The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-closo-dodecaborane(12), as well as alpha-d-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-meta-carboranyl thiol.

Submitted by Emanuel Varela Cardoso (emanuel.varela@ufcg.edu.br) on 2018-05-10T18:00:56Z No. of bitstreams: 6 HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap 0.pdf: 390788 bytes, checksum: 6bd35ca677af3ae9e83b876ed6778f92 (MD5) HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap I.pdf: 186004 bytes, checksum: 6dfececbfff0aed10c1d3d770ea09604 (MD5) HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap II.pdf: 498769 bytes, checksum: 413e390cc4732c2c636c54e5685a89c0 (MD5) HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap III.pdf: 716490 bytes, checksum: 88a70a183ecdc6c3302ef0c2d34f57b4 (MD5) HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap IV.pdf: 2750520 bytes, checksum: 3f6b80a72dea065762045499726ffd7c (MD5) HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap V.pdf: 3212971 bytes, checksum: 4af10723b57412f888297c0c6f6bf73e (MD5) / Made available in DSpace on 2018-05-10T18:00:56Z (GMT). No. of bitstreams: 6 HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap 0.pdf: 390788 bytes, checksum: 6bd35ca677af3ae9e83b876ed6778f92 (MD5) HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap I.pdf: 186004 bytes, checksum: 6dfececbfff0aed10c1d3d770ea09604 (MD5) HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap II.pdf: 498769 bytes, checksum: 413e390cc4732c2c636c54e5685a89c0 (MD5) HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap III.pdf: 716490 bytes, checksum: 88a70a183ecdc6c3302ef0c2d34f57b4 (MD5) HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap IV.pdf: 2750520 bytes, checksum: 3f6b80a72dea065762045499726ffd7c (MD5) HELENALDO FIRMINO DE AZEVEDO – DISSERTAÇÃO (PPGDesign) 2016_Cap V.pdf: 3212971 bytes, checksum: 4af10723b57412f888297c0c6f6bf73e (MD5) Previous issue date: 2016-12-16 / O objetivo deste trabalho é analisar os impactos da modularização no desenvolvimento de produtos e no sistema produtivo de uma organização. O método utilizado foi o Modular Function Deployment (MFD) e a aplicação foi realizada em uma máquina de processamento de forragem animal. Os resultados alcançados com a modularização mostram que houve reduções de peças e de processos de fabricação com a modularização do produto. Diante desses resultados foi possível concluir que os impactos foram positivos tanto no desenvolvimento do produto como no sistema produtivo da organização em função da racionalização da produção, redução dos custos e possível aumento da produtividade. / This present work aims to analyze the impacts of modularization on product development and on the productive system of a particular organization. The chosen method was the Modular Function Deployment (MDF) and it was applied on a processing fodder machine. The results achieved with modularization shows reduction in the number of parts, likewise reduction in the number of manufacturing processes due to product’s modularization. Based on these results, it was possible to conclude that the impacts were positive both in product’s development stage and in the company production system due to production’s rationalization, costs reduction and a projected productivity increase.

This thesis focuses on concept of European Modular System. It describes its characteristics, main advantages and disadvantages and experiences of other countries. A separate chapter focuses on swap bodies so that modular heavy goods vehicles can be compared to them in practical part of this thesis. Aim of this thesis is to evaluate what is better for transport of particular goods, if classical semi-trailer unit with maximum allowed length of 16,5 m, combined transport road-rail with use of swap bodies or modular heavy goods vehicle. Costs, transpotation times and emissions will be compared in this section. The thesis also aims at evaluating if main arguments of opponents of this concept are eligible or not.

Der im Zuge der Globalisierung immer stärker anwachsende Wettbewerb im Bereich produzierender Unternehmen führt zu einem kontinuierlichen Wettlauf um stetig kürzer werdende Produktionslaufzeiten. Aufgrund dessen ist eine kontinuierliche Spezialisierung mit produktspezifischen Fertigungssystemen der Akteure am Markt zu verzeichnen, die direkt zu einer erhöhten Nachfrage von Sondermaschinen führt (Krause 2018). Diese geforderte Spezialisierung lässt eine interne Standardisierung für die Hersteller kaum zu und führt zu einer extrem hohen Variantenvielfalt, deren Beherrschung eine der Kernaufgaben bei der Sicherstellung der Wettbewerbsfähigkeit darstellt. Insbesondere große Produktstrukturen sind aufgrund der anfallenden Datenmenge und dem resultierenden, hohen Grad an Verknüpfungen schwierig zu verwalten (Blees 2011). Eine Möglichkeit, die interne Vielfalt bei einer gleichbleibenden externen Vielfalt zu reduzieren und somit den enormen Umfang der Produktarchitektur und deren Folgekosten einzuschränken, bietet die Modularisierung (Krause 2018). Die Entwicklung von modularen Produktstrukturen eröffnet mittels entsprechender Standardisierung die Möglichkeit, durch Modul-, Plattform-, und Baukastenentwicklung den Zielkonflikt zwischen Produktkosten und -vielfalt zu lösen (Ehrlenspiel 2009). Ein solcher Baukasten wird als notwendiges Mittel zur Beherrschung der Vielfalt betrachtet [...] Ein Ansatz zur Lösung dieser Problemstellung ist in der Literatur durch die Verwendung von PLM(Product-Lifecycle-Management)-Systemen beschrieben. Ein entsprechendes PLM-System soll die im Unternehmen existierende Daten- und Softwarestruktur verbinden und als Single-Source of Truth (Riesener 2017) fungieren, um die Konsistenz der Modelle zu gewährleisten. Allerdings wird gerade bei der Verwendung von Modellen bei der Schaffung und Verwaltung der Produktarchitektur deutlich, dass ein PLM-System hierzu nicht vollumfänglich dazu in der Lage ist, als einheitlicher Datenstamm zu fungieren. Hierbei ist die Ontologie, die Verwendung „einheitlicher Vokabeln“ (Kaufmann et al. 2014) zwischen den Systemen, um z. B. eine Konsistenzprüfung bei der Konfiguration zu implementieren, eine nicht zu unterschätzende Herausforderung bei der Umsetzung auf Basis eines reinen PLM-Systems. Wie in diesem Beitrag beschrieben wird, lässt sich diese Lücke mithilfe des MBSE (Model-Based Systems Engineering) schließen. [... aus der Einleitung]

