Thesis (M.S.)--University of Wyoming, 2008. / Title from PDF title page (viewed on June 23, 2009). Includes bibliographical references (p. 58-60).

Thesis (M.S.)--University of North Carolina at Wilmington, 2006. / Includes bibliographical references.

Thesis (M.A.)--Oregon State University, 2007. / Printout. Includes bibliographical references (leaves 127-131). Also available on the World Wide Web.

Prenatal methamphetamine exposure is associated with functional and neurostructural alterations, but neuroimaging investigations of these effects in infants are almost non-existent. Studies in neonates permit a degree of separation of drug exposure effects from potential confounders in the postnatal environment. Magnetic resonance imaging (MRI) was used to investigate the neurostructural effects of prenatal methamphetamine exposure on neonates recruited from a Cape Town community. Mothers were recruited during pregnancy and interviewed regarding methamphetamine use. Women in the exposure group used methamphetamine at least twice per month during pregnancy, while control mothers did not use methamphetamine. MRI scans were acquired within the first postnatal month. Anatomical images were processed using FreeSurfer and subcortical and cerebellar structures manually segmented with Freeview. Volumes were regressed with methamphetamine exposure (days/month of pregnancy) and related confounding variables, including total brain volume, gestational age at scan, exposure to cigarette smoking and infant sex. Diffusion data were processed with FSL, and diffusion tensors and tensor parameters determined using AFNI. Probabilistic tractography defined white matter connections between target regions. For the first analysis, five major white matter networks (commissural, and bilateral projection and association networks) were defined between spherical targets. For the second analysis, regions traced in the anatomical study were used as targets. Averaged DTI parameters were then calculated for each connection, and multiple regression analysis determined associations between DTI parameters and methamphetamine exposure at network level and in the individual connections. Methamphetamine exposure was associated with reduced caudate nucleus volume bilaterally, and in the right caudate following adjustment for confounders. Exposure was associated with reduced fractional anisotropy in all major white matter networks, and in individual connections within the limbic meso-cortico-striatal circuit. Exposure was associated with increased radial diffusivity in a subset of these. These results support findings in older children of methamphetamine-induced neurostructural damage, and demonstrate that such effects are already measurable in neonates. Corticostriatal circuit changes may underlie the impaired executive function observed in prenatally exposed children, and suggest a specific mechanism of damage in dopaminergic-related circuits that is consistent with the neurotoxic actions of methamphetamine.

These studies examined the in vivo pharmacokinetics and efficacy of five anti-methamphetamine monoclonal antibodies (mAbs, KD values from 11 to 250 nM) in rats. While no substantive differences in mAb systemic clearance (t1/2 = 6.1-6.9 days) were found, in vivo function was significantly reduced within 1-3 days for four of the five mAbs. Only mAb4G9 was capable of prolonged efficacy, as judged by prolonged high methamphetamine serum concentrations. MAb4G9 also maintained high amphetamine serum concentrations, along with reductions in methamphetamine and amphetamine brain concentrations, indicating neuroprotection. The combination of broad specificity for methamphetamine-like drugs, high affinity, and prolonged action in vivo suggests mAb4G9 is a potentially efficacious medication for treating human methamphetamine-related medical diseases.

Indiana University-Purdue University Indianapolis (IUPUI) / Methamphetamine (METH) is a psychostimulant with high abuse potential. Currently there are no pharmacological treatments specific for relapse to METH use disorder. Chronic METH abuse has been associated with changes to the dopamine and glutamate neurotransmitter systems, as well as inflammation. Phosphodiesterase-4 inhibitors are known to affect cAMP involved in dopaminergic and glutamatergic neurotransmission, as well as having anti-inflammatory action. In pre-clinical models, phosphodiesterase inhibitors can reduce behaviors associated with the self-administration of drugs of abuse if given directly before tests of relapse-like behavior. However, they have not been examined in the more clinically relevant context as a treatment for use during abstinence from drugs of abuse. To address this gap, a METH self-administration model in the rat was used in which roflumilast, a phosphodiesterase 4 inhibitor, was administered during the abstinence period before a relapse test. The overarching hypothesis was that roflumilast inhibited inflammation associated with METH self-administration abstinence to reduce subsequent relapse-like behaviors. A detailed behavioral analysis showed that the chronic treatment with roflumilast during 7 days of forced abstinence reduced relapse-like behavior to METH seeking and METH taking. Roflumilast treatment during 7 days of forced abstinence did not affect subsequent sucrose seeking and sucrose taking behaviors. Biochemical analyses of proteins related to dopamine and glutamate neurotransmission did not reveal changes in these neurotransmitter systems, nor was there evidence of overt inflammation. These data suggest that roflumilast may be a treatment for METH use disorder that is effective when taken during abstinence, but further studies related to the mechanism of action of roflumilast are needed.

No description available.

Thesis (Ph. D.)--West Virginia University, 2004. / Title from document title page. Document formatted into pages; contains xiii, 133 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 110-125).

Magister Psychologiae - MPsych / Substance abuse is a global epidemic which is internationally recognised as an illness, characterised as being primary, chronic, progressive and terminal. Methamphetamine in South Africa is now drawing the interest of younger first time drug users from as young as thirteen years old, who are presenting at various rehabilitation centres in Cape Town. Many of the low socio-economic status areas are afflicted communities in Cape Town, which has been recognised by the Provincial government as an area troubled with societal concerns such as poverty, risky behaviour while using drugs or alcohol, violence and social disintegration. This qualitative study has its focus on the community leaders‟ perceptions of risk factors contributing to the spread of methamphetamine addiction in Manenberg and Lamberts Bay. The stigma attached to this area is often one that paints the portrait of a crime-ridden, desolate and poor community. The aim is to identify which risk factors community leaders believe are contributing to the increase of methamphetamine addiction in the area. Bronfenbrenner's social-ecological systems approach will act as a framework for this research study as well as utilising thematic analysis. It provides an understanding by which various systems within a community function and mutually co-operate. This allows one to expand on connotations ingrained in data collected from study participants.

Doctor of Philosophy / Department of Sociology, Anthropology, and Social Work / L. Susan Williams / Since the early 1970s, the United States has grown increasingly reliant on the criminal justice system to manage a wide array of social problems. Aggressive drug control policies and an over-reliance on imprisonment helped produce the world’s largest prison and correctional population, often described as mass imprisonment. Within this context, the study provides an explanatory account of the political, cultural, and social conditions that encourage states like Kansas to pursue methamphetamine as a major public concern, and to a greater degree than other states with relatively higher meth problems. Ultimately, and most important, the study makes a theoretical contribution by demonstrating how meth control efforts, analogous to previous drug control campaigns, extends punitive drug control rationalities to new cultural contexts and social terrains beyond the so-called ghetto of the inner city, thereby reinforcing and extending the logics of mass imprisonment.