The thesis deals with using art therapy's methods and technique by multi-handicapped children. The first chapter characterizes multi-handicap, defines various disorders and their influence on the personality of a child. The second chapter introduces the therapy options which can be applied to multi-handicapped children, with a strong accent on artetherapy. In the third chapter there are various artetherapic methods and techniques which can be applied to multi-handicapped children. The fourth chapter shows creative expressions of children with the main accent on drawing, painting and modeling. The practical part describes civil associations where the research has been carried out, and presents the results of the research by means of five case studies. Keywords Multi-handicap, mental handicap, physical defect, cerebral defense, sensory defects, autism, art therapy, ergotherapeutics, music therapy, trampoline therapy, canistherapy, hippotherapy, snoezelen, artetherapic methods, drawing, painting, modeling