MMP-10 in samples of human NSCLC, we have developed an ex vivo fluorescent assay. Measurable MMP-10 activity was detected in 42 of 50 specimens of lung cancer and only 2 of 10 specimens of histologically normal lung tissue. No relationship was observed between MMP-10 activity levels and clinicopathologic characteristics. Our results suggest that MMP-10 is expressed and active at high levels in human NSCLC compared to normal lung tissues, and, as such, is a potential target for the development of novel therapeutics for lung cancer treatment. Tumour Markers Heterologous Transplantation Animals Carcinoma Cell line Tumour Enzyme activation Immunohistochemistry Lung neoplasms Humans Matrix Metalloproteinase 10 Metalloendopeptidases Mice Biological analysis
9	Recombinant AAV gene therapy and delivery for Alzheimer's disease Carty, Nikisha Christine. January 2009 (has links) Dissertation (Ph.D.)--University of South Florida, 2009. / Title from PDF of title page. Document formatted into pages; contains 193 pages. Includes vita. Includes bibliographical references.

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