Global ETD Search

821	Characterization of the roles of mitochondria in the toxicity of α-synuclein in a respiratory cell model Gillespie, Breonna Elizabeth 01 June 2023 (has links) No description available. Biology α-synuclein α-syn α-syn toxicity cellular respiration respiratory cell model mitochondrial damage mitochondria
822	VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation Kayvanpour, Elham, Wisdom, Michael, Lackner, Maximilian K., Sedaghat-Hamedani, Farbod, Boeckel, Jes-Niels, Müller, Marion, Eghbalian, Rose, Dudek, Jan, Doroudgar, Shirin, Maack, Christoph, Frey, Norbert, Meder, Benjamin 09 February 2024 (has links) Mutations in mitochondrial aminoacyl-tRNA synthetases (mtARSs) have been reported in patients with mitochondriopathies: most commonly encephalopathy, but also cardiomyopathy. Through a GWAS, we showed possible associations between mitochondrial valyl-tRNA synthetase (VARS2) dysregulations and non-ischemic cardiomyopathy. We aimed to investigate the possible consequences of VARS2 depletion in zebrafish and cultured HEK293A cells. Transient VARS2 loss-offunction was induced in zebrafish embryos using Morpholinos. The enzymatic activity of VARS2 was measured in VARS2-depleted cells via northern blot. Heterozygous VARS2 knockout was established in HEK293A cells using CRISPR/Cas9 technology. BN-PAGE and SDS-PAGE were used to investigate electron transport chain (ETC) complexes, and the oxygen consumption rate and extracellular acidification rate were measured using a Seahorse XFe96 Analyzer. The activation of the integrated stress response (ISR) and possible disruptions in mitochondrial fatty acid oxidation (FAO) were explored using RT-qPCR and western blot. Zebrafish embryos with transient VARS2 loss-of-function showed features of heart failure as well as indications of CNS and skeletal muscle involvements. The enzymatic activity of VARS2 was significantly reduced in VARS2-depleted cells. Heterozygous VARS2-knockout cells showed a rearrangement of ETC complexes in favor of complexes III2, III2 + IV, and supercomplexes without significant respiratory chain deficiencies. These cells also showed the enhanced activation of the ISR, as indicated by increased eIF-2 phosphorylation and a significant increase in the transcript levels of ATF4, ATF5, and DDIT3 (CHOP), as well as disruptions in FAO. The activation of the ISR and disruptions in mitochondrial FAO may underlie the adaptive changes in VARS2-depleted cells. info:eu-repo/classification/ddc/610 ddc:610
823	The Role of Mitochondrial Thioesterase-I, Uncoupling Protein-3, and CD36 in Cardiac Mitochondria King, Kristen L. January 2008 (has links) No description available. Biology, Animal Physiology Mitochondrial Thioesterase-I Uncoupling Protein-3 CD36 Cardiac Mitochondria
824	The functional significance of mitochondrial supercomplexes in C. elegans Suthammarak, Wichit January 2011 (has links) No description available. Biochemistry Biomedical Research Genetics mitochondrial supercomplexes combined complex deficiency supercomplexes in C. elegans
825	Genes Encoding Succinate Dehydrogenase as Susceptibility Factors in Cowden and Cowden-Like Syndrome Ni, Ying 27 August 2012 (has links) No description available. Biomedical Research Genetics Molecular Biology SDH Cowden syndrome PTEN ROS vitamin E p53 mitochondrial metabolism
826	Human Mitochondrial DNA and Endogenous Bacterial Surrogates for Risk Assessment of Graywater Reuse Zimmerman, Brian D. 17 October 2014 (has links) No description available. Environmental Engineering Human mitochondrial DNA graywater risk assessment metagenomics bacterial pyrosequencing qPCR
827	The spectral phasor approach as a tool for monitoring the autofluorescence of mitochondrial metabolism and its application to high pressure studies Maltas, Jeffrey A. 18 August 2014 (has links) No description available. Physics Biology Biochemistry Biophysics NADH spectrum-shape high-pressure spectral-phasor autofluorescence mitochondrial metabolism metabolism
828	Effects of Pramlintide on Mitochondrial Dynamics and Health in the Alzheimer's Disease APP/PS1 Mouse Model Paliobeis, Andrew S. 12 May 2017 (has links) No description available. Biomedical Research Biology Biochemistry Alzheimers disease Mitochondrial dynamics Oxidative stress APP-PS1 mouse model
829	Biogeographic History of the Mulatta-Group Macaques as Inferred from Mitochondrial and Y-Chromosomal Molecular Markers Deja, Chelsea L. 12 May 2017 (has links) No description available. Animal Sciences Biology Physical Anthropology Macaques Biogoegoraphy Japan Taiwan Monkey Monkeys Genetic Y-chromosome Mitochondrial Mitochondria
830	Investigating Factors That Regulate the Direct Drp1-Mff Interaction Clinton, Ryan William 31 August 2018 (has links) No description available. Biochemistry Pharmacology

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