The city with its urban density, infrastructure, and cultural, social and educational opportunities can be a desirable place to live for all - regardless of age, income or background. The city of today has changed considerably from the city of the 19th century. Neither is it the city of the future. However, it has great potential to anticipate to the challenges we will face in the future. It is a place that constantly changes. It is a living organism! This constant change is a challenge for architects to develop concepts and design-solutions that can react to shifting uses, zoning requirements, and dweller habits. The constant alteration of lifestyle, residential and commercial use, as well as job-related needs demands a high flexibity and adaptability in architecture and urban planning. Today's life is fast and unpredictable. Other contemporary issues such as sustainabilty or climate change are becoming key issues of today's discussion - in society, in the media and in world policy. Architects - responsible for our built environment - have to find innovative solutions to such ever-changing problems within their profession - within architecture. How can a concept, project or building be designed or constructed to anticipate those future needs, and what are the limits? To explore these questions and many more that followed I chose a site in midtown Washington DC. My thesis project includes 23 townhouses with partial retail, incorporated along an alley in the interior of a city block. The new development is integrated into the existing structure. / Master of Architecture

This master's thesis deals with design and implementation of modular system for two-way loudspeaker system's characteristics. Work focus mainly on the enclosure geometry and speaker placement. The individual modules of the system were designed and then implemented. Furthermore, the characteristics of these modules were measured and laboratory tasks using these modules were elaborated.

Diploma thesis Implementation of modular web based application deals with web modular systems. The aim of web modular system is to allow creating universal web presentation without necessity of creation new systems. Diploma thesis is devided into couple parts. Advantages of modular solution of web systems are highlighted in the first part and after that is analyzed the current situation of this problem. In the next part is designed own web modular system above all its kernel, modules and data model. In the final part is described own implementation of own designed system. The most stress is layed on security of the system. In the conclusion is summed up own solution and its most advantages.

This thesis deals with DCS for bulding control. The main aim was to develop a general system, which can be adapted according to the individual requirements and which should minimize costs too. Hardware modules, communication bus, communication protocol, system topology and regulation mechanisms, have been designed. Regulators have been set. There are introduced current realization and possible future extensions too. The high security and the high functionality topics are included.

In this work I aimed at designing a universal system for testing either STM32F407/417 by STMicroelectronics and later various sensors and communication buses. The result then is a main board with many specific connectors for individual buses even with connectors making all I/O pins accessible at the same time. Thanks to advanced switching regulators the power supply is capable of accepting a wide range of sources like single Li-Ion cell, pair of alkaline cells, 12V Lead battery, common wall power adapters (both DC and AC up to 15 Vpp ), USB, laboratory power supplies with multiple outputs and finally POE (Power Over Ethernet). Supply voltages are supervised by voltage comparators with an optical signalisation. (It is possible to determine the sick branch without a measuring instrument and blowing components in the most cases.) Another important parameter was a robustness of the supply and communication lines. There is a number of TVSs, chokes, and big and low ESR capacitors A PC software is intended for a basic functionality demonstration only.

This thesis contains a structural design of linear axis with a stroke up to 800mm and a maximum load of 800N. The thesis also deals with a modular assembly system of the linear axis based on the structural design. Linear axes can be fitted with rolled, whirled and grinded ball screws with thread pitch 5, 10, 16mm and rolled trapezoidal screws on pitch 4 and 8mm. The stroke of the linear axes can be selected in the range from 200 up to 800 mm, with a maximum load of 800N in all linear dimensions. The feed of linear axis is provided by shaped rolling guide way and four trucks. The modular system offers two servo motors with direct and indirect measuring four stepper engines with indirect measuring. The thesis also includes strength and functional calculations of principal components, graphs of the possible load on linear axis in different positions , durability of the ball screws, maximum speed and feed rate of the chosen screws, data sheet, 3D model, drawings and assembly drawings of the nodes.