Global ETD Search

41	Vliv fyzioterapie na rovnováhu u nemocných s roztroušenou sklerózou mozkomíšní / Physiotherapy impact on balance in multiple sclerosis Bartušová, Tatiana January 2013 (has links) Title: The effect of physiotherapy on balance in multiple sclerosis Objectives: The aim of this study is to compare efficacy between ambulatory individual physiotherapy and complex inpatient rehabilitation in people with multiple sclerosis on balance and subjective evaluation of general health. In ambulant program to compare effect of different physiotherapeutic methods (Motoric program activating therapy, Manual physiotherapy correction, Reflex Locomotion according to Vojta). Methods: A combined design of study. Ambulant program has randomised assessor blind design, in which subjects were divided into one of the three groups of ambulatory physiotherapy. A clinical study without control arm design is used in case of comparison between complex and ambulatory program. Results were analysed in 45 patients with multiple sclerosis (25 subjects of ambulatory program, 20 subjects of complex program). Subjects of the ambulatory program were divided into one of the three groups of ambulatory physiotherapy (Motoric program activating therapy, Manual physiotherapy correction, Reflex Locomotion according to Vojta), in which they absolved during two months 20 therapies (2-3 times per week, length 60 minutes). Subjects of complex program underwent complex inpatient rehabilitation with duration about 21 days. The...
42	Selective Retention of β-Carbolines and 7,12-Dimethylbenz[<i>a</i>]anthracene in the Brain : Role of Neuromelanin and Cytochrome P450 for Toxicity Östergren, Anna January 2005 (has links) <p>The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. </p><p>In this thesis it was demonstrated that norharman and harman had affinity to melanin and were retained in neuromelanin-containing neurons of frogs up to 30 days post-injection (the longest survival time examined). It was also demonstrated that norharman induced neurodegeneration, activation of glia cells and motor impairment in mice. Furthermore, this compound induced ER stress and cell death in PC12 cells. An in vitro model of dopamine melanin-loaded PC12 cells was developed in order to study the effect of melanin on norharman-induced toxicity. In this model, melanin seemed to attenuate toxicity induced by low concentrations of norharman. After exposure to the highest concentration of norharman, melanin clusters were disaggregated and there was an increased expression of stress proteins and caspases-3, known to be involved in apoptosis.</p><p>The polycyclic aromatic hydrocarbon, 7,12-dimethylbenz[<i>a</i>]anthracene was demonstrated to have a CYP1A1-dependent localization in endothelial cells in the choroid plexus, in the veins in the leptomeninges and in the cerebral veins of mice pre-treated with CYP1-inducers. </p><p>These results demonstrate that the distribution of environmental compounds could be influenced by the presence of neuromelanin and expression of CYP enzymes in the brain and that norharman may induce neurotoxic effects in vivo and in vitro.</p> Toxicology β-carboline neuromelanin norharman harman parkinsonism Parkinson's disease motoric impairment behaviour glia cells substantia nigra dopamine melanin PC12 cells ER stress grp78 hsp90 cytochrome P450 CYP1A1 CYP1B1 blood-brain interfaces 7,12-dimethylbenz[a]anthracene polycyclic aromatic hydrocarbon endothelial cell smooth muscle cell bioactivation Toxikologi Toxicology Toxikologi
43	Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain : Role of Neuromelanin and Cytochrome P450 for Toxicity Östergren, Anna January 2005 (has links) The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. In this thesis it was demonstrated that norharman and harman had affinity to melanin and were retained in neuromelanin-containing neurons of frogs up to 30 days post-injection (the longest survival time examined). It was also demonstrated that norharman induced neurodegeneration, activation of glia cells and motor impairment in mice. Furthermore, this compound induced ER stress and cell death in PC12 cells. An in vitro model of dopamine melanin-loaded PC12 cells was developed in order to study the effect of melanin on norharman-induced toxicity. In this model, melanin seemed to attenuate toxicity induced by low concentrations of norharman. After exposure to the highest concentration of norharman, melanin clusters were disaggregated and there was an increased expression of stress proteins and caspases-3, known to be involved in apoptosis. The polycyclic aromatic hydrocarbon, 7,12-dimethylbenz[a]anthracene was demonstrated to have a CYP1A1-dependent localization in endothelial cells in the choroid plexus, in the veins in the leptomeninges and in the cerebral veins of mice pre-treated with CYP1-inducers. These results demonstrate that the distribution of environmental compounds could be influenced by the presence of neuromelanin and expression of CYP enzymes in the brain and that norharman may induce neurotoxic effects in vivo and in vitro. Toxicology β-carboline neuromelanin norharman harman parkinsonism Parkinson's disease motoric impairment behaviour glia cells substantia nigra dopamine melanin PC12 cells ER stress grp78 hsp90 cytochrome P450 CYP1A1 CYP1B1 blood-brain interfaces 7,12-dimethylbenz[a]anthracene polycyclic aromatic hydrocarbon endothelial cell smooth muscle cell bioactivation Toxikologi Toxicology Toxikologi
44	Analýza změny zátěže asynchronního motoru z měření statorových proudů / Analysis of load variation of induction machine from measurement of stator currents Kroupa, Martin January 2015 (has links) This thesis is focused on the evaluation of rotor dynamics of the induction machine, which can be used as a basis for online diagnosis of driven load in the future. It describes the problem of time varying loading torque at its impact to electromagnetic variables in induction machine. Followed by the possible ways of monitoring and diagnostic of loading torque using Fourier analysis on supply current.

Page generated in 0.0342 seconds