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MicroRNA regulation of prostate cancer desensitization to androgen receptor antagonist drugs during androgen deprivation therapyLorch, Robert A. 01 May 2011 (has links)
The current standard treatment of prostate cancer by androgen deprivation therapy involves using drugs such as bicalutamide (Casodex) to antagonistically block androgen receptors that are normally present within prostate cells. Usually, the therapy is successful in the short run at limiting the growth of prostate cancer. However, in virtually all cases tumors begin to grow aggressively again after several months of treatment and new therapies must be started. The mechanism by which these prostate cells transform from androgen sensitive to androgen independent and anti-androgen resistant is unclear. In this study, we investigated the role of microRNAs, small 15 to 18 nucleotide regulatory RNAs, in regulating the desensitization of prostate cancer cells to the androgen receptor antagonist drug bicalutamide. In order to identify significant microRNAs, quantitative PCR was used to obtain genome-wide microRNA expression levels of 885 human microRNAs at different timepoints for androgen sensitive LNCaP cancer cells treated with bicalutamide and for untreated control cells in tissue culture. Analysis of microRNA expression by clustering analysis and by statistical comparisons of treatment groups resulted in identification of 28 microRNAs that have altered expression in the progression process. In silico target prediction analysis was performed with the microRNAs shown to have altered expression, and a group of genes predicted to be under microRNA regulatory control during cancer progression to resistance was identified. A microRNA expression profile can be useful in developing more effective prognostic and therapeutic tools for prostate cancer.
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Mechanistic Insights into Glucocorticoid-induced Apoptosis and Autophagy in Lymphoid MalignanciesMolitoris, Jason K. January 2011 (has links)
No description available.
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Cell and developmental stage specific role of Dicer1 in the lung epitheliumGardner, Margaret A., B.S. 16 June 2015 (has links)
No description available.
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MiR-34a Regulates the Invasive Capacity of Canine Osteosarcoma Cell LinesLopez, Cecilia Montes 24 May 2017 (has links)
No description available.
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Roles of microRNAs in TRAIL resistance and tumorigenesis in Non-Small Cell Lung CancerJoshi, Pooja 11 October 2017 (has links)
No description available.
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MiR-Drug Relationships: Mining and discovering bi-domain dense subclusters using greedy randomized algorithmShahdeo, Sandhya 20 April 2011 (has links)
No description available.
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Characterization of miR-21 and miR-196b in Myeloid Signaling PathwaysStoffers, Sara L. 26 September 2011 (has links)
No description available.
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MicroRNA in the Pathogenesis of Allergic InflammationLu, Thomas X. 19 April 2012 (has links)
No description available.
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MICRORNA REGULATION OF VENTILATOR INDUCED LUNG INJURY AND PRESSURE-INDUCED LUNG INFLAMMATIONNelson, Kevin Joseph 29 September 2016 (has links)
No description available.
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Role of microRNA-29 in the Pathogenesis of B-Cell Chronic Lymphocytic LeukemiaSantanam, Urmila 07 October 2010 (has links)
No description available.
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