Thesis (Th. M.)--Covenant Theological Seminary, 2007. / Abstract. Includes bibliographical references (leaves 125-128).

Bibliography: leaves 180-181.

The Clarno Formation is a series of volcanic, volcaniclastic, and related intrusive rocks located in central Oregon. It is the westernmost extent of a broader Eocene magmatic belt that covers much the western United States. The magmatic belt stretches eastward from Oregon to western South Dakota, and from the Canadian Yukon to northern Nevada. While once attributed to subduction of the Farallon Plate under North America, more recent work suggests that a more complex tectonic regime involving extension was in place during the early Cenozoic. In the vicinity of Mitchell, Oregon, the Clarno Formation is well represented along with Mesozoic metamorphic and sedimentary units, and younger Tertiary volcanic and volcaniclastic units. In this area, Clarno volcanic activity occurred from ~52-42 Ma, producing mostly andesites and related volcaniclastic rocks. The Mitchell area is also underlain by related intrusive bodies ranging from basalt to rhyolite in composition. The Clarno was most active at ~49 Ma, and is dominantly calcalkaline. In addition, there are several coeval alkaline and peraluminous intrusives also scattered throughout the Clamo Formation. While these suites are less voluminous than the calc-alkaline magmatism, they offer insight into the tectonic and magmatic processes at work in this area during the Eocene. Whereas silicic intrusions are common in the Clarno, the high-silica rhyolite dike on the south face of Scott Butte is unusual due to its large garnet phenocrysts. The existence of primary garnet in rhyolitic magmas precludes middle to upper crustal genesis, a common source for silicic magmas. ⁴⁰Ar/³⁹Ar age determinations of the biotite indicate an age of ~51 Ma. This is after andesitic volcanism had commenced, but prior to the most active period of extrusion. The presence of the almandine garnet indicates that the dike represents partial melting of lower crustal (18-25 km) material. The presence of a high field strength element (HFSE) depletion commonly associated with subduction are magmatism indicates that either the source material had previously been metasomatised, or that some subduction melts/fluids (heat source) mixed with the crustal melt. Two alkaline suites, a high-K calc-alkaline basanite (Marshall and Corporate Buttes) and alkaline minette/kersantite lamprophyres (near Black Butte and Mud Creek), were emplaced ~49 Ma, during the height of calc-alkaline activity. The basanite lacks the HFSE depletion common in the other Clarno rocks. Instead it has a HIMU-type (eg. St Helena) ocean island basalt affinity, resulting from partial melting of enriched asthenospheric mantle. In contrast, the lamprophyres represent hydrous partial melts of metasomatized litho spheric mantle veins and bodies. Alkaline magmatism was not limited to the most active periods of calc-alkaline activity. The emplacement of an alkali basalt (Hudspeth Mill intrusion) at ~45 Ma occurred four million years after the largest pulse of volcanism, but still during calcalkaline activity. This alkali basalt represents partial melting of metasomatized lithospheric mantle. The occurrence of these alkaline suites coeval with the calc-alkaline activity is significant in that it disputes prior subduction theories for the broader Eocene magmatism that are based on spatial and temporal variations from calc-alkaline to alkaline magmatism. These suites also give further insight into the complex tectonic regime that existed in Oregon during the Eocene. The occurrence of asthenospheric melts not caused by fluid fluxing, along with lower lithospheric alkaline melts, are normally associated with extension. Extension provides these magmas with both the mechanism for melting, and the ability to reach shallow crust with little or no contamination. Extension is in agreement with both White and Robinson's (1992) interpretation that most Clarno Formation deposition occurred in extensional basins, and with other provinces in the broader Eocene magmatic belt. / Graduation date: 2002

Thesis (M.S.)--Florida State University, 2004. / Advisor: Dr. Cheryl Ward, Florida State University, College of Arts and Sciences, Department of Anthropology. Title and description from dissertation home page (viewed June 16, 2004). Includes bibliographical references.

Thesis (Th. M.)--Covenant Theological Seminary, 2007. / Abstract. Includes bibliographical references (leaves 125-128).

Thesis (M.A.)--Villanova University, 2008. / English Dept. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1974. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Washington, 2007. / Includes bibliographical references (leaves 377-391).

No description available.

La fonction endocrine du pancréas est essentielle pour l'homéostasie du glucose parce que les îlots pancréatiques contiennent le seul type des cellules endocrines, nommées cellules bêta, qui sont capable de produire et sécréter de l’insuline. Le facteur de transcription RFX6, maintenu dans toutes les cellules endocrines matures, est essentiel pour le développement, l'identité et la fonction des cellules bêta. Chez l'homme, des mutations de RFX6 causent le syndrome de Mitchell-Riley, un trouble du développement caractérisé par un diabète néonatal et des malformations du système gastro-intestinal. La recherche des cibles de RFX6 dans les îlots murins a révélé que le facteur de transcription Mlxipl est directement régulé par RFX6. Dans cette thèse, nous avons étudié le mécanisme de la régulation transcriptionnelle de Mlxipl par RFX6 ainsi que les rôles de RFX6 et MLXIPL dans les cellules bêta adultes. Nous avons démontré que RFX6 se lie au premier intron de Mlxipl qui contient un motif de liaison (xbox) critique, et nous avons identifié les cofacteurs de ce processus. En comparant l’effet de la répression de Rfx6 et Mlxipl dans des milieux riches ou faibles en glucose dans la lignée cellulaire bêta Ins-1 832/13 sur le transcriptome, nous avons déterminé les programmes génétiques contrôlés par RFX6 et MLXIPL. / Pancreatic endocrine function is critical for glucose homeostasis because pancreatic islets contain the only cells of the body, the beta cells, capable of producing and secreting insulin. The transcription factor RFX6 is maintained in all mature islet cells and is as an essential regulator of beta cell development, identity and function. In humans, RFX6 mutations cause Mitchell-Riley syndrome, a developmental disorder characterized by neonatal diabetes and malformations of the digestive tract. The search for RFX6 targets in murine islets revealed that the transcription factor Mlxipl is directly regulated by RFX6. In this thesis, we investigated the mechanism of Mlxipl transcriptional regulation by RFX6, and the respective roles of RFX6 and its downstream target MLXIPL in adult beta cells. We demonstrated that RFX6 binds to the first intron of Mlxipl that contains a critical RFX binding motif (xbox), and we identified cofactors of this process. By comparing the changes in the transcriptomes linked to the loss of RFX6 or MLXIPL in the pancreatic beta cell line Ins-1 832/13 and the glucose level, we determined the genetic programs controlled by RFX6 and MLXIPL